File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1080/15592294.2016.1270486
- Scopus: eid_2-s2.0-85010693168
- PMID: 28075199
- WOS: WOS:000395177800001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: An epigenome-wide association analysis of cardiac autonomic responses among a population of welders
Title | An epigenome-wide association analysis of cardiac autonomic responses among a population of welders |
---|---|
Authors | |
Keywords | GPR133 EWAS heart rate epigenetics deceleration Acceleration |
Issue Date | 2017 |
Citation | Epigenetics, 2017, v. 12, n. 2, p. 71-76 How to Cite? |
Abstract | © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC © 2017, © Jinming Zhang, Zhonghua Liu, Peter E. Umukoro, Jennifer M. Cavallari, Shona C. Fang, Marc G. Weisskopf, Xihong Lin, Murray A. Mittleman, and David C. Christiani. DNA methylation is one of the potential epigenetic mechanisms associated with various adverse cardiovascular effects; however, its association with cardiac autonomic dysfunction, in particular, is unknown. In the current study, we aimed to identify epigenetic variants associated with alterations in cardiac autonomic responses. Cardiac autonomic responses were measured with two novel markers: acceleration capacity (AC) and deceleration capacity (DC). We examined DNA methylation levels at more than 472,506 CpG probes through the Illumina Infinium HumanMethylation450 BeadChip assay. We conducted separate linear mixed models to examine associations of DNA methylation levels at each CpG with AC and DC. One CpG (cg26829071) located in the GPR133 gene was negatively associated with DC values after multiple testing corrections through false discovery rate. Our study suggests the potential functional importance of methylation in cardiac autonomic responses. Findings from the current study need to be replicated in future studies in a larger population. |
Persistent Identifier | http://hdl.handle.net/10722/260230 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 1.149 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Jinming | - |
dc.contributor.author | Liu, Zhonghua | - |
dc.contributor.author | Umukoro, Peter E. | - |
dc.contributor.author | Cavallari, Jennifer M. | - |
dc.contributor.author | Fang, Shona C. | - |
dc.contributor.author | Weisskopf, Marc G. | - |
dc.contributor.author | Lin, Xihong | - |
dc.contributor.author | Mittleman, Murray A. | - |
dc.contributor.author | Christiani, David C. | - |
dc.date.accessioned | 2018-09-12T02:00:51Z | - |
dc.date.available | 2018-09-12T02:00:51Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Epigenetics, 2017, v. 12, n. 2, p. 71-76 | - |
dc.identifier.issn | 1559-2294 | - |
dc.identifier.uri | http://hdl.handle.net/10722/260230 | - |
dc.description.abstract | © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC © 2017, © Jinming Zhang, Zhonghua Liu, Peter E. Umukoro, Jennifer M. Cavallari, Shona C. Fang, Marc G. Weisskopf, Xihong Lin, Murray A. Mittleman, and David C. Christiani. DNA methylation is one of the potential epigenetic mechanisms associated with various adverse cardiovascular effects; however, its association with cardiac autonomic dysfunction, in particular, is unknown. In the current study, we aimed to identify epigenetic variants associated with alterations in cardiac autonomic responses. Cardiac autonomic responses were measured with two novel markers: acceleration capacity (AC) and deceleration capacity (DC). We examined DNA methylation levels at more than 472,506 CpG probes through the Illumina Infinium HumanMethylation450 BeadChip assay. We conducted separate linear mixed models to examine associations of DNA methylation levels at each CpG with AC and DC. One CpG (cg26829071) located in the GPR133 gene was negatively associated with DC values after multiple testing corrections through false discovery rate. Our study suggests the potential functional importance of methylation in cardiac autonomic responses. Findings from the current study need to be replicated in future studies in a larger population. | - |
dc.language | eng | - |
dc.relation.ispartof | Epigenetics | - |
dc.subject | GPR133 | - |
dc.subject | EWAS | - |
dc.subject | heart rate | - |
dc.subject | epigenetics | - |
dc.subject | deceleration | - |
dc.subject | Acceleration | - |
dc.title | An epigenome-wide association analysis of cardiac autonomic responses among a population of welders | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1080/15592294.2016.1270486 | - |
dc.identifier.pmid | 28075199 | - |
dc.identifier.scopus | eid_2-s2.0-85010693168 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 71 | - |
dc.identifier.epage | 76 | - |
dc.identifier.eissn | 1559-2308 | - |
dc.identifier.isi | WOS:000395177800001 | - |
dc.identifier.issnl | 1559-2294 | - |