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- Publisher Website: 10.1021/acschembio.8b00347
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Article: Sensing DNA through DNA Charge Transport
Title | Sensing DNA through DNA Charge Transport |
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Authors | |
Issue Date | 2018 |
Citation | ACS Chemical Biology, 2018, v. 13, n. 7, p. 1799-1809 How to Cite? |
Abstract | DNA charge transport chemistry involves the migration of charge over long molecular distances through the aromatic base pair stack within the DNA helix. This migration depends upon the intimate coupling of bases stacked one with another, and hence any perturbation in that stacking, through base modifications or protein binding, can be sensed electrically. In this review, we describe the many ways DNA charge transport chemistry has been utilized to sense changes in DNA, including the presence of lesions, mismatches, DNA-binding proteins, protein activity, and even reactions under weak magnetic fields. Charge transport chemistry is remarkable in its ability to sense the integrity of DNA. |
Persistent Identifier | http://hdl.handle.net/10722/262794 |
ISSN | 2021 Impact Factor: 4.634 2020 SCImago Journal Rankings: 1.899 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zwang, TJ | - |
dc.contributor.author | Tse, ECM | - |
dc.contributor.author | Barton, JK | - |
dc.date.accessioned | 2018-10-08T02:47:04Z | - |
dc.date.available | 2018-10-08T02:47:04Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | ACS Chemical Biology, 2018, v. 13, n. 7, p. 1799-1809 | - |
dc.identifier.issn | 1554-8929 | - |
dc.identifier.uri | http://hdl.handle.net/10722/262794 | - |
dc.description.abstract | DNA charge transport chemistry involves the migration of charge over long molecular distances through the aromatic base pair stack within the DNA helix. This migration depends upon the intimate coupling of bases stacked one with another, and hence any perturbation in that stacking, through base modifications or protein binding, can be sensed electrically. In this review, we describe the many ways DNA charge transport chemistry has been utilized to sense changes in DNA, including the presence of lesions, mismatches, DNA-binding proteins, protein activity, and even reactions under weak magnetic fields. Charge transport chemistry is remarkable in its ability to sense the integrity of DNA. | - |
dc.language | eng | - |
dc.relation.ispartof | ACS Chemical Biology | - |
dc.title | Sensing DNA through DNA Charge Transport | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acschembio.8b00347 | - |
dc.identifier.scopus | eid_2-s2.0-85047651855 | - |
dc.identifier.hkuros | 293828 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1799 | - |
dc.identifier.epage | 1809 | - |
dc.identifier.eissn | 1554-8937 | - |
dc.identifier.isi | WOS:000439761900010 | - |
dc.identifier.issnl | 1554-8929 | - |