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Article: Combined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection

TitleCombined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection
Authors
KeywordsHeterosubtypic immunity
Influenza
Universal vaccine
Issue Date2018
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2018, v. 525, p. 73-82 How to Cite?
AbstractThe limited protection of current commerical vaccines necessitates the investigation of novel vaccine strategies for unpredictable outbreaks. To investigate the feasibility of using vaccines derived from Group 1 influenza A virus to induce broadly cross-reactive immune responses against multiple influenza subtypes, we tested a panel of sequential 4-dose immunization regimens in mice. Mice were treated with inactivated (seasonal H1N1, pandemic H1N1 and H5N1) and vaccinia virus-based H5N1 live-attenuated vaccines in different combinations. Mice were then challenged by viruses of either Group 1 (H1N1) or Group 2 (H3N2, H7N7) influenza virus. All studied sequential 4-dose vaccinations could induce some degrees of heterosubtypic protection in mice. Amongst all these regimens, the combined use of inactivated and live-attenuated vaccines could achieve the best heterologous protection. These results highlight the synergistic effect of combining different vaccine platforms to enhance heterosubtypic protection against influenza viruses.
Persistent Identifierhttp://hdl.handle.net/10722/261234
ISSN
2017 Impact Factor: 3.374
2015 SCImago Journal Rankings: 1.805
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYan, L-
dc.contributor.authorLi, OTW-
dc.contributor.authorPoh, CM-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorDoak, SA-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorPoon, LML-
dc.date.accessioned2018-09-14T08:54:46Z-
dc.date.available2018-09-14T08:54:46Z-
dc.date.issued2018-
dc.identifier.citationVirology, 2018, v. 525, p. 73-82-
dc.identifier.issn0042-6822-
dc.identifier.urihttp://hdl.handle.net/10722/261234-
dc.description.abstractThe limited protection of current commerical vaccines necessitates the investigation of novel vaccine strategies for unpredictable outbreaks. To investigate the feasibility of using vaccines derived from Group 1 influenza A virus to induce broadly cross-reactive immune responses against multiple influenza subtypes, we tested a panel of sequential 4-dose immunization regimens in mice. Mice were treated with inactivated (seasonal H1N1, pandemic H1N1 and H5N1) and vaccinia virus-based H5N1 live-attenuated vaccines in different combinations. Mice were then challenged by viruses of either Group 1 (H1N1) or Group 2 (H3N2, H7N7) influenza virus. All studied sequential 4-dose vaccinations could induce some degrees of heterosubtypic protection in mice. Amongst all these regimens, the combined use of inactivated and live-attenuated vaccines could achieve the best heterologous protection. These results highlight the synergistic effect of combining different vaccine platforms to enhance heterosubtypic protection against influenza viruses.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro-
dc.relation.ispartofVirology-
dc.subjectHeterosubtypic immunity-
dc.subjectInfluenza-
dc.subjectUniversal vaccine-
dc.titleCombined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection-
dc.typeArticle-
dc.identifier.emailYan, L: ylmeng@hku.hk-
dc.identifier.emailPoh, CM: pohcm@hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailDoak, SA: sophiev@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.authorityDoak, SA=rp02141-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityPoon, LML=rp00484-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.virol.2018.09.007-
dc.identifier.pmid30248524-
dc.identifier.scopuseid_2-s2.0-85053722283-
dc.identifier.hkuros291639-
dc.identifier.hkuros293645-
dc.identifier.volume525-
dc.identifier.spage73-
dc.identifier.epage82-
dc.identifier.isiWOS:000452938600008-
dc.publisher.placeUnited States-

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