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Article: Spatial-temporal transcriptional dynamics of long non-coding RNAs in human brain

TitleSpatial-temporal transcriptional dynamics of long non-coding RNAs in human brain
Authors
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2017, v. 26 n. 16, p. 3202-3211 How to Cite?
AbstractThe functional architecture of the human brain is greatly determined by the temporal and spatial regulation of the transcription process. However, the spatial and temporal transcriptional landscape of long non-coding RNAs (lncRNAs) during human brain development remains poorly understood. Here, we report the genome-wide lncRNA transcriptional analysis in an extensive series of 1340 post-mortem human brain specimens collected from 16 regions spanning the period from early embryo development to late adulthood. We discovered that lncRNA transcriptome dramatically changed during fetal development, while transited to a surprisingly relatively stable state after birth till the late adulthood. We also discovered that the transcription map of lncRNAs was spatially different, and that this spatial difference was developmentally regulated. Of the 16 brain regions explored (cerebellar cortex, thalamus, striatum, amygdala, hippocampus and 11 neocortex areas), cerebellar cortex showed the most distinct lncRNA expression features from all remaining brain regions throughout the whole developmental period, reflecting its unique developmental and functional features. Furthermore, by characterizing the functional modules and cellular processes of the spatial-temporal dynamic lncRNAs, we found that they were significantly associated with the RNA processing, neuron differentiation and synaptic signal transportation processes. Furthermore, we found that many lncRNAs associated with the neurodegenerative Alzheimer and Parkinson diseases were co-expressed in the fetal development of the human brain, and affected the convergent biological processes. In summary, our study provides a comprehensive map for lncRNA transcription dynamics in human brain development, which might shed light on the understanding of the molecular underpinnings of human brain function and disease.
Persistent Identifierhttp://hdl.handle.net/10722/259391
ISSN
2017 Impact Factor: 4.902
2015 SCImago Journal Rankings: 4.288
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, XQ-
dc.contributor.authorWang, Z-
dc.contributor.authorPoon, MW-
dc.contributor.authorYang, J-
dc.date.accessioned2018-09-03T04:06:40Z-
dc.date.available2018-09-03T04:06:40Z-
dc.date.issued2017-
dc.identifier.citationHuman Molecular Genetics, 2017, v. 26 n. 16, p. 3202-3211-
dc.identifier.issn0964-6906-
dc.identifier.urihttp://hdl.handle.net/10722/259391-
dc.description.abstractThe functional architecture of the human brain is greatly determined by the temporal and spatial regulation of the transcription process. However, the spatial and temporal transcriptional landscape of long non-coding RNAs (lncRNAs) during human brain development remains poorly understood. Here, we report the genome-wide lncRNA transcriptional analysis in an extensive series of 1340 post-mortem human brain specimens collected from 16 regions spanning the period from early embryo development to late adulthood. We discovered that lncRNA transcriptome dramatically changed during fetal development, while transited to a surprisingly relatively stable state after birth till the late adulthood. We also discovered that the transcription map of lncRNAs was spatially different, and that this spatial difference was developmentally regulated. Of the 16 brain regions explored (cerebellar cortex, thalamus, striatum, amygdala, hippocampus and 11 neocortex areas), cerebellar cortex showed the most distinct lncRNA expression features from all remaining brain regions throughout the whole developmental period, reflecting its unique developmental and functional features. Furthermore, by characterizing the functional modules and cellular processes of the spatial-temporal dynamic lncRNAs, we found that they were significantly associated with the RNA processing, neuron differentiation and synaptic signal transportation processes. Furthermore, we found that many lncRNAs associated with the neurodegenerative Alzheimer and Parkinson diseases were co-expressed in the fetal development of the human brain, and affected the convergent biological processes. In summary, our study provides a comprehensive map for lncRNA transcription dynamics in human brain development, which might shed light on the understanding of the molecular underpinnings of human brain function and disease.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/-
dc.relation.ispartofHuman Molecular Genetics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSpatial-temporal transcriptional dynamics of long non-coding RNAs in human brain-
dc.typeArticle-
dc.identifier.emailPoon, MW: ilmwpoon@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/hmg/ddx203-
dc.identifier.pmid28575308-
dc.identifier.hkuros289149-
dc.identifier.volume26-
dc.identifier.issue16-
dc.identifier.spage3202-
dc.identifier.epage3211-
dc.identifier.isiWOS:000406794000015-
dc.publisher.placeUnited Kingdom-

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