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Article: Radix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-derived Nitrative Damage

TitleRadix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-derived Nitrative Damage
Authors
Keywords(NF-κB) signaling pathway
Macrophage
Multiple sclerosis
Nitrative damage
Radix Rehmanniae
Issue Date2018
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/physiology/
Citation
Frontiers in Physiology, 2018, v. 9 , article no. 864 How to Cite?
AbstractMultiple sclerosis (MS) is a neuroinflammatory disease in central nervous system (CNS) without effective treatment or medication yet. With high prevalence of MS patients worldwide and poor therapeutic outcome, seeking novel therapeutic strategy for MS is timely important. Radix Rehmanniae (RR), a typical Chinese Medicinal herb, has been used for neuroinflammatory diseases in Traditional Chinese Medicine for centuries. However, scientific evidence and underlying mechanisms of RR for MS are unclear. In this study, we tested the hypothesis that RR could attenuate the progress and severity of MS via suppressing macrophage-derived nitrative damage and inflammation by using experimental autoimmune encephalomyelitis (EAE) model for mimicking MS pathology. The results showed the RR treatment effectively ameliorated clinical disease severity, inhibited inflammation/demyelination in spinal cord, and alleviated CNS infiltration of encephalitogenic T cells and activated macrophages. Meanwhile, RR possessed bioactivities of scavenging ONOO- and reducing the expression of iNOS and NADPH oxidases in the spinal cords of the EAE mice. Furthermore, RR treatment suppressed nuclear factor-κB (NF-κB) signaling pathway in the splenocytes of EAE mice. The in vitro experiments on macrophages and neuronal cells exerted consistent results with the in vivo animal experiments. Taken together, we conclude that Radix Rehmanniae extract has therapeutic values for ameliorating EAE/MS pathological process and disease severity and its underlying mechanisms are associated with anti-inflammation and inhibiting macrophage-derived nitrative damages. Further study could yield novel promising therapeutic agent for multiple sclerosis.
Persistent Identifierhttp://hdl.handle.net/10722/262521
ISSN
2017 Impact Factor: 3.394
2015 SCImago Journal Rankings: 1.840
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, W-
dc.contributor.authorWu, H-
dc.contributor.authorGao, C-
dc.contributor.authorYang, D-
dc.contributor.authorYang, D-
dc.contributor.authorShen, J-
dc.date.accessioned2018-09-28T05:00:43Z-
dc.date.available2018-09-28T05:00:43Z-
dc.date.issued2018-
dc.identifier.citationFrontiers in Physiology, 2018, v. 9 , article no. 864-
dc.identifier.issn1664-042X-
dc.identifier.urihttp://hdl.handle.net/10722/262521-
dc.description.abstractMultiple sclerosis (MS) is a neuroinflammatory disease in central nervous system (CNS) without effective treatment or medication yet. With high prevalence of MS patients worldwide and poor therapeutic outcome, seeking novel therapeutic strategy for MS is timely important. Radix Rehmanniae (RR), a typical Chinese Medicinal herb, has been used for neuroinflammatory diseases in Traditional Chinese Medicine for centuries. However, scientific evidence and underlying mechanisms of RR for MS are unclear. In this study, we tested the hypothesis that RR could attenuate the progress and severity of MS via suppressing macrophage-derived nitrative damage and inflammation by using experimental autoimmune encephalomyelitis (EAE) model for mimicking MS pathology. The results showed the RR treatment effectively ameliorated clinical disease severity, inhibited inflammation/demyelination in spinal cord, and alleviated CNS infiltration of encephalitogenic T cells and activated macrophages. Meanwhile, RR possessed bioactivities of scavenging ONOO- and reducing the expression of iNOS and NADPH oxidases in the spinal cords of the EAE mice. Furthermore, RR treatment suppressed nuclear factor-κB (NF-κB) signaling pathway in the splenocytes of EAE mice. The in vitro experiments on macrophages and neuronal cells exerted consistent results with the in vivo animal experiments. Taken together, we conclude that Radix Rehmanniae extract has therapeutic values for ameliorating EAE/MS pathological process and disease severity and its underlying mechanisms are associated with anti-inflammation and inhibiting macrophage-derived nitrative damages. Further study could yield novel promising therapeutic agent for multiple sclerosis.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/physiology/-
dc.relation.ispartofFrontiers in Physiology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject(NF-κB) signaling pathway-
dc.subjectMacrophage-
dc.subjectMultiple sclerosis-
dc.subjectNitrative damage-
dc.subjectRadix Rehmanniae-
dc.titleRadix Rehmanniae Extract Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing Macrophage-derived Nitrative Damage-
dc.typeArticle-
dc.identifier.emailShen, J: shenjg@hku.hk-
dc.identifier.authorityShen, J=rp00487-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fphys.2018.00864-
dc.identifier.scopuseid_2-s2.0-85050248368-
dc.identifier.hkuros292991-
dc.identifier.volume9-
dc.identifier.spagearticle no. 864-
dc.identifier.epagearticle no. 864-
dc.identifier.isiWOS:000439406100001-
dc.publisher.placeSwitzerland-

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