File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cell polarity and cytoskeletons-Lesson from the testis

TitleCell polarity and cytoskeletons-Lesson from the testis
Authors
KeywordsActin
Actin nucleation
Blood-testis barrier
Cell polarity
Cytoskeleton
Issue Date2018
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcdb
Citation
Seminars in Cell and Developmental Biology, 2018, v. 81, p. 21-32 How to Cite?
AbstractCell polarity in the adult mammalian testis refers to the polarized alignment of developing spermatids during spermiogenesis and the polarized organization of organelles (e.g., phagosomes, endocytic vesicles, Sertoli cell nuclei, Golgi apparatus) in Sertoli cells and germ cells to support spermatogenesis. Without these distinctive features of cell polarity in the seminiferous epithelium, it is not possible to support the daily production of millions of sperm in the limited space provided by the seminiferous tubules in either rodent or human males through the adulthood. In short, cell polarity provides a novel mean to align spermatids and the supporting organelles (e.g., phagosomes, Golgi apparatus, endocytic vesicles) in a highly organized fashion spatially in the seminiferous epithelium during the epithelial cycle of spermatogenesis. This is analogous to different assembling units in a manufacturing plant such that as developing spermatids move along the 'assembly line' conferred by Sertoli cells, different structural/functional components can be added to (or removed from) the developing spermatids during spermiogenesis, so that functional spermatozoa are produced at the end of the assembly line. Herein, we briefly review findings regarding the regulation of cell polarity in the testis with specific emphasis on developing spermatids, supported by an intriguing network of regulatory proteins along a local functional axis. Emerging evidence has suggested that cell cytoskeletons provide the tracks which in turn confer the unique assembly lines in the seminiferous epithelium. We also provide some thought-provoking concepts based on which functional experiments can be designed in future studies.
Persistent Identifierhttp://hdl.handle.net/10722/262482
ISSN
2017 Impact Factor: 6.138
2015 SCImago Journal Rankings: 4.033
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWen, Q-
dc.contributor.authorMruk, DD-
dc.contributor.authorTang, EIY-
dc.contributor.authorWong, CKC-
dc.contributor.authorLui, WY-
dc.contributor.authorLee, WWM-
dc.contributor.authorXiao, X-
dc.contributor.authorSilvestrini, B-
dc.contributor.authorCheng, CY-
dc.date.accessioned2018-09-28T05:00:03Z-
dc.date.available2018-09-28T05:00:03Z-
dc.date.issued2018-
dc.identifier.citationSeminars in Cell and Developmental Biology, 2018, v. 81, p. 21-32-
dc.identifier.issn1084-9521-
dc.identifier.urihttp://hdl.handle.net/10722/262482-
dc.description.abstractCell polarity in the adult mammalian testis refers to the polarized alignment of developing spermatids during spermiogenesis and the polarized organization of organelles (e.g., phagosomes, endocytic vesicles, Sertoli cell nuclei, Golgi apparatus) in Sertoli cells and germ cells to support spermatogenesis. Without these distinctive features of cell polarity in the seminiferous epithelium, it is not possible to support the daily production of millions of sperm in the limited space provided by the seminiferous tubules in either rodent or human males through the adulthood. In short, cell polarity provides a novel mean to align spermatids and the supporting organelles (e.g., phagosomes, Golgi apparatus, endocytic vesicles) in a highly organized fashion spatially in the seminiferous epithelium during the epithelial cycle of spermatogenesis. This is analogous to different assembling units in a manufacturing plant such that as developing spermatids move along the 'assembly line' conferred by Sertoli cells, different structural/functional components can be added to (or removed from) the developing spermatids during spermiogenesis, so that functional spermatozoa are produced at the end of the assembly line. Herein, we briefly review findings regarding the regulation of cell polarity in the testis with specific emphasis on developing spermatids, supported by an intriguing network of regulatory proteins along a local functional axis. Emerging evidence has suggested that cell cytoskeletons provide the tracks which in turn confer the unique assembly lines in the seminiferous epithelium. We also provide some thought-provoking concepts based on which functional experiments can be designed in future studies.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcdb-
dc.relation.ispartofSeminars in Cell and Developmental Biology-
dc.subjectActin-
dc.subjectActin nucleation-
dc.subjectBlood-testis barrier-
dc.subjectCell polarity-
dc.subjectCytoskeleton-
dc.titleCell polarity and cytoskeletons-Lesson from the testis-
dc.typeArticle-
dc.identifier.emailWen, Q: wenqing8@HKUCC-COM.hku.hk-
dc.identifier.emailLui, WY: wylui@hku.hk-
dc.identifier.emailLee, WWM: hrszlwm@HKUCC-COM.hku.hk-
dc.identifier.authorityLui, WY=rp00756-
dc.identifier.authorityLee, WWM=rp00728-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.semcdb.2017.09.037-
dc.identifier.pmid28965865-
dc.identifier.pmcidPMC5889362-
dc.identifier.hkuros292311-
dc.identifier.volume81-
dc.identifier.spage21-
dc.identifier.epage32-
dc.identifier.isiWOS:000440657000004-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats