File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Discovery and sequence analysis of four deltacoronaviruses from birds in the Middle East suggest interspecies jumping and recombination as potential mechanism for avian-to-avian and avian-to-mammalian transmission

TitleDiscovery and sequence analysis of four deltacoronaviruses from birds in the Middle East suggest interspecies jumping and recombination as potential mechanism for avian-to-avian and avian-to-mammalian transmission
Authors
KeywordsCoronavirus
Deltacoronavirus
Falcon
Houbara bustard
Interspecies jumping
Issue Date2018
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2018, v. 92 n. 15, p. e00265:1-e00265:18 How to Cite?
AbstractThe emergence of Middle East respiratory syndrome showed once again that coronaviruses (CoVs) in animals are potential source for epidemics in humans. To explore the diversity of deltacoronaviruses in animals in the Middle East, we tested fecal samples from 1,356 mammals and birds in Dubai, The United Arab Emirates. Four novel deltacoronaviruses were detected from eight birds of four species by reverse transcription-PCR (RT-PCR): FalCoV UAE-HKU27 from a falcon, HouCoV UAE-HKU28 from a houbara bustard, PiCoV UAE-HKU29 from a pigeon, and QuaCoV UAE-HKU30 from five quails. Complete genome sequencing showed that FalCoV UAE-HKU27, HouCoV UAE-HKU28, and PiCoV UAEHKU29 belong to the same CoV species, suggesting recent interspecies transmission between falcons and their prey, houbara bustards and pigeons, possibly along the food chain. Western blotting detected specific anti-FalCoV UAE-HKU27 antibodies in 33 (75%) of 44 falcon serum samples, supporting genuine infection in falcons after virus acquisition. QuaCoV UAE-HKU30 belongs to the same CoV species as porcine coronavirus HKU15 (PorCoV HKU15) and sparrow coronavirus HKU17 (SpCoV HKU17), discovered previously from swine and tree sparrows, respectively, supporting avian-to-swine transmission. Recombination involving the spike protein is common among deltacoronaviruses, which may facilitate crossspecies transmission. FalCoV UAE-HKU27, HouCoV UAE-HKU28, and PiCoV UAEHKU29 originated from recombination between white-eye coronavirus HKU16 (WECoV HKU16) and magpie robin coronavirus HKU18 (MRCoV HKU18), QuaCoV UAE-HKU30 from recombination between PorCoV HKU15/SpCoV HKU17 and munia coronavirus HKU13 (MunCoV HKU13), and PorCoV HKU15 from recombination between SpCoV HKU17 and bulbul coronavirus HKU11 (BuCoV HKU11). Birds in the Middle East are hosts for diverse deltacoronaviruses with potential for interspecies transmission.
Persistent Identifierhttp://hdl.handle.net/10722/254943
ISSN
2019 Impact Factor: 4.501
2015 SCImago Journal Rankings: 3.347
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, SKP-
dc.contributor.authorWong, YM-
dc.contributor.authorTsang, CC-
dc.contributor.authorAhmed, SS-
dc.contributor.authorAu Yeung, KHR-
dc.contributor.authorYuen, KY-
dc.contributor.authorWernery, U-
dc.contributor.authorWoo, PCY-
dc.date.accessioned2018-06-21T01:09:00Z-
dc.date.available2018-06-21T01:09:00Z-
dc.date.issued2018-
dc.identifier.citationJournal of Virology, 2018, v. 92 n. 15, p. e00265:1-e00265:18-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/254943-
dc.description.abstractThe emergence of Middle East respiratory syndrome showed once again that coronaviruses (CoVs) in animals are potential source for epidemics in humans. To explore the diversity of deltacoronaviruses in animals in the Middle East, we tested fecal samples from 1,356 mammals and birds in Dubai, The United Arab Emirates. Four novel deltacoronaviruses were detected from eight birds of four species by reverse transcription-PCR (RT-PCR): FalCoV UAE-HKU27 from a falcon, HouCoV UAE-HKU28 from a houbara bustard, PiCoV UAE-HKU29 from a pigeon, and QuaCoV UAE-HKU30 from five quails. Complete genome sequencing showed that FalCoV UAE-HKU27, HouCoV UAE-HKU28, and PiCoV UAEHKU29 belong to the same CoV species, suggesting recent interspecies transmission between falcons and their prey, houbara bustards and pigeons, possibly along the food chain. Western blotting detected specific anti-FalCoV UAE-HKU27 antibodies in 33 (75%) of 44 falcon serum samples, supporting genuine infection in falcons after virus acquisition. QuaCoV UAE-HKU30 belongs to the same CoV species as porcine coronavirus HKU15 (PorCoV HKU15) and sparrow coronavirus HKU17 (SpCoV HKU17), discovered previously from swine and tree sparrows, respectively, supporting avian-to-swine transmission. Recombination involving the spike protein is common among deltacoronaviruses, which may facilitate crossspecies transmission. FalCoV UAE-HKU27, HouCoV UAE-HKU28, and PiCoV UAEHKU29 originated from recombination between white-eye coronavirus HKU16 (WECoV HKU16) and magpie robin coronavirus HKU18 (MRCoV HKU18), QuaCoV UAE-HKU30 from recombination between PorCoV HKU15/SpCoV HKU17 and munia coronavirus HKU13 (MunCoV HKU13), and PorCoV HKU15 from recombination between SpCoV HKU17 and bulbul coronavirus HKU11 (BuCoV HKU11). Birds in the Middle East are hosts for diverse deltacoronaviruses with potential for interspecies transmission.-
dc.languageeng-
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/-
dc.relation.ispartofJournal of Virology-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.subjectCoronavirus-
dc.subjectDeltacoronavirus-
dc.subjectFalcon-
dc.subjectHoubara bustard-
dc.subjectInterspecies jumping-
dc.titleDiscovery and sequence analysis of four deltacoronaviruses from birds in the Middle East suggest interspecies jumping and recombination as potential mechanism for avian-to-avian and avian-to-mammalian transmission-
dc.typeArticle-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailTsang, CC: microbioct@connect.hku.hk-
dc.identifier.emailAhmed, SS: ssahmed@hku.hk-
dc.identifier.emailAu Yeung, KHR: rex.auyeung@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityAu Yeung, KHR=rp01877-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityWoo, PCY=rp00430-
dc.description.naturepostprint-
dc.identifier.doi10.1128/JVI.00265-18-
dc.identifier.scopuseid_2-s2.0-85050153372-
dc.identifier.hkuros285440-
dc.identifier.volume92-
dc.identifier