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Article: HLA-DQβ1 amino acid position 87 and DQB1*0301 are associated with Chinese Han SLE

TitleHLA-DQβ1 amino acid position 87 and DQB1*0301 are associated with Chinese Han SLE
Authors
Issue Date2018
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2324-9269
Citation
Molecular Genetics & Genomic Medicine, 2018, v. 6 n. 4, p. 541-546 How to Cite?
AbstractBACKGROUND: Several susceptibility loci have been identified associated with Chinese Han systemic lupus erythematosus (SLE). METHODS: We carried out imputation of classical HLA alleles, amino acids and Single Nucleotide Polymorphisms (SNPs) across the MHC region in Chinese Han SLE genome-wide association study (GWAS) of mainland and Hong Kong populations for the first time using newly constructed Han-MHC reference panel followed by stepwise conditional analysis. RESULTS: We mapped the most significant independent association to HLA-DQβ1 at amino acid position (Phe87, p = 7.807 × 10-17 ) and an independent association at HLA-DQB1*0301 (Pcondiational = 1.43 × 10-7 ). CONCLUSION: Our study illustrates the value of population-specific HLA reference panel for fine-mapping causal variants in the MHC.
Persistent Identifierhttp://hdl.handle.net/10722/262370
ISSN
2019 Impact Factor: 1.995
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSun, J-
dc.contributor.authorYang, C-
dc.contributor.authorFei, W-
dc.contributor.authorZhang, X-
dc.contributor.authorSheng, Y-
dc.contributor.authorZheng, X-
dc.contributor.authorTang, H-
dc.contributor.authorYang, W-
dc.contributor.authorYang, S-
dc.contributor.authorFan, X-
dc.contributor.authorZhang, X-
dc.date.accessioned2018-09-28T04:58:10Z-
dc.date.available2018-09-28T04:58:10Z-
dc.date.issued2018-
dc.identifier.citationMolecular Genetics & Genomic Medicine, 2018, v. 6 n. 4, p. 541-546-
dc.identifier.issn2324-9269-
dc.identifier.urihttp://hdl.handle.net/10722/262370-
dc.description.abstractBACKGROUND: Several susceptibility loci have been identified associated with Chinese Han systemic lupus erythematosus (SLE). METHODS: We carried out imputation of classical HLA alleles, amino acids and Single Nucleotide Polymorphisms (SNPs) across the MHC region in Chinese Han SLE genome-wide association study (GWAS) of mainland and Hong Kong populations for the first time using newly constructed Han-MHC reference panel followed by stepwise conditional analysis. RESULTS: We mapped the most significant independent association to HLA-DQβ1 at amino acid position (Phe87, p = 7.807 × 10-17 ) and an independent association at HLA-DQB1*0301 (Pcondiational = 1.43 × 10-7 ). CONCLUSION: Our study illustrates the value of population-specific HLA reference panel for fine-mapping causal variants in the MHC.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2324-9269-
dc.relation.ispartofMolecular Genetics & Genomic Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleHLA-DQβ1 amino acid position 87 and DQB1*0301 are associated with Chinese Han SLE-
dc.typeArticle-
dc.identifier.emailYang, W: yangwl@hku.hk-
dc.identifier.authorityYang, W=rp00524-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/mgg3.403-
dc.identifier.scopuseid_2-s2.0-85051114449-
dc.identifier.hkuros292101-
dc.identifier.volume6-
dc.identifier.issue4-
dc.identifier.spage541-
dc.identifier.epage546-
dc.identifier.isiWOS:000441004000008-
dc.publisher.placeUnited Kingdom-

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