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Article: Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study

TitleCancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study
Authors
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://journals.lww.com/ibdjournal/pages/default.aspx
Citation
Inflammatory Bowel Diseases, 2017, v. 23, p. 2061-2068 How to Cite?
AbstractBACKGROUND: Studies on cancer risk in inflammatory bowel disease (IBD) have yielded inconsistent results. We conducted a population-based study to determine the risk of cancer in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Using a territory-wide IBD registry in Hong Kong, we identified 2621 patients with IBD and no history of cancer from 1990 to 2016. We followed them from diagnosis until either September 2016, cancer development, proctocolectomy, or death. Standardized incidence ratios (SIRs) of overall cancer and site-specific cancers were calculated. RESULTS: Of 2621 patients with IBD (1108 CD; 1603 UC; median age, 49 yr; 59.5% men) followed for 26,234 person-years, 88 patients developed cancer after IBD diagnosis. Patients with CD had an increased risk of anorectal cancers (SIR 4.11; 95% confidence interval (CI), 1.84-9.14) and hematological cancers (SIR 3.86, 95% CI, 1.61-9.27) including leukemia (SIR 5.98; 95% CI, 1.93-18.54). Nonmelanoma skin cancer was significantly increased in both CD and UC (CD: SIR 13.88; 95% CI, 1.95-98.51; UC: SIR 9.05; 95% CI, 2.26-36.19). Patients with CD had a higher risk of renal-cell carcinoma (SIR 6.89; 95% CI, 2.22-21.37), and patients with UC had a higher risk of prostate cancer (SIR 2.47; 95% CI, 1.24-4.95). CONCLUSIONS: In a population-based study, Chinese patients with CD are at an increased risk of anorectal cancers and hematological cancers compared with the general population. A higher risk of nonmelanoma skin cancer was also observed in CD and UC. Cancer surveillance should be considered.
Persistent Identifierhttp://hdl.handle.net/10722/256351
ISSN
2015 Impact Factor: 4.358
2015 SCImago Journal Rankings: 1.994

 

DC FieldValueLanguage
dc.contributor.authorSo, J-
dc.contributor.authorTang, W-
dc.contributor.authorLeung, WK-
dc.contributor.authorLi, M-
dc.contributor.authorLo, FH-
dc.contributor.authorWong, MTL-
dc.contributor.authorSze, ASF-
dc.contributor.authorLeung, CM-
dc.contributor.authorTsang, SWC-
dc.contributor.authorShan, EHS-
dc.contributor.authorChan, KH-
dc.contributor.authorLam, BCY-
dc.contributor.authorHui, AJ-
dc.contributor.authorChow, WH-
dc.contributor.authorLam, TY-
dc.contributor.authorLam, V-
dc.contributor.authorLee, TW-
dc.contributor.authorLo, HHH-
dc.contributor.authorTang, CM-
dc.contributor.authorWong, CL-
dc.contributor.authorWu, JCY-
dc.contributor.authorChan, FKL-
dc.contributor.authorSung, JJY-
dc.contributor.authorHarbord, M-
dc.contributor.authorNg, SC-
dc.date.accessioned2018-07-20T06:33:17Z-
dc.date.available2018-07-20T06:33:17Z-
dc.date.issued2017-
dc.identifier.citationInflammatory Bowel Diseases, 2017, v. 23, p. 2061-2068-
dc.identifier.issn1078-0998-
dc.identifier.urihttp://hdl.handle.net/10722/256351-
dc.description.abstractBACKGROUND: Studies on cancer risk in inflammatory bowel disease (IBD) have yielded inconsistent results. We conducted a population-based study to determine the risk of cancer in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Using a territory-wide IBD registry in Hong Kong, we identified 2621 patients with IBD and no history of cancer from 1990 to 2016. We followed them from diagnosis until either September 2016, cancer development, proctocolectomy, or death. Standardized incidence ratios (SIRs) of overall cancer and site-specific cancers were calculated. RESULTS: Of 2621 patients with IBD (1108 CD; 1603 UC; median age, 49 yr; 59.5% men) followed for 26,234 person-years, 88 patients developed cancer after IBD diagnosis. Patients with CD had an increased risk of anorectal cancers (SIR 4.11; 95% confidence interval (CI), 1.84-9.14) and hematological cancers (SIR 3.86, 95% CI, 1.61-9.27) including leukemia (SIR 5.98; 95% CI, 1.93-18.54). Nonmelanoma skin cancer was significantly increased in both CD and UC (CD: SIR 13.88; 95% CI, 1.95-98.51; UC: SIR 9.05; 95% CI, 2.26-36.19). Patients with CD had a higher risk of renal-cell carcinoma (SIR 6.89; 95% CI, 2.22-21.37), and patients with UC had a higher risk of prostate cancer (SIR 2.47; 95% CI, 1.24-4.95). CONCLUSIONS: In a population-based study, Chinese patients with CD are at an increased risk of anorectal cancers and hematological cancers compared with the general population. A higher risk of nonmelanoma skin cancer was also observed in CD and UC. Cancer surveillance should be considered.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://journals.lww.com/ibdjournal/pages/default.aspx-
dc.relation.ispartofInflammatory Bowel Diseases-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. -
dc.titleCancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study-
dc.typeArticle-
dc.identifier.emailLeung, WK: waikleung@hku.hk-
dc.identifier.authorityLeung, WK=rp01479-
dc.identifier.doi10.1097/MIB.0000000000001240-
dc.identifier.hkuros286027-
dc.identifier.volume23-
dc.identifier.spage2061-
dc.identifier.epage2068-
dc.publisher.placeUnited States-

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