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Article: The Three S's for Aptamer-Mediated Control of DNA Nanostructure Dynamics: Shape, Self-Complementarity, and Spatial Flexibility

TitleThe Three S's for Aptamer-Mediated Control of DNA Nanostructure Dynamics: Shape, Self-Complementarity, and Spatial Flexibility
Authors
KeywordsDNA
aptamers
nanomachines
nanotechnology
structural optimization
Issue Date2018
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.chembiochem.com
Citation
ChemBioChem, 2018, p. 1-8 How to Cite?
AbstractDNA aptamers are ideal tools to enable modular control of the dynamics of DNA nanostructures. For molecular recognition, they have a particular advantage over antibodies in that they can be integrated into DNA nanostructures in a bespoke manner by base pairing or nucleotide extension without any complex bioconjugation strategy. Such simplicity will be critical upon considering advanced therapeutic and diagnostic applications of DNA nanostructures. However, optimizing DNA aptamers for functional control of the dynamics of DNA nanostructure can be challenging. Herein, we present three considerations-shape, self-complementarity, and spatial flexibility-that should be paramount upon optimizing aptamer functionality. These lessons, learnt from the growing number of aptamer-nanostructure reports thus far, will be helpful for future studies in which aptamers are used to control the dynamics of nucleic acid nanostructures.
Persistent Identifierhttp://hdl.handle.net/10722/259089
ISSN
2017 Impact Factor: 2.774
2015 SCImago Journal Rankings: 1.301
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShiu, CC-
dc.contributor.authorKinghorn, AB-
dc.contributor.authorSakai, Y-
dc.contributor.authorCheung, YW-
dc.contributor.authorHeddle, JG-
dc.contributor.authorTanner, JA-
dc.date.accessioned2018-09-03T04:01:20Z-
dc.date.available2018-09-03T04:01:20Z-
dc.date.issued2018-
dc.identifier.citationChemBioChem, 2018, p. 1-8-
dc.identifier.issn1439-4227-
dc.identifier.urihttp://hdl.handle.net/10722/259089-
dc.description.abstractDNA aptamers are ideal tools to enable modular control of the dynamics of DNA nanostructures. For molecular recognition, they have a particular advantage over antibodies in that they can be integrated into DNA nanostructures in a bespoke manner by base pairing or nucleotide extension without any complex bioconjugation strategy. Such simplicity will be critical upon considering advanced therapeutic and diagnostic applications of DNA nanostructures. However, optimizing DNA aptamers for functional control of the dynamics of DNA nanostructure can be challenging. Herein, we present three considerations-shape, self-complementarity, and spatial flexibility-that should be paramount upon optimizing aptamer functionality. These lessons, learnt from the growing number of aptamer-nanostructure reports thus far, will be helpful for future studies in which aptamers are used to control the dynamics of nucleic acid nanostructures.-
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.chembiochem.com-
dc.relation.ispartofChemBioChem-
dc.rightspostprint: This is the accepted version of the following article: FULL CITE, which has been published in final form at [Link to final article]. Preprint This is the pre-peer reviewed version of the following article: FULL CITE, which has been published in final form at [Link to final article].-
dc.subjectDNA-
dc.subjectaptamers-
dc.subjectnanomachines-
dc.subjectnanotechnology-
dc.subjectstructural optimization-
dc.titleThe Three S's for Aptamer-Mediated Control of DNA Nanostructure Dynamics: Shape, Self-Complementarity, and Spatial Flexibility-
dc.typeArticle-
dc.identifier.emailKinghorn, AB: kinghorn@hku.hk-
dc.identifier.emailCheung, YW: cheungw@hku.hk-
dc.identifier.emailTanner, JA: jatanner@hku.hk-
dc.identifier.authorityTanner, JA=rp00495-
dc.identifier.doi10.1002/cbic.201800308-
dc.identifier.pmid30007003-
dc.identifier.hkuros289825-
dc.identifier.spage1-
dc.identifier.epage8-
dc.identifier.isiWOS:000444798400001-
dc.publisher.placeGermany-

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