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Article: Cell fate reprogramming through engineering of native transcription factors
Title | Cell fate reprogramming through engineering of native transcription factors |
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Authors | |
Issue Date | 2018 |
Publisher | Elsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/gde |
Citation | Current Opinion in Genetics & Development, 2018, v. 52, p. 109-116 How to Cite? |
Abstract | Cellular reprogramming using cocktails of transcription factors (TFs) affirms the epigenetic and developmental plasticity of mammalian cells. It demonstrates the ability of TFs to ‘read’ genetic information and to rewire regulatory networks in different cellular contexts. Silenced chromatin is not an impediment to the genome engagement by ectopically expressed TFs. Reprogramming TFs have been identified in diverse structural families that lack shared domains or sequence motifs. Interestingly, the reprogramming activity of non-redundant paralogous TFs can be switched with a few point mutations. These findings revealed that the sequence–function relationships influencing reprogramming are tied to subtle features directing genome wide binding. Therefore, endogenous reprogramming TFs are amenable to directed biomolecular engineering that opens up new avenues to optimize cell fate conversions. |
Persistent Identifier | http://hdl.handle.net/10722/256200 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 2.510 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jauch, R | - |
dc.date.accessioned | 2018-07-20T06:30:54Z | - |
dc.date.available | 2018-07-20T06:30:54Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Current Opinion in Genetics & Development, 2018, v. 52, p. 109-116 | - |
dc.identifier.issn | 0959-437X | - |
dc.identifier.uri | http://hdl.handle.net/10722/256200 | - |
dc.description.abstract | Cellular reprogramming using cocktails of transcription factors (TFs) affirms the epigenetic and developmental plasticity of mammalian cells. It demonstrates the ability of TFs to ‘read’ genetic information and to rewire regulatory networks in different cellular contexts. Silenced chromatin is not an impediment to the genome engagement by ectopically expressed TFs. Reprogramming TFs have been identified in diverse structural families that lack shared domains or sequence motifs. Interestingly, the reprogramming activity of non-redundant paralogous TFs can be switched with a few point mutations. These findings revealed that the sequence–function relationships influencing reprogramming are tied to subtle features directing genome wide binding. Therefore, endogenous reprogramming TFs are amenable to directed biomolecular engineering that opens up new avenues to optimize cell fate conversions. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/gde | - |
dc.relation.ispartof | Current Opinion in Genetics & Development | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Cell fate reprogramming through engineering of native transcription factors | - |
dc.type | Article | - |
dc.identifier.email | Jauch, R: ralf@hku.hk | - |
dc.identifier.authority | Jauch, R=rp02383 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.gde.2018.05.013 | - |
dc.identifier.scopus | eid_2-s2.0-85049334251 | - |
dc.identifier.hkuros | 286403 | - |
dc.identifier.volume | 52 | - |
dc.identifier.spage | 109 | - |
dc.identifier.epage | 116 | - |
dc.identifier.isi | WOS:000450625900017 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0959-437X | - |