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Article: Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment

TitlePelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment
Authors
Issue Date2018
PublisherElsevier: Creative Commons. The Journal's web site is located at http://www.ebiomedicine.com
Citation
EBioMedicine, 2018, v. 29, p. 159-165 How to Cite?
AbstractTubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is unclear. Successful intra-uterine embryo implantation is associated with increased expression of endometrial 'receptivity' integrins (cell adhesion molecules). We examined integrin expression in Fallopian tubes of women with previous C. trachomatis infection, in mice experimentally infected with C. trachomatis, in immortalised human oviductal epithelial cells (OE-E6/E7) and in an in vitro model of human embryo attachment (trophoblast spheroid-OE-E6/7 cell co-culture). Previous exposure with C. trachomatis increased Fallopian tube/oviduct integrin-subunit beta-1 (ITGB1) in women and mice compared to controls. C. trachomatis increased OE-E6/E7 cell ITGB1 expression and promoted trophoblast attachment to OE-E6/E7 cells which was negated by anti-ITGB1-antibody. We demonstrate that infection with C. trachomatis increases tubal ITGB1 expression, predisposing to tubal embryo attachment and ectopic pregnancy.
Persistent Identifierhttp://hdl.handle.net/10722/261919
ISSN
2017 Impact Factor: 6.183
2015 SCImago Journal Rankings: 1.304
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAhmad, SF-
dc.contributor.authorBrown, JK-
dc.contributor.authorCampbell, LL-
dc.contributor.authorKoscielniak, M-
dc.contributor.authorOliver, C-
dc.contributor.authorWheelhouse, N-
dc.contributor.authorEntrican, G-
dc.contributor.authorMcFee, S-
dc.contributor.authorWills, GS-
dc.contributor.authorMcClure, MO-
dc.contributor.authorHorner, PJ-
dc.contributor.authorGaikoumelou, S-
dc.contributor.authorLee, CKF-
dc.contributor.authorCritchley, HOD-
dc.contributor.authorDuncan, WC-
dc.contributor.authorHorne, AW-
dc.date.accessioned2018-09-28T04:50:20Z-
dc.date.available2018-09-28T04:50:20Z-
dc.date.issued2018-
dc.identifier.citationEBioMedicine, 2018, v. 29, p. 159-165-
dc.identifier.issn2352-3964-
dc.identifier.urihttp://hdl.handle.net/10722/261919-
dc.description.abstractTubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is unclear. Successful intra-uterine embryo implantation is associated with increased expression of endometrial 'receptivity' integrins (cell adhesion molecules). We examined integrin expression in Fallopian tubes of women with previous C. trachomatis infection, in mice experimentally infected with C. trachomatis, in immortalised human oviductal epithelial cells (OE-E6/E7) and in an in vitro model of human embryo attachment (trophoblast spheroid-OE-E6/7 cell co-culture). Previous exposure with C. trachomatis increased Fallopian tube/oviduct integrin-subunit beta-1 (ITGB1) in women and mice compared to controls. C. trachomatis increased OE-E6/E7 cell ITGB1 expression and promoted trophoblast attachment to OE-E6/E7 cells which was negated by anti-ITGB1-antibody. We demonstrate that infection with C. trachomatis increases tubal ITGB1 expression, predisposing to tubal embryo attachment and ectopic pregnancy.-
dc.languageeng-
dc.publisherElsevier: Creative Commons. The Journal's web site is located at http://www.ebiomedicine.com-
dc.relation.ispartofEBioMedicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment-
dc.typeArticle-
dc.identifier.emailLee, CKF: ckflee@hku.hk-
dc.identifier.authorityLee, CKF=rp00458-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.ebiom.2018.02.020-
dc.identifier.hkuros292319-
dc.identifier.volume29-
dc.identifier.spage159-
dc.identifier.epage165-
dc.identifier.isiWOS:000428131100020-
dc.publisher.placeNetherlands-

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