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Conference Paper: Territory-wide study on the clinical characteristics and treatment uptake of patients with chronic hepatitis C in public hospitals in Hong Kong

TitleTerritory-wide study on the clinical characteristics and treatment uptake of patients with chronic hepatitis C in public hospitals in Hong Kong
Non-HKU
Authors
Issue Date2017
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Asian Pacific Digestive Week (APDW): The Future in Digestive Diseases, Hong Kong, 23–26 September 2017. In Journal of Gastroenterology and Hepatology, 2017, v. 32 n. S3, p. 158-159 How to Cite?
AbstractBackground: To study the clinical characteristics and treatment uptake of HCV infection in Hong Kong. Methods: From January 2005 to March 2017, patients who were tested positive for anti-HCV were retrospectively retrieved from all public hospitals. The epidemiological data of 15 participating hospitals were further analyzed. Results: A total of 12747 anti-HCV+ patients were identified. Among the 15 participating hospitals, there were 11309 anti-HCV+ cases, which accounted for 88.7% of the whole registry. Their median age was 59 years old (IQR 47 ––67, 47.2% ≥ 60 years), and 69% of them were male. Majority of them were Chinese (91.4%), followed by Pakistan (1.1%), Vietnamese (0.8%), Nepalese (0.5%), and Indian (0.4%). Genotypes were checked in 2397 patients, and the distribution were was genotype 1 (50.4%; 1b 95.7%, 1a 4.3%), genotype 6 (35.2%), genotype 3 (10.9%), and genotype 2 (3.4%). Other comorbidities included diabetes mellitus (23.6%), HBV co-infection (7.8%), severe renal impairment with eGFR< 30 ml/min/1.73 m 2 (7.1%), HIV co-infection (N = 158, 1.4%), hemophilia (N = 94, 0.8%), Cooley’s anemia and Hemoglobin H disease (N = 89, 0.8%). Organ transplantation were performed in 202 patients (kidney N = 118, 1.0%, liver N = 103, 0.9%, heart N = 1). The overall treatment uptake was 24.3% (N = 2201). Most of them had received PegInterferon / Ribavirin (N = 2061). The other antivirals used included Ombitasvir/ Paritaprevir/ Dasabuvir (N = 116), Boceprevir-based therapy (N = 54), Ledipasvir / Sofosbuvir (N = 37), Sofosbuvir-based therapy (N = 23), and Daclastavir/Asunaprevir (N = 7). Around 30.6% (N = 3456, annual all-cause mortality rate = 2.5%) of them were dead at the time of review, of which 26.0% were due to liver-related cause of death. The estimated number of untreated alive patients was 5224. Conclusion: Hepatitis C infection is not common in Hong Kong. However, more than a quarter of them will eventually die of liver-related complications. The treatment uptake remains suboptimal, and a more generalized use of direct-acting antivirals may help to improve the situation.
DescriptionE‐Poster Presentations – B1) Liver - no. P-0113
Persistent Identifierhttp://hdl.handle.net/10722/263578
ISSN
2017 Impact Factor: 3.483
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorHui, YT-
dc.contributor.authorWong, GLH-
dc.contributor.authorLiu, SD-
dc.contributor.authorLiu, SHK-
dc.contributor.authorMa, YK-
dc.contributor.authorBut, YKD-
dc.contributor.authorMak, WY-
dc.contributor.authorTsang, OTY-
dc.contributor.authorLai, KB-
dc.contributor.authorLoo, CK-
dc.contributor.authorNg, A-
dc.contributor.authorLai, MS-
dc.contributor.authorChan, CW-
dc.contributor.authorLau, JYL-
dc.contributor.authorFan, TTT-
dc.contributor.authorHui, AJ-
dc.contributor.authorLam, CY-
dc.contributor.authorCheung, WI-
dc.contributor.authorChan, J-
dc.contributor.authorLam, K-
dc.contributor.authorLai, LSW-
dc.contributor.authorLuk, WF-
dc.contributor.authorLi, KK-
dc.contributor.authorLao, WC-
dc.contributor.authorLam, JTW-
dc.contributor.authorTsang, S-
dc.contributor.authorKung, KN-
dc.contributor.authorChan, YK-
dc.contributor.authorChow, WH-
dc.contributor.authorLeung, CS-
