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- Publisher Website: 10.1021/jacs.6b02435
- Scopus: eid_2-s2.0-84971343041
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Article: Extended Release of Native Drug Conjugated in Polyketal Microparticles
Title | Extended Release of Native Drug Conjugated in Polyketal Microparticles |
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Authors | |
Issue Date | 2016 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html |
Citation | Journal of the American Chemical Society, 2016, v. 138 n. 19, p. 6127-6130 How to Cite? |
Abstract | Polyketals, which can be biodegradable, have good biocompatibility, and are pH-sensitive, could have broad applicability in drug delivery and other biomedical applications. However, facile synthesis of high molecular weight polyketals is challenging, and short durations of drug release from polyketal particulate formulations limit their application in drug delivery. Here we report the synthesis of a di-isopropenyl ether monomer and its use to synthesize high molecular weight estradiol-polyketal conjugates by addition polymerization. Microparticles were prepared from the estradiol-polyketal conjugate, where estradiol was incorporated into the polymer backbone. The particles had high drug loading and significantly prolonged drug release. Release of estradiol from the drug-polyketal conjugate microparticles was acid-responsive, as evidenced by faster drug release at low pH and with co-incorporation of PLGA. Tissue reaction to the microparticles was benign in vivo. Polyketal drug conjugates are promising candidates for long-acting drug delivery systems to treat chronic diseases. |
Persistent Identifier | http://hdl.handle.net/10722/260277 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Guo, ST | - |
dc.contributor.author | Nakagawa, Y | - |
dc.contributor.author | Barhoumi, A | - |
dc.contributor.author | Wang, W | - |
dc.contributor.author | Zhan, CY | - |
dc.contributor.author | Tong, R | - |
dc.contributor.author | Santamaria, C | - |
dc.contributor.author | Kohane, DS | - |
dc.date.accessioned | 2018-09-12T07:02:51Z | - |
dc.date.available | 2018-09-12T07:02:51Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2016, v. 138 n. 19, p. 6127-6130 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/260277 | - |
dc.description.abstract | Polyketals, which can be biodegradable, have good biocompatibility, and are pH-sensitive, could have broad applicability in drug delivery and other biomedical applications. However, facile synthesis of high molecular weight polyketals is challenging, and short durations of drug release from polyketal particulate formulations limit their application in drug delivery. Here we report the synthesis of a di-isopropenyl ether monomer and its use to synthesize high molecular weight estradiol-polyketal conjugates by addition polymerization. Microparticles were prepared from the estradiol-polyketal conjugate, where estradiol was incorporated into the polymer backbone. The particles had high drug loading and significantly prolonged drug release. Release of estradiol from the drug-polyketal conjugate microparticles was acid-responsive, as evidenced by faster drug release at low pH and with co-incorporation of PLGA. Tissue reaction to the microparticles was benign in vivo. Polyketal drug conjugates are promising candidates for long-acting drug delivery systems to treat chronic diseases. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.title | Extended Release of Native Drug Conjugated in Polyketal Microparticles | - |
dc.type | Article | - |
dc.identifier.email | Wang, W: wangwp@hku.hk | - |
dc.identifier.authority | Wang, W=rp02227 | - |
dc.identifier.doi | 10.1021/jacs.6b02435 | - |
dc.identifier.scopus | eid_2-s2.0-84971343041 | - |
dc.identifier.hkuros | 700003529 | - |
dc.identifier.volume | 138 | - |
dc.identifier.issue | 19 | - |
dc.identifier.spage | 6127 | - |
dc.identifier.epage | 6130 | - |
dc.identifier.isi | WOS:000376331000010 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0002-7863 | - |