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Article: All optical interface for parallel, remote, and spatiotemporal control of neuronal activity

TitleAll optical interface for parallel, remote, and spatiotemporal control of neuronal activity
Authors
Issue Date2007
Citation
Nano Letters, 2007, v. 7, n. 12, p. 3859-3863 How to Cite?
AbstractA key technical barrier to furthering our understanding of complex neural networks has been the lack of tools for the simultaneous spatiotemporal control and detection of activity in a large number of-neurons. Here, we report an all-optical system for achieving this kind of parallel and selective control and detection. We do this by delivering spatiotemporally complex optical stimuli through a digital micromirror spatiotemporal light modulator to cells expressing the light-activated ionotropic glutamate receptor (LiGluR), which have been labeled with a calcium dye to provide a fluorescent report of activity. Reliable and accurate spatiotemporal stimulation was obtained on HEK293 cells and cultured rat hippocampal neurons. This technique should be adaptable to in vivo applications and could serve as an optical interface for communicating with complex neural circuits. © 2007 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/257306
ISSN
2015 Impact Factor: 13.779
2015 SCImago Journal Rankings: 9.006

 

DC FieldValueLanguage
dc.contributor.authorWang, Sheng-
dc.contributor.authorSzobota, Stephanie-
dc.contributor.authorWang, Yuan-
dc.contributor.authorVolgraf, Matthew-
dc.contributor.authorLiu, Zhaowei-
dc.contributor.authorSun, Cheng-
dc.contributor.authorTrauner, Dirk-
dc.contributor.authorIsacoff, Ehud Y.-
dc.contributor.authorZhang, Xiang-
dc.date.accessioned2018-07-24T08:59:25Z-
dc.date.available2018-07-24T08:59:25Z-
dc.date.issued2007-
dc.identifier.citationNano Letters, 2007, v. 7, n. 12, p. 3859-3863-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/257306-
dc.description.abstractA key technical barrier to furthering our understanding of complex neural networks has been the lack of tools for the simultaneous spatiotemporal control and detection of activity in a large number of-neurons. Here, we report an all-optical system for achieving this kind of parallel and selective control and detection. We do this by delivering spatiotemporally complex optical stimuli through a digital micromirror spatiotemporal light modulator to cells expressing the light-activated ionotropic glutamate receptor (LiGluR), which have been labeled with a calcium dye to provide a fluorescent report of activity. Reliable and accurate spatiotemporal stimulation was obtained on HEK293 cells and cultured rat hippocampal neurons. This technique should be adaptable to in vivo applications and could serve as an optical interface for communicating with complex neural circuits. © 2007 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofNano Letters-
dc.titleAll optical interface for parallel, remote, and spatiotemporal control of neuronal activity-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1021/nl072783t-
dc.identifier.pmid18034506-
dc.identifier.scopuseid_2-s2.0-38049109866-
dc.identifier.volume7-
dc.identifier.issue12-
dc.identifier.spage3859-
dc.identifier.epage3863-

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