dc.contributor.authorTo, CT-
dc.contributor.authorLi, CW-
dc.contributor.authorWong, J-
dc.contributor.authorTao, WL-
dc.contributor.authorChan, WS-
dc.contributor.authorChan, A-
dc.contributor.authorChan, R-
dc.contributor.authorLee, K-
dc.contributor.authorYau, W-
dc.contributor.authorHo, YH-
dc.contributor.authorKan, YM-
dc.contributor.authorLui, KL-
dc.contributor.authorShan, E-
dc.contributor.authorFung, JYY-
dc.contributor.authorChan, HLY-
dc.contributor.authorYuen, RMF-
dc.contributor.authorWong, VWS-
dc.date.accessioned2018-10-22T07:41:12Z-
dc.date.available2018-10-22T07:41:12Z-
dc.date.issued2017-
dc.identifier.citationAsian Pacific Digestive Week (APDW): The Future in Digestive Diseases, Hong Kong, 23–26 September 2017. In Journal of Gastroenterology and Hepatology, 2017, v. 32 n. S3, p. 158-159-
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/263578-
dc.descriptionE‐Poster Presentations – B1) Liver - no. P-0113-
dc.description.abstractBackground: To study the clinical characteristics and treatment uptake of HCV infection in Hong Kong. Methods: From January 2005 to March 2017, patients who were tested positive for anti-HCV were retrospectively retrieved from all public hospitals. The epidemiological data of 15 participating hospitals were further analyzed. Results: A total of 12747 anti-HCV+ patients were identified. Among the 15 participating hospitals, there were 11309 anti-HCV+ cases, which accounted for 88.7% of the whole registry. Their median age was 59 years old (IQR 47 ––67, 47.2% ≥ 60 years), and 69% of them were male. Majority of them were Chinese (91.4%), followed by Pakistan (1.1%), Vietnamese (0.8%), Nepalese (0.5%), and Indian (0.4%). Genotypes were checked in 2397 patients, and the distribution were was genotype 1 (50.4%; 1b 95.7%, 1a 4.3%), genotype 6 (35.2%), genotype 3 (10.9%), and genotype 2 (3.4%). Other comorbidities included diabetes mellitus (23.6%), HBV co-infection (7.8%), severe renal impairment with eGFR< 30 ml/min/1.73 m 2 (7.1%), HIV co-infection (N = 158, 1.4%), hemophilia (N = 94, 0.8%), Cooley’s anemia and Hemoglobin H disease (N = 89, 0.8%). Organ transplantation were performed in 202 patients (kidney N = 118, 1.0%, liver N = 103, 0.9%, heart N = 1). The overall treatment uptake was 24.3% (N = 2201). Most of them had received PegInterferon / Ribavirin (N = 2061). The other antivirals used included Ombitasvir/ Paritaprevir/ Dasabuvir (N = 116), Boceprevir-based therapy (N = 54), Ledipasvir / Sofosbuvir (N = 37), Sofosbuvir-based therapy (N = 23), and Daclastavir/Asunaprevir (N = 7). Around 30.6% (N = 3456, annual all-cause mortality rate = 2.5%) of them were dead at the time of review, of which 26.0% were due to liver-related cause of death. The estimated number of untreated alive patients was 5224. Conclusion: Hepatitis C infection is not common in Hong Kong. However, more than a quarter of them will eventually die of liver-related complications. The treatment uptake remains suboptimal, and a more generalized use of direct-acting antivirals may help to improve the situation.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH-
dc.relation.ispartofJournal of Gastroenterology and Hepatology-
dc.relation.ispartofAsian Pacific Digestive Week (APDW)-
dc.titleTerritory-wide study on the clinical characteristics and treatment uptake of patients with chronic hepatitis C in public hospitals in Hong Kong-
dc.titleNon-HKU-
dc.typeConference_Paper-
dc.identifier.emailLiu, SHK: drkliu@hku.hk-
dc.identifier.emailBut, YKD: drdbut@hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hku.hk-
dc.identifier.authorityYuen, RMF=rp00479-
dc.identifier.hkuros293858-
dc.identifier.volume32-
dc.identifier.issueS3-
dc.identifier.spage158-
dc.identifier.epage159-
dc.publisher.placeAustralia-

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