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- Publisher Website: 10.7554/eLife.28231
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Article: E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae
Title | E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae |
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Authors | |
Issue Date | 2017 |
Publisher | eLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/ |
Citation | eLife, 2017, v. 6, p. e28231:1-e28231:27 How to Cite? |
Abstract | Bre1, a conserved E3 ubiquitin ligase in Saccharomyces cerevisiae, together with its interacting partner Lge1, are responsible for histone H2B monoubiquitination, which regulates transcription, DNA replication, and DNA damage response and repair, ensuring the structural integrity of the genome. Deletion of BRE1 or LGE1 also results in whole chromosome instability. We discovered a novel role for Bre1, Lge1 and H2Bub1 in chromosome segregation and sister chromatid cohesion. Bre1’s function in G1 and S phases contributes to cohesion establishment, but it is not required for cohesion maintenance in G2 phase. Bre1 is dispensable for the loading of cohesin complex to chromatin in G1, but regulates the localization of replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins in G1 and S phases, and promotes cohesin subunit Smc3 acetylation for cohesion stabilization. H2Bub1 epigenetically marks the origins, potentially signaling the coupling of DNA replication and cohesion establishment. |
Persistent Identifier | http://hdl.handle.net/10722/259930 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 3.932 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | ZHANG, W | - |
dc.contributor.author | Yeung, CHL | - |
dc.contributor.author | Wu, L | - |
dc.contributor.author | Yuen, KWY | - |
dc.date.accessioned | 2018-09-03T04:17:40Z | - |
dc.date.available | 2018-09-03T04:17:40Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | eLife, 2017, v. 6, p. e28231:1-e28231:27 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/10722/259930 | - |
dc.description.abstract | Bre1, a conserved E3 ubiquitin ligase in Saccharomyces cerevisiae, together with its interacting partner Lge1, are responsible for histone H2B monoubiquitination, which regulates transcription, DNA replication, and DNA damage response and repair, ensuring the structural integrity of the genome. Deletion of BRE1 or LGE1 also results in whole chromosome instability. We discovered a novel role for Bre1, Lge1 and H2Bub1 in chromosome segregation and sister chromatid cohesion. Bre1’s function in G1 and S phases contributes to cohesion establishment, but it is not required for cohesion maintenance in G2 phase. Bre1 is dispensable for the loading of cohesin complex to chromatin in G1, but regulates the localization of replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins in G1 and S phases, and promotes cohesin subunit Smc3 acetylation for cohesion stabilization. H2Bub1 epigenetically marks the origins, potentially signaling the coupling of DNA replication and cohesion establishment. | - |
dc.language | eng | - |
dc.publisher | eLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/ | - |
dc.relation.ispartof | eLife | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae | - |
dc.type | Article | - |
dc.identifier.email | Yuen, KWY: kwyyuen@hku.hk | - |
dc.identifier.authority | Yuen, KWY=rp01512 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.7554/eLife.28231 | - |
dc.identifier.scopus | eid_2-s2.0-85036552896 | - |
dc.identifier.hkuros | 288328 | - |
dc.identifier.hkuros | 302865 | - |
dc.identifier.hkuros | 301157 | - |
dc.identifier.volume | 6 | - |
dc.identifier.spage | e28231:1 | - |
dc.identifier.epage | e28231:27 | - |
dc.identifier.isi | WOS:000424299100001 | - |
dc.publisher.place | Cambridge, UK | - |
dc.identifier.issnl | 2050-084X | - |