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- Publisher Website: 10.1038/s41467-018-04792-7
- Scopus: eid_2-s2.0-85048727537
- PMID: 29907765
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Article: Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
Title | Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza |
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Authors | |
Issue Date | 2018 |
Publisher | Nature Publishing Group: Nature Communications. The Journal's web site is located at http://www.nature.com/ncomms/index.html |
Citation | Nature Communications, 2018, v. 9, article no. 2358 How to Cite? |
Abstract | Limited efficacy of current antivirals and antiviral-resistant mutations impairs anti-influenza treatment. Here, we evaluate the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Viral replication is significantly reduced in cell lines transfected with DIG-3. Mice treated with DIG-3 encoded by jetPEI-vector, as prophylaxis and therapeutics against A(H7N7) virus, respectively, have significantly better survivals (80% and 50%) than control mice (0%). We further develop a dual-functional peptide TAT-P1, which delivers DIG-3 with high efficiency and concomitantly exerts antiviral activity by preventing endosomal acidification. TAT-P1/DIG-3 is more effective than jetPEI/DIG-3 in treating A(H7N7) or A(H1N1)pdm09-infected mice and shows potent prophylactic protection on A(H7N7) or A(H1N1)pdm09-infected mice. The addition of P1 peptide, which prevents endosomal acidification, can enhance the protection of TAT-P1/DIG-3 on A(H1N1)pdm09-infected mice. Dual-functional TAT-P1 with DIG-3 can effectively protect or treat mice infected by avian and seasonal influenza virus. |
Persistent Identifier | http://hdl.handle.net/10722/259407 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 4.887 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhao, H | - |
dc.contributor.author | To, KKW | - |
dc.contributor.author | Chu, H | - |
dc.contributor.author | Ding, Q | - |
dc.contributor.author | Zhao, X | - |
dc.contributor.author | Li, C | - |
dc.contributor.author | Shuai, H | - |
dc.contributor.author | Yuan, S | - |
dc.contributor.author | Zhou, J | - |
dc.contributor.author | Kok, KH | - |
dc.contributor.author | Jiang, S | - |
dc.contributor.author | Yuen, KY | - |
dc.date.accessioned | 2018-09-03T04:06:57Z | - |
dc.date.available | 2018-09-03T04:06:57Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Nature Communications, 2018, v. 9, article no. 2358 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10722/259407 | - |
dc.description.abstract | Limited efficacy of current antivirals and antiviral-resistant mutations impairs anti-influenza treatment. Here, we evaluate the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Viral replication is significantly reduced in cell lines transfected with DIG-3. Mice treated with DIG-3 encoded by jetPEI-vector, as prophylaxis and therapeutics against A(H7N7) virus, respectively, have significantly better survivals (80% and 50%) than control mice (0%). We further develop a dual-functional peptide TAT-P1, which delivers DIG-3 with high efficiency and concomitantly exerts antiviral activity by preventing endosomal acidification. TAT-P1/DIG-3 is more effective than jetPEI/DIG-3 in treating A(H7N7) or A(H1N1)pdm09-infected mice and shows potent prophylactic protection on A(H7N7) or A(H1N1)pdm09-infected mice. The addition of P1 peptide, which prevents endosomal acidification, can enhance the protection of TAT-P1/DIG-3 on A(H1N1)pdm09-infected mice. Dual-functional TAT-P1 with DIG-3 can effectively protect or treat mice infected by avian and seasonal influenza virus. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group: Nature Communications. The Journal's web site is located at http://www.nature.com/ncomms/index.html | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza | - |
dc.type | Article | - |
dc.identifier.email | Zhao, H: hjzhao13@hku.hk | - |
dc.identifier.email | To, KKW: kelvinto@hku.hk | - |
dc.identifier.email | Chu, H: hinchu@hku.hk | - |
dc.identifier.email | Li, C: licun@hku.hk | - |
dc.identifier.email | Shuai, HV: shuaihp@hku.hk | - |
dc.identifier.email | Yuan, S: yuansf@hku.hk | - |
dc.identifier.email | Zhou, J: jiezhou@hku.hk | - |
dc.identifier.email | Kok, KH: khkok@hku.hk | - |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | - |
dc.identifier.authority | To, KKW=rp01384 | - |
dc.identifier.authority | Chu, H=rp02125 | - |
dc.identifier.authority | Zhou, J=rp01412 | - |
dc.identifier.authority | Kok, KH=rp01455 | - |
dc.identifier.authority | Yuen, KY=rp00366 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-018-04792-7 | - |
dc.identifier.pmid | 29907765 | - |
dc.identifier.pmcid | PMC6004018 | - |
dc.identifier.scopus | eid_2-s2.0-85048727537 | - |
dc.identifier.hkuros | 288903 | - |
dc.identifier.volume | 9 | - |
dc.identifier.spage | article no. 2358 | - |
dc.identifier.epage | article no. 2358 | - |
dc.identifier.isi | WOS:000435438300002 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2041-1723 | - |