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Article: Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity

TitleCoordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity
Authors
KeywordsFgf
Morphogenesis
Mouse
PCP
Planar cell polarity
Vangl2
Wnt
Issue Date2018
PublisherCompany of Biologists.
Citation
Development, 2018, v. 145 n. 8, p. dev163824 How to Cite?
AbstractEmbryonic morphogenesis of a complex organism requires proper regulation of patterning and directional growth. Planar cell polarity (PCP) signaling is emerging as a crucial evolutionarily conserved mechanism whereby directional information is conveyed. PCP is thought to be established by global cues, and recent studies have revealed an instructive role of a Wnt signaling gradient in epithelial tissues of both invertebrates and vertebrates. However, it remains unclear whether Wnt/PCP signaling is regulated in a coordinated manner with embryonic patterning during morphogenesis. Here, in mouse developing limbs, we find that apical ectoderm ridge-derived Fgfs required for limb patterning regulate PCP along the proximal-distal axis in a Wnt5a-dependent manner. We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing PCP in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf signaling to orient PCP. Our results indicate that limb morphogenesis is regulated by coordination of directional growth and patterning through integration of Wnt5a and Fgf signaling.
Persistent Identifierhttp://hdl.handle.net/10722/259087
ISSN
2017 Impact Factor: 5.413
2015 SCImago Journal Rankings: 5.239
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, B-
dc.contributor.authorAjima, R-
dc.contributor.authorYang, W-
dc.contributor.authorLi, C-
dc.contributor.authorSong, H-
dc.contributor.authorAnderson, MJ-
dc.contributor.authorLiu, RR-
dc.contributor.authorLewandoski, MB-
dc.contributor.authorYamaguchi, TP-
dc.contributor.authorYang, Y-
dc.date.accessioned2018-09-03T04:01:17Z-
dc.date.available2018-09-03T04:01:17Z-
dc.date.issued2018-
dc.identifier.citationDevelopment, 2018, v. 145 n. 8, p. dev163824-
dc.identifier.issn0950-1991-
dc.identifier.urihttp://hdl.handle.net/10722/259087-
dc.description.abstractEmbryonic morphogenesis of a complex organism requires proper regulation of patterning and directional growth. Planar cell polarity (PCP) signaling is emerging as a crucial evolutionarily conserved mechanism whereby directional information is conveyed. PCP is thought to be established by global cues, and recent studies have revealed an instructive role of a Wnt signaling gradient in epithelial tissues of both invertebrates and vertebrates. However, it remains unclear whether Wnt/PCP signaling is regulated in a coordinated manner with embryonic patterning during morphogenesis. Here, in mouse developing limbs, we find that apical ectoderm ridge-derived Fgfs required for limb patterning regulate PCP along the proximal-distal axis in a Wnt5a-dependent manner. We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing PCP in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf signaling to orient PCP. Our results indicate that limb morphogenesis is regulated by coordination of directional growth and patterning through integration of Wnt5a and Fgf signaling.-
dc.languageeng-
dc.publisherCompany of Biologists.-
dc.relation.ispartofDevelopment-
dc.subjectFgf-
dc.subjectMorphogenesis-
dc.subjectMouse-
dc.subjectPCP-
dc.subjectPlanar cell polarity-
dc.subjectVangl2-
dc.subjectWnt-
dc.titleCoordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity-
dc.typeArticle-
dc.identifier.emailGao, B: gaobo@hku.hk-
dc.identifier.authorityGao, B=rp02012-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1242/dev.163824-
dc.identifier.pmid29615464-
dc.identifier.pmcidPMC5964654-
dc.identifier.hkuros289652-
dc.identifier.volume145-
dc.identifier.issue8-
dc.identifier.spagedev163824-
dc.identifier.epagedev163824-
dc.identifier.isiWOS:000438945600011-
dc.publisher.placeEngland-
dc.identifier.f1000732983743-

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