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Article: Local plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2

TitleLocal plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2
Authors
Issue Date2014
Citation
PLoS ONE, 2014, v. 9, n. 1 How to Cite?
AbstractWhile plasticity is typically associated with persistent modifications of synaptic strengths, recent studies indicated that modulations of dendritic excitability may form the other part of the engram and dynamically affect computational processing and output of neuronal circuits. However it remains unknown whether modulation of dendritic excitability is controlled by synaptic changes or whether it can be distinct from them. Here we report the first observation of the induction of a persistent plastic decrease in dendritic excitability decoupled from synaptic stimulation, which is localized and purely activity-based. In rats this local plasticity decrease is conferred by CamKII mediated phosphorylation of A-type potassium channels upon interaction of a back propagating action potential (bAP) with dendritic depolarization. © 2014 Labno et al.
Persistent Identifierhttp://hdl.handle.net/10722/257123
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLabno, Anna-
dc.contributor.authorWarrier, Ajithkumar-
dc.contributor.authorWang, Sheng-
dc.contributor.authorZhang, Xiang-
dc.date.accessioned2018-07-24T08:58:54Z-
dc.date.available2018-07-24T08:58:54Z-
dc.date.issued2014-
dc.identifier.citationPLoS ONE, 2014, v. 9, n. 1-
dc.identifier.urihttp://hdl.handle.net/10722/257123-
dc.description.abstractWhile plasticity is typically associated with persistent modifications of synaptic strengths, recent studies indicated that modulations of dendritic excitability may form the other part of the engram and dynamically affect computational processing and output of neuronal circuits. However it remains unknown whether modulation of dendritic excitability is controlled by synaptic changes or whether it can be distinct from them. Here we report the first observation of the induction of a persistent plastic decrease in dendritic excitability decoupled from synaptic stimulation, which is localized and purely activity-based. In rats this local plasticity decrease is conferred by CamKII mediated phosphorylation of A-type potassium channels upon interaction of a back propagating action potential (bAP) with dendritic depolarization. © 2014 Labno et al.-
dc.languageeng-
dc.relation.ispartofPLoS ONE-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleLocal plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0084086-
dc.identifier.pmid24404150-
dc.identifier.scopuseid_2-s2.0-84896797129-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn1932-6203-
dc.identifier.isiWOS:000329460800029-

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