File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.cclet.2018.03.012
- Scopus: eid_2-s2.0-85044160137
- WOS: WOS:000438004700021
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Development of aspartic acid ligation for peptide cyclization derived from serine/threonine ligation
Title | Development of aspartic acid ligation for peptide cyclization derived from serine/threonine ligation |
---|---|
Authors | |
Keywords | Aspartic acid ligation Peptide cyclization Serine/threonine ligation Ring-chain tautomerization Acyl transfer Selective oxidation |
Issue Date | 2018 |
Publisher | Elsevier Ltd for Chinese Chemical Society. The Journal's web site is located at http://www.chinchemlett.com.cn |
Citation | Chinese Chemical Letters, 2018, v. 29 n. 7, p. 1119-1122 How to Cite? |
Abstract | Based on a mechanism analogous to the serine/threonine ligation, the aspartic acid ligation, which is facilitated by the γ-amino alcohol based ligation and oxidation, is developed and applied to the synthesis of cyclic peptides. The γ-hydroxyl group triggers the ring-chain tautomerization via a 6-endo-trig process, while the δ-hydroxyl group facilitates the oxidative cleavage of the vicinal diol to give carboxylic acid. |
Persistent Identifier | http://hdl.handle.net/10722/256267 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 1.662 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, C | - |
dc.contributor.author | Xu, J | - |
dc.contributor.author | Liu, H | - |
dc.contributor.author | Li, X | - |
dc.date.accessioned | 2018-07-20T06:31:57Z | - |
dc.date.available | 2018-07-20T06:31:57Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Chinese Chemical Letters, 2018, v. 29 n. 7, p. 1119-1122 | - |
dc.identifier.issn | 1001-8417 | - |
dc.identifier.uri | http://hdl.handle.net/10722/256267 | - |
dc.description.abstract | Based on a mechanism analogous to the serine/threonine ligation, the aspartic acid ligation, which is facilitated by the γ-amino alcohol based ligation and oxidation, is developed and applied to the synthesis of cyclic peptides. The γ-hydroxyl group triggers the ring-chain tautomerization via a 6-endo-trig process, while the δ-hydroxyl group facilitates the oxidative cleavage of the vicinal diol to give carboxylic acid. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd for Chinese Chemical Society. The Journal's web site is located at http://www.chinchemlett.com.cn | - |
dc.relation.ispartof | Chinese Chemical Letters | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Aspartic acid ligation | - |
dc.subject | Peptide cyclization | - |
dc.subject | Serine/threonine ligation | - |
dc.subject | Ring-chain tautomerization | - |
dc.subject | Acyl transfer | - |
dc.subject | Selective oxidation | - |
dc.title | Development of aspartic acid ligation for peptide cyclization derived from serine/threonine ligation | - |
dc.type | Article | - |
dc.identifier.email | Liu, H: liuhan@HKUCC-COM.hku.hk | - |
dc.identifier.email | Li, X: xuechenl@hku.hk | - |
dc.identifier.authority | Liu, H=rp02748 | - |
dc.identifier.authority | Li, X=rp00742 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.cclet.2018.03.012 | - |
dc.identifier.scopus | eid_2-s2.0-85044160137 | - |
dc.identifier.hkuros | 286399 | - |
dc.identifier.volume | 29 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1119 | - |
dc.identifier.epage | 1122 | - |
dc.identifier.isi | WOS:000438004700021 | - |
dc.publisher.place | China | - |
dc.identifier.issnl | 1001-8417 | - |