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Conference Paper: RISKY DECISION-MAKING PERFORMANCE IN PATIENTS WITH EARLY SCHIZOPHRENIA-SPECTRUM DISORDER

TitleRISKY DECISION-MAKING PERFORMANCE IN PATIENTS WITH EARLY SCHIZOPHRENIA-SPECTRUM DISORDER
Authors
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
The Sixth Biennial Schizophrenia International Research Society (SIRS) Conference, Florence, Italy, 4-8 April 2018. Abstracts in Schizophrenia Bulletin, 2018, v. 44 n. s1, p. S243-S244 How to Cite?
AbstractBackground: Dysfunction in risky decision-making has been regarded as one potential contributing factor to functional impairment exhibited in patients with schizophrenia. Literature has revealed suboptimal risky decision-making in chronic schizophrenia patients. However, abnormality in risky decision-making has not been investigated in the early stage of illness. This study aimed to examine whether early schizophrenia patients displayed aberrant risky decision-making using two well-validated paradigms including Balloon Analogue Risk Task (BART; Lejuez et al., 2002) and Risky-Gains Task (RGT; Paulus et al., 2003). Methods: Thirty-three clinically-stable patients diagnosed with DSM-V schizophrenia-spectrum disorder (including schizophrenia, schizoaffective disorder or schizophreniform disorder) were recruited from specialized early intervention service for psychosis in Hong Kong. A group of healthy controls (n=32), matched with age, gender and educational levels, was enrolled for comparison. All participants were evaluated with a brief battery of cognitive assessment and two computerized risky decision-making tasks. Symptom assessment was also conducted for patients. Results: In both BART and RGT, patients with early schizophrenia-spectrum disorder performed worse than healthy controls regarding total points gained and reaction time. In BART, patients had significantly lower adjusted scores (F(1,63)=7.8, p<0.05) and lower balloon exploration rates than controls (F(1,63)=11.5, p<0.001), indicating that patients exhibited a tendency toward risk-aversion. In GRT, three-way analysis of variance revealed significant group x response interaction (F(1,63)=7.8, p<0.05), with post-hoc independent t-test showing that patients significantly preferred safe over risky options than controls (t=2.6, p<0.05). There were no significant correlations of risky decision-making parameters with symptom ratings and cognitive functions. Discussion: We extend previous findings of chronic samples to patients with early schizophrenia-spectrum disorder and indicate that suboptimal risky decision-making with risk-aversion preference has also been observed in the early course of illness. Further research is warranted to clarify the longitudinal change of aberrant risk-aversive behavioral patterns and its relationship with prospective functional and symptom outcomes.
DescriptionPoster Session II - no. F62
Persistent Identifierhttp://hdl.handle.net/10722/260805
ISSN
2017 Impact Factor: 6.944
2015 SCImago Journal Rankings: 4.051

 

DC FieldValueLanguage
dc.contributor.authorLuk, SK-
dc.contributor.authorLee, TMC-
dc.contributor.authorChen, EYH-
dc.contributor.authorChang, WC-
dc.date.accessioned2018-09-14T08:47:45Z-
dc.date.available2018-09-14T08:47:45Z-
dc.date.issued2018-
dc.identifier.citationThe Sixth Biennial Schizophrenia International Research Society (SIRS) Conference, Florence, Italy, 4-8 April 2018. Abstracts in Schizophrenia Bulletin, 2018, v. 44 n. s1, p. S243-S244-
dc.identifier.issn0586-7614-
dc.identifier.urihttp://hdl.handle.net/10722/260805-
dc.descriptionPoster Session II - no. F62-
dc.description.abstractBackground: Dysfunction in risky decision-making has been regarded as one potential contributing factor to functional impairment exhibited in patients with schizophrenia. Literature has revealed suboptimal risky decision-making in chronic schizophrenia patients. However, abnormality in risky decision-making has not been investigated in the early stage of illness. This study aimed to examine whether early schizophrenia patients displayed aberrant risky decision-making using two well-validated paradigms including Balloon Analogue Risk Task (BART; Lejuez et al., 2002) and Risky-Gains Task (RGT; Paulus et al., 2003). Methods: Thirty-three clinically-stable patients diagnosed with DSM-V schizophrenia-spectrum disorder (including schizophrenia, schizoaffective disorder or schizophreniform disorder) were recruited from specialized early intervention service for psychosis in Hong Kong. A group of healthy controls (n=32), matched with age, gender and educational levels, was enrolled for comparison. All participants were evaluated with a brief battery of cognitive assessment and two computerized risky decision-making tasks. Symptom assessment was also conducted for patients. Results: In both BART and RGT, patients with early schizophrenia-spectrum disorder performed worse than healthy controls regarding total points gained and reaction time. In BART, patients had significantly lower adjusted scores (F(1,63)=7.8, p<0.05) and lower balloon exploration rates than controls (F(1,63)=11.5, p<0.001), indicating that patients exhibited a tendency toward risk-aversion. In GRT, three-way analysis of variance revealed significant group x response interaction (F(1,63)=7.8, p<0.05), with post-hoc independent t-test showing that patients significantly preferred safe over risky options than controls (t=2.6, p<0.05). There were no significant correlations of risky decision-making parameters with symptom ratings and cognitive functions. Discussion: We extend previous findings of chronic samples to patients with early schizophrenia-spectrum disorder and indicate that suboptimal risky decision-making with risk-aversion preference has also been observed in the early course of illness. Further research is warranted to clarify the longitudinal change of aberrant risk-aversive behavioral patterns and its relationship with prospective functional and symptom outcomes.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/-
dc.relation.ispartofSchizophrenia Bulletin-
dc.relation.ispartof6th Schizophrenia International Research Society Conference-
dc.titleRISKY DECISION-MAKING PERFORMANCE IN PATIENTS WITH EARLY SCHIZOPHRENIA-SPECTRUM DISORDER-
dc.typeConference_Paper-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.authorityLee, TMC=rp00564-
dc.identifier.authorityChen, EYH=rp00392-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.doi10.1093/schbul/sby017.593-
dc.identifier.hkuros291394-
dc.identifier.volume44-
dc.identifier.issues1-
dc.identifier.spageS243-
dc.identifier.epageS244-
dc.publisher.placeUnited Kingdom-

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