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Article: Self-amplifying autocrine actions of BDNF in axon development

TitleSelf-amplifying autocrine actions of BDNF in axon development
Authors
KeywordsNeurotrophin autocrine loops
Trk redistribution
cAMP/protein kinase A elevation
Axon initiation and growth
Issue Date2011
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2011, v. 108, n. 45, p. 18430-18435 How to Cite?
AbstractA critical step in neuronal development is the formation of axon/ dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local self-amplifying processes could enhance and stabilize the initial asymmetry in the distribution of axon/dendrite determinants, but the identity of these processes remains elusive. We here report that BDNF, a secreted neurotrophin essential for the survival and differentiation ofmany neuronal populations, serves as a self-amplifying autocrine factor in promoting axon formation in embryonic hippocampal neurons by triggering two nested positive-feedback mechanisms. First, BDNF elevates cytoplasmic cAMP and protein kinase A activity, which triggers further secretion of BDNF and membrane insertion of its receptor TrkB. Second, BDNF/TrkB signaling activates PI3-kinase that promotes anterograde transport of TrkB in the putative axon, further enhancing local BDNF/TrkB signaling. Together, these self-amplifying BDNF actions ensure stable elevation of local cAMP/protein kinase A activity that is critical for axon differentiation and growth.
Persistent Identifierhttp://hdl.handle.net/10722/257086
ISSN
2017 Impact Factor: 9.504
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, Pei Lin-
dc.contributor.authorSong, Ai Hong-
dc.contributor.authorWong, Yu Hui-
dc.contributor.authorWang, Sheng-
dc.contributor.authorZhang, Xiang-
dc.contributor.authorPoo, Mu Ming-
dc.date.accessioned2018-07-24T08:58:48Z-
dc.date.available2018-07-24T08:58:48Z-
dc.date.issued2011-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2011, v. 108, n. 45, p. 18430-18435-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/257086-
dc.description.abstractA critical step in neuronal development is the formation of axon/ dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local self-amplifying processes could enhance and stabilize the initial asymmetry in the distribution of axon/dendrite determinants, but the identity of these processes remains elusive. We here report that BDNF, a secreted neurotrophin essential for the survival and differentiation ofmany neuronal populations, serves as a self-amplifying autocrine factor in promoting axon formation in embryonic hippocampal neurons by triggering two nested positive-feedback mechanisms. First, BDNF elevates cytoplasmic cAMP and protein kinase A activity, which triggers further secretion of BDNF and membrane insertion of its receptor TrkB. Second, BDNF/TrkB signaling activates PI3-kinase that promotes anterograde transport of TrkB in the putative axon, further enhancing local BDNF/TrkB signaling. Together, these self-amplifying BDNF actions ensure stable elevation of local cAMP/protein kinase A activity that is critical for axon differentiation and growth.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.subjectNeurotrophin autocrine loops-
dc.subjectTrk redistribution-
dc.subjectcAMP/protein kinase A elevation-
dc.subjectAxon initiation and growth-
dc.titleSelf-amplifying autocrine actions of BDNF in axon development-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.1115907108-
dc.identifier.pmid22025720-
dc.identifier.scopuseid_2-s2.0-81055130093-
dc.identifier.volume108-
dc.identifier.issue45-
dc.identifier.spage18430-
dc.identifier.epage18435-
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000296700000056-
dc.identifier.f100014267289-

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