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Article: Imaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review

TitleImaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review
Authors
KeywordsWhite matter
Mild Cognitive Impairment
Cognitive reserve
Neuroplasticity
Cognition
Issue Date2017
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/10538135.php
Citation
NeuroRehabilitation, 2017, v. 41 n. 1, p. 189-204 How to Cite?
AbstractBACKGROUND: White matter lesions (WML) are prevalent in older adults. The association between WML and cognition in different subtypes of Mild Cognitive Impairment (MCI) is inconsistent in the literature. OBJECTVES: We aim to provide a systematic review on the impact of WML in different subtypes of MCI, and discuss the recent findings on white matter plasticity. METHODS: We reviewed peer-reviewed articles from January 2011 to August 2016 and identified 12 studies investigating the association between WML and subtypes of MCI with both neuroimaging and cognitive measures. RESULTS: Our review shows that 1) WM abnormality was identified between different subtypes of MCI and healthy controls on diffusion imaging; 2) neither visual ratings of WML nor its volumetry differentiate different subtypes of MCI or its prognosis to dementia; and 3) cognitive correlates of WML were evident in the Amnestic-type MCI in the domains of memory, language, psychomotor speed, attention and executive functions. CONCLUSION: Cognitive reserve and the plasticity of white matter may modulate the impact of WML on the manifestation of the neurodegenerative disease. Further research is needed to study the plasticity of white matter in the MCI population to evaluate its potential clinical application.
Persistent Identifierhttp://hdl.handle.net/10722/261691
ISSN
2020 Impact Factor: 2.138
2020 SCImago Journal Rankings: 0.611
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, CLM-
dc.contributor.authorYiend, J-
dc.contributor.authorLee, TMC-
dc.date.accessioned2018-09-28T04:46:07Z-
dc.date.available2018-09-28T04:46:07Z-
dc.date.issued2017-
dc.identifier.citationNeuroRehabilitation, 2017, v. 41 n. 1, p. 189-204-
dc.identifier.issn1053-8135-
dc.identifier.urihttp://hdl.handle.net/10722/261691-
dc.description.abstractBACKGROUND: White matter lesions (WML) are prevalent in older adults. The association between WML and cognition in different subtypes of Mild Cognitive Impairment (MCI) is inconsistent in the literature. OBJECTVES: We aim to provide a systematic review on the impact of WML in different subtypes of MCI, and discuss the recent findings on white matter plasticity. METHODS: We reviewed peer-reviewed articles from January 2011 to August 2016 and identified 12 studies investigating the association between WML and subtypes of MCI with both neuroimaging and cognitive measures. RESULTS: Our review shows that 1) WM abnormality was identified between different subtypes of MCI and healthy controls on diffusion imaging; 2) neither visual ratings of WML nor its volumetry differentiate different subtypes of MCI or its prognosis to dementia; and 3) cognitive correlates of WML were evident in the Amnestic-type MCI in the domains of memory, language, psychomotor speed, attention and executive functions. CONCLUSION: Cognitive reserve and the plasticity of white matter may modulate the impact of WML on the manifestation of the neurodegenerative disease. Further research is needed to study the plasticity of white matter in the MCI population to evaluate its potential clinical application.-
dc.languageeng-
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/10538135.php-
dc.relation.ispartofNeuroRehabilitation-
dc.subjectWhite matter-
dc.subjectMild Cognitive Impairment-
dc.subjectCognitive reserve-
dc.subjectNeuroplasticity-
dc.subjectCognition-
dc.titleImaging and neuropsychological correlates of white matter lesions in different subtypes of Mild Cognitive Impairment: A systematic review-
dc.typeArticle-
dc.identifier.emailLam, CLM: charlene.lam@hku.hk-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.authorityLam, CLM=rp02784-
dc.identifier.authorityLee, TMC=rp00564-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3233/NRE-171471-
dc.identifier.pmid28527230-
dc.identifier.scopuseid_2-s2.0-85025805726-
dc.identifier.hkuros292639-
dc.identifier.volume41-
dc.identifier.issue1-
dc.identifier.spage189-
dc.identifier.epage204-
dc.identifier.isiWOS:000406925200021-
dc.publisher.placeNetherlands-
dc.identifier.issnl1053-8135-

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