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Article: White matter microstructural abnormalities in amnestic mild cognitive impairment: A meta-analysis of whole-brain and ROI-based studies

TitleWhite matter microstructural abnormalities in amnestic mild cognitive impairment: A meta-analysis of whole-brain and ROI-based studies
Authors
KeywordsMild cognitive impairment
White matter
Meta-analysis
DTI
Aging
Activation likelihood estimation
Issue Date2017
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev
Citation
Neuroscience & Biobehavioral Reviews, 2017, v. 83, p. 405-416 How to Cite?
AbstractStudies that examined white matter (WM) alterations in amnestic mild cognitive impairment (aMCI) abound. This timely meta-analysis aims to synthesize the results of these studies. Seventy-seven studies (total NaMCI = 1844) were included. Fourteen region-of-interest-based (ROI-based) (k ≥ 8; NaMCI ≥ 284 per ROI) and two activation likelihood estimation (ALE) meta-analyses (fractional anisotropy [FA]: k = 15; NaMCI = 463; mean diffusivity [MD]: k = 8; NaMCI = 193) were carried out. Among the many significant ROI-related findings, reliable FA and MD alterations in the fornix, uncinate fasciculus, and parahippocampal cingulum were observed in aMCI. Larger effects were observed in MD relative to FA. The ALE meta-analysis revealed a significant FA decrease among aMCI subjects in the posterior corona radiata. These results provide robust evidence of the presence of WM abnormalities in aMCI. Our findings also highlight the importance of carrying out both ROI-based and whole-brain-based research to obtain a complete picture of WM microstructural alterations associated with the condition..
Persistent Identifierhttp://hdl.handle.net/10722/261318
ISSN
2020 Impact Factor: 8.989
2020 SCImago Journal Rankings: 3.590
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, J-
dc.contributor.authorLam, CLM-
dc.contributor.authorLee, TMC-
dc.date.accessioned2018-09-14T08:56:13Z-
dc.date.available2018-09-14T08:56:13Z-
dc.date.issued2017-
dc.identifier.citationNeuroscience & Biobehavioral Reviews, 2017, v. 83, p. 405-416-
dc.identifier.issn0149-7634-
dc.identifier.urihttp://hdl.handle.net/10722/261318-
dc.description.abstractStudies that examined white matter (WM) alterations in amnestic mild cognitive impairment (aMCI) abound. This timely meta-analysis aims to synthesize the results of these studies. Seventy-seven studies (total NaMCI = 1844) were included. Fourteen region-of-interest-based (ROI-based) (k ≥ 8; NaMCI ≥ 284 per ROI) and two activation likelihood estimation (ALE) meta-analyses (fractional anisotropy [FA]: k = 15; NaMCI = 463; mean diffusivity [MD]: k = 8; NaMCI = 193) were carried out. Among the many significant ROI-related findings, reliable FA and MD alterations in the fornix, uncinate fasciculus, and parahippocampal cingulum were observed in aMCI. Larger effects were observed in MD relative to FA. The ALE meta-analysis revealed a significant FA decrease among aMCI subjects in the posterior corona radiata. These results provide robust evidence of the presence of WM abnormalities in aMCI. Our findings also highlight the importance of carrying out both ROI-based and whole-brain-based research to obtain a complete picture of WM microstructural alterations associated with the condition..-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev-
dc.relation.ispartofNeuroscience & Biobehavioral Reviews-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectMild cognitive impairment-
dc.subjectWhite matter-
dc.subjectMeta-analysis-
dc.subjectDTI-
dc.subjectAging-
dc.subjectActivation likelihood estimation-
dc.titleWhite matter microstructural abnormalities in amnestic mild cognitive impairment: A meta-analysis of whole-brain and ROI-based studies-
dc.typeArticle-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.authorityLee, TMC=rp00564-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.neubiorev.2017.10.026-
dc.identifier.pmid29092777-
dc.identifier.scopuseid_2-s2.0-85032931625-
dc.identifier.hkuros290999-
dc.identifier.volume83-
dc.identifier.spage405-
dc.identifier.epage416-
dc.identifier.isiWOS:000419418700033-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0149-7634-

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