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Article: Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension
Title | Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension |
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Authors | |
Keywords | arterial stiffness cardiac function non-dipper hypertension speckle tracking strain |
Issue Date | 2018 |
Publisher | BC Decker Inc. The Journal's web site is located at http://www.bcdecker.com/productDetails.aspx?BJID=87 |
Citation | Journal of Investigative Medicine, 2018, v. 66 n. 2, p. 319-324 How to Cite? |
Abstract | A non-dipper pattern of high blood pressure is associated with increased risk of organ damage and cardiovascular disease in patients with hypertension. The aim of the study was to evaluate the left ventricular (LV) remodeling and function and arterial stiffness in a dipper/non-dipper pattern of high blood pressure in patients with hypertension. A total of 183 hypertensive patients with no history of adverse cardiovascular events were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 66 patients with a dipper pattern and 117 patients with non-dipper pattern. Detailed transthoracic echocardiogram was performed and analyzed with advance speckle tracking 3-orthogonal direction strain analysis to assess LV systolic function and tissue Doppler-derived E/E' for LV diastolic function assessment. Cardio ankle vascular index (CAVI) was used to evaluate arterial stiffness. Compared with patients with dipper hypertension, those with non-dipper hypertension had increased LV mass index, higher prevalence of eccentric and concentric LV hypertrophy, more impaired LV diastolic and systolic function and peripheral arterial stiffness. Multivariable analysis revealed that a non-dipper pattern was independently associated with LV systolic dysfunction evaluated by speckle tracking-derived strain analysis. In conclusion, a non-dipper pattern of hypertension is an independent risk factor for LV systolic dysfunction. Treatment that could reverse this non-dipper pattern may reduce cardiac damage in these patients. |
Persistent Identifier | http://hdl.handle.net/10722/259393 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.696 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, Y | - |
dc.contributor.author | Liu, JH | - |
dc.contributor.author | Zhen, Z | - |
dc.contributor.author | Zuo, Y | - |
dc.contributor.author | Yiu, KH | - |
dc.contributor.author | Lin, Q | - |
dc.contributor.author | Liu, M | - |
dc.contributor.author | Zhao, C | - |
dc.contributor.author | Wu, M | - |
dc.contributor.author | Cao, G | - |
dc.contributor.author | Wang, R | - |
dc.contributor.author | Tse, HF | - |
dc.contributor.author | Yiu, KH | - |
dc.date.accessioned | 2018-09-03T04:06:42Z | - |
dc.date.available | 2018-09-03T04:06:42Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Journal of Investigative Medicine, 2018, v. 66 n. 2, p. 319-324 | - |
dc.identifier.issn | 1081-5589 | - |
dc.identifier.uri | http://hdl.handle.net/10722/259393 | - |
dc.description.abstract | A non-dipper pattern of high blood pressure is associated with increased risk of organ damage and cardiovascular disease in patients with hypertension. The aim of the study was to evaluate the left ventricular (LV) remodeling and function and arterial stiffness in a dipper/non-dipper pattern of high blood pressure in patients with hypertension. A total of 183 hypertensive patients with no history of adverse cardiovascular events were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 66 patients with a dipper pattern and 117 patients with non-dipper pattern. Detailed transthoracic echocardiogram was performed and analyzed with advance speckle tracking 3-orthogonal direction strain analysis to assess LV systolic function and tissue Doppler-derived E/E' for LV diastolic function assessment. Cardio ankle vascular index (CAVI) was used to evaluate arterial stiffness. Compared with patients with dipper hypertension, those with non-dipper hypertension had increased LV mass index, higher prevalence of eccentric and concentric LV hypertrophy, more impaired LV diastolic and systolic function and peripheral arterial stiffness. Multivariable analysis revealed that a non-dipper pattern was independently associated with LV systolic dysfunction evaluated by speckle tracking-derived strain analysis. In conclusion, a non-dipper pattern of hypertension is an independent risk factor for LV systolic dysfunction. Treatment that could reverse this non-dipper pattern may reduce cardiac damage in these patients. | - |
dc.language | eng | - |
dc.publisher | BC Decker Inc. The Journal's web site is located at http://www.bcdecker.com/productDetails.aspx?BJID=87 | - |
dc.relation.ispartof | Journal of Investigative Medicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | arterial stiffness | - |
dc.subject | cardiac function | - |
dc.subject | non-dipper hypertension | - |
dc.subject | speckle tracking strain | - |
dc.title | Assessment of left ventricular function and peripheral vascular arterial stiffness in patients with dipper and non-dipper hypertension | - |
dc.type | Article | - |
dc.identifier.email | Chen, Y: cheny818@hku.hk | - |
dc.identifier.email | Zhen, Z: zhenzhe@hku.hk | - |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | - |
dc.identifier.authority | Yiu, KH=rp01490 | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.identifier.authority | Yiu, KH=rp01490 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1136/jim-2017-000513 | - |
dc.identifier.pmid | 28935634 | - |
dc.identifier.pmcid | PMC5800354 | - |
dc.identifier.scopus | eid_2-s2.0-85048898631 | - |
dc.identifier.hkuros | 289540 | - |
dc.identifier.volume | 66 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 319 | - |
dc.identifier.epage | 324 | - |
dc.identifier.isi | WOS:000428919000007 | - |
dc.publisher.place | Canada | - |
dc.identifier.issnl | 1081-5589 | - |