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Article: A signal processing analysis of Purkinje cells in vitro

TitleA signal processing analysis of Purkinje cells in vitro
Authors
KeywordsPurkinje cell
Optical activation
Calcium spikes
Signal processing
Rhythmicity
Oscillations
Issue Date2010
Citation
Frontiers in Neural Circuits, 2010, v. 4 How to Cite?
AbstractCerebellar Purkinje cells in vitro fi re recurrent sequences of Sodium and Calcium spikes. Here, we analyze the Purkinje cell using harmonic analysis, and our experiments reveal that its output signal is comprised of three distinct frequency bands, which are combined using Amplitude and Frequency Modulation (AM/FM). We fi nd that the three characteristic frequencies - Sodium, Calcium and Switching - occur in various combinations in all waveforms observed using wholecell current clamp recordings. We found that the Calcium frequency can display a frequency doubling of its frequency mode, and the Switching frequency can act as a possible generator of pauses that are typically seen in Purkinje output recordings. Using a reversibly photoswitchable kainate receptor agonist, we demonstrate the external modulation of the Calcium and Switching frequencies. These experiments and Fourier analysis suggest that the Purkinje cell can be understood as a harmonic signal oscillator, enabling a higher level of interpretation of Purkinje signaling based on modern signal processing techniques.
Persistent Identifierhttp://hdl.handle.net/10722/257029
ISSN
2015 Impact Factor: 3.879
2015 SCImago Journal Rankings: 1.992

 

DC FieldValueLanguage
dc.contributor.authorAbrams, Ze'ev R.-
dc.contributor.authorWarrier, Ajithkumar-
dc.contributor.authorTrauner, Dirk-
dc.contributor.authorZhang, Xiang-
dc.date.accessioned2018-07-24T08:58:37Z-
dc.date.available2018-07-24T08:58:37Z-
dc.date.issued2010-
dc.identifier.citationFrontiers in Neural Circuits, 2010, v. 4-
dc.identifier.issn1662-5110-
dc.identifier.urihttp://hdl.handle.net/10722/257029-
dc.description.abstractCerebellar Purkinje cells in vitro fi re recurrent sequences of Sodium and Calcium spikes. Here, we analyze the Purkinje cell using harmonic analysis, and our experiments reveal that its output signal is comprised of three distinct frequency bands, which are combined using Amplitude and Frequency Modulation (AM/FM). We fi nd that the three characteristic frequencies - Sodium, Calcium and Switching - occur in various combinations in all waveforms observed using wholecell current clamp recordings. We found that the Calcium frequency can display a frequency doubling of its frequency mode, and the Switching frequency can act as a possible generator of pauses that are typically seen in Purkinje output recordings. Using a reversibly photoswitchable kainate receptor agonist, we demonstrate the external modulation of the Calcium and Switching frequencies. These experiments and Fourier analysis suggest that the Purkinje cell can be understood as a harmonic signal oscillator, enabling a higher level of interpretation of Purkinje signaling based on modern signal processing techniques.-
dc.languageeng-
dc.relation.ispartofFrontiers in Neural Circuits-
dc.subjectPurkinje cell-
dc.subjectOptical activation-
dc.subjectCalcium spikes-
dc.subjectSignal processing-
dc.subjectRhythmicity-
dc.subjectOscillations-
dc.titleA signal processing analysis of Purkinje cells in vitro-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.3389/fncir.2010.00013-
dc.identifier.scopuseid_2-s2.0-77953454561-
dc.identifier.volume4-
dc.identifier.spagenull-
dc.identifier.epagenull-

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