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Article: Clinical correlations of transcriptional profile in patients infected with avian influenza H7N9 virus

TitleClinical correlations of transcriptional profile in patients infected with avian influenza H7N9 virus
Authors
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
The Journal Of Infectious Diseases, 2018, v. 218 n. 8, p. 1238-48 How to Cite?
AbstractBACKGROUND: Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. METHODS: We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. RESULTS: We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. CONCLUSIONS: We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.
Persistent Identifierhttp://hdl.handle.net/10722/263772
ISSN
2017 Impact Factor: 5.186
2015 SCImago Journal Rankings: 4.000
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorGuan, W-
dc.contributor.authorYang, Z-
dc.contributor.authorWu, NC-
dc.contributor.authorLee, HYH-
dc.contributor.authorLi, Y-
dc.contributor.authorJiang, W-
dc.contributor.authorShen, L-
dc.contributor.authorWu, DC-
dc.contributor.authorChen, R-
dc.contributor.authorZhong, N-
dc.contributor.authorWilson, IA-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorMok, KP-
dc.date.accessioned2018-10-22T07:44:14Z-
dc.date.available2018-10-22T07:44:14Z-
dc.date.issued2018-
dc.identifier.citationThe Journal Of Infectious Diseases, 2018, v. 218 n. 8, p. 1238-48-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/263772-
dc.description.abstractBACKGROUND: Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis. METHODS: We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis. RESULTS: We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found. CONCLUSIONS: We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org-
dc.relation.ispartofThe Journal Of Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleClinical correlations of transcriptional profile in patients infected with avian influenza H7N9 virus-
dc.typeArticle-
dc.identifier.emailLee, HYH: horlee@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailMok, KP: ch02mkp@hkucc.hku.hk-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityMok, KP=rp01805-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/infdis/jiy317-
dc.identifier.pmcidPMC6129114-
dc.identifier.hkuros293587-
dc.identifier.volume218-
dc.identifier.issue8-
dc.identifier.spage1238-
dc.identifier.epage48-
dc.publisher.placeUnited States-

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