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Article: Predictive effect of hyperuricemia on left atrial stasis in non-valvular atrial fibrillation patients

TitlePredictive effect of hyperuricemia on left atrial stasis in non-valvular atrial fibrillation patients
Authors
KeywordsAtrial fibrillation
Hyperuricemia
Left atrial thrombus
Spontaneous echo contrast
Thromboembolic event
Issue Date2018
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal of Cardiology, 2018, v. 258, p. 103-108 How to Cite?
AbstractObjectives: To investigate the relationship between hyperuricemia and left atrial thrombus (LAT)/spontaneous echo contrast (SEC) and to determine the predictive value of hyperuricemia in non-valvular (NV) atrial fibrillation (AF) patients. Methods: The study retrospectively reviewed 1198 consecutive patients (male 801, female 397, and mean age of 56.84 ± 12.22) who were diagnosed with AF and accepted transesophageal echocardiography (TEE) prior to catheter ablation, appendage occlusion and electrical cardioversion using a single-center database. The clinical baseline characteristics were collected from medical record review and analyzed. Patients were categorized into an LAT/SEC group and a normal group. Results: According to the TEE examination, there were 97 (8.1%) patients with abnormality; of these, 49 were with LAT and 48 with SEC. The mean serum uric acid (SUA) level and hyperuricemia proportion were markedly higher in patients with LAT/SEC. The significant predictive effect was observed in the SUA level (OR = 1.006) and hyperuricemia (OR = 2.04). After adjustment for persistent/permanent-AF, age, gender, LA dimension > 40 mm, previous stroke, hypertension and diabetes, the SUA level (OR = 1.004) and hyperuricemia (OR = 1.69) were independent predictors for LAT/SEC. The SUA level (OR = 1.004) and hyperuricemia (OR = 1.69) were independent predictors for LAT/SEC, Further subgroup analysis in different CHA2DS2-VASc categories, it might be helpful to refine the LAT/SEC risk via combination area CHA2DS2-VASc score and hyperuricemia, especially in those with CHA2DS2-VASc score < 2. Conclusions: The SUA level and hyperuricemia proportion are closely associated with LA stasis. Hyperuricemia might independently predict and refine LA stasis risk among NVAF patients, especially in those with CHA2DS2-VASc score < 2.
Persistent Identifierhttp://hdl.handle.net/10722/263384
ISSN
2019 Impact Factor: 3.229
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, FZ-
dc.contributor.authorLiao, HT-
dc.contributor.authorLin, WD-
dc.contributor.authorXue, YM-
dc.contributor.authorZhan, XZ-
dc.contributor.authorFang, XH-
dc.contributor.authorRao, F-
dc.contributor.authorDeng, H-
dc.contributor.authorHuang, J-
dc.contributor.authorHai, SHJJ-
dc.contributor.authorTse, HF-
dc.contributor.authorWu, SL-
dc.date.accessioned2018-10-22T07:38:03Z-
dc.date.available2018-10-22T07:38:03Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Cardiology, 2018, v. 258, p. 103-108-
dc.identifier.issn0167-5273-
dc.identifier.urihttp://hdl.handle.net/10722/263384-
dc.description.abstractObjectives: To investigate the relationship between hyperuricemia and left atrial thrombus (LAT)/spontaneous echo contrast (SEC) and to determine the predictive value of hyperuricemia in non-valvular (NV) atrial fibrillation (AF) patients. Methods: The study retrospectively reviewed 1198 consecutive patients (male 801, female 397, and mean age of 56.84 ± 12.22) who were diagnosed with AF and accepted transesophageal echocardiography (TEE) prior to catheter ablation, appendage occlusion and electrical cardioversion using a single-center database. The clinical baseline characteristics were collected from medical record review and analyzed. Patients were categorized into an LAT/SEC group and a normal group. Results: According to the TEE examination, there were 97 (8.1%) patients with abnormality; of these, 49 were with LAT and 48 with SEC. The mean serum uric acid (SUA) level and hyperuricemia proportion were markedly higher in patients with LAT/SEC. The significant predictive effect was observed in the SUA level (OR = 1.006) and hyperuricemia (OR = 2.04). After adjustment for persistent/permanent-AF, age, gender, LA dimension > 40 mm, previous stroke, hypertension and diabetes, the SUA level (OR = 1.004) and hyperuricemia (OR = 1.69) were independent predictors for LAT/SEC. The SUA level (OR = 1.004) and hyperuricemia (OR = 1.69) were independent predictors for LAT/SEC, Further subgroup analysis in different CHA2DS2-VASc categories, it might be helpful to refine the LAT/SEC risk via combination area CHA2DS2-VASc score and hyperuricemia, especially in those with CHA2DS2-VASc score < 2. Conclusions: The SUA level and hyperuricemia proportion are closely associated with LA stasis. Hyperuricemia might independently predict and refine LA stasis risk among NVAF patients, especially in those with CHA2DS2-VASc score < 2.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard-
dc.relation.ispartofInternational Journal of Cardiology-
dc.subjectAtrial fibrillation-
dc.subjectHyperuricemia-
dc.subjectLeft atrial thrombus-
dc.subjectSpontaneous echo contrast-
dc.subjectThromboembolic event-
dc.titlePredictive effect of hyperuricemia on left atrial stasis in non-valvular atrial fibrillation patients-
dc.typeArticle-
dc.identifier.emailHai, SHJJ: haishjj@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityHai, SHJJ=rp02047-
dc.identifier.authorityTse, HF=rp00428-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijcard.2018.01.080-
dc.identifier.pmid29467096-
dc.identifier.scopuseid_2-s2.0-85042149366-
dc.identifier.hkuros294051-
dc.identifier.volume258-
dc.identifier.spage103-
dc.identifier.epage108-
dc.identifier.isiWOS:000427605700022-
dc.publisher.placeIreland-

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