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Conference Paper: A case‐control study on periodontitis and left ventricular function in patients with diabetes

TitleA case‐control study on periodontitis and left ventricular function in patients with diabetes
Authors
Issue Date2018
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X
Citation
EuroPerio 9, Amsterdam, The Netherlands, 20-23 June 2018. In Journal of Clinical Periodontology, 2018, v. 45 n. S19, p. 98 Abstract no. PD156 How to Cite?
AbstractBackground & Aim: Periodontal disease is closely linked to diabetes and cardiovascular disease, while the potential pathology and mechanisms involved in impaired cardiovascular function in patients with both periodontitis and diabetes remain unclear. This study aimed to investigate whether chronic periodontitis in patients with diabetes could be related to myocardial function and serological cardiac biomarkers. Methods: Seventy non‐smoking type 2 diabetic patients without cardiovascular complications were recruited, including 35 periodontitis subjects and 35 controls with matched age, gender and HbA1c levels. Following full‐mouth periodontal examination, echocardiography was performed to assess i) Left ventricle (LV) diastolic function by E/e’ defined as the ratio of trans‐mitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity; ii) LV systolic function by LV ejection fraction and speckle tracking derived global longitudinal strain (GLS); and iii) LV hypertrophy by LV mass index (LVMi). Cardiac stress‐related serological biomarkers were also measured, including Soluble ST2 (sST2) and N‐terminal fragment of brain natriuretic peptide (NT‐BNP). Results: Overall, the periodontitis patients exhibited higher levels of GLS and E/e’ ratio, along with increased concentrations of sST2 and NT‐BNP, with reference to those in the controls (p < 0.01). No significant difference in LVMi was found between the two groups. Univariate analysis showed that periodontitis and related variables including probing depth and clinical attachment loss were significantly associated with both GLS and E/e’ ratio (p < 0.05). Notably, the presence of periodontitis remained to be significantly correlated with GLS after adjusting for confounders (β = 1.30, 95% CI 0.37–2.24, p < 0.01). Conclusion: This case‐control study shows for the first time that periodontitis is independently associated with impaired myocardial systolic function in diabetes patients, which may increase the risk for developing adverse cardiovascular outcomes and other diabetic complications.
Persistent Identifierhttp://hdl.handle.net/10722/260683
ISSN
2017 Impact Factor: 4.046
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorWang, Y-
dc.contributor.authorZhen, Z-
dc.contributor.authorLiu, HN-
dc.contributor.authorLai, IA-
dc.contributor.authorPelekos, G-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.contributor.authorJin, L-
dc.date.accessioned2018-09-14T08:45:38Z-
dc.date.available2018-09-14T08:45:38Z-
dc.date.issued2018-
dc.identifier.citationEuroPerio 9, Amsterdam, The Netherlands, 20-23 June 2018. In Journal of Clinical Periodontology, 2018, v. 45 n. S19, p. 98 Abstract no. PD156-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/260683-
dc.description.abstractBackground & Aim: Periodontal disease is closely linked to diabetes and cardiovascular disease, while the potential pathology and mechanisms involved in impaired cardiovascular function in patients with both periodontitis and diabetes remain unclear. This study aimed to investigate whether chronic periodontitis in patients with diabetes could be related to myocardial function and serological cardiac biomarkers. Methods: Seventy non‐smoking type 2 diabetic patients without cardiovascular complications were recruited, including 35 periodontitis subjects and 35 controls with matched age, gender and HbA1c levels. Following full‐mouth periodontal examination, echocardiography was performed to assess i) Left ventricle (LV) diastolic function by E/e’ defined as the ratio of trans‐mitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity; ii) LV systolic function by LV ejection fraction and speckle tracking derived global longitudinal strain (GLS); and iii) LV hypertrophy by LV mass index (LVMi). Cardiac stress‐related serological biomarkers were also measured, including Soluble ST2 (sST2) and N‐terminal fragment of brain natriuretic peptide (NT‐BNP). Results: Overall, the periodontitis patients exhibited higher levels of GLS and E/e’ ratio, along with increased concentrations of sST2 and NT‐BNP, with reference to those in the controls (p < 0.01). No significant difference in LVMi was found between the two groups. Univariate analysis showed that periodontitis and related variables including probing depth and clinical attachment loss were significantly associated with both GLS and E/e’ ratio (p < 0.05). Notably, the presence of periodontitis remained to be significantly correlated with GLS after adjusting for confounders (β = 1.30, 95% CI 0.37–2.24, p < 0.01). Conclusion: This case‐control study shows for the first time that periodontitis is independently associated with impaired myocardial systolic function in diabetes patients, which may increase the risk for developing adverse cardiovascular outcomes and other diabetic complications.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.titleA case‐control study on periodontitis and left ventricular function in patients with diabetes-
dc.typeConference_Paper-
dc.identifier.emailLiu, HN: drdhnl@hku.hk-
dc.identifier.emailLai, IA: drianlai@hku.hk-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailJin, L: ljjin@hkucc.hku.hk-
dc.identifier.authorityPelekos, G=rp01894-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authorityJin, L=rp00028-
dc.identifier.doi10.1111/jcpe.160_12914-
dc.identifier.hkuros291782-
dc.identifier.volume45-
dc.identifier.issueS19-
dc.identifier.spage98 Abstract no. PD156-
dc.identifier.epage98 Abstract no. PD156-
dc.publisher.placeUnited States-

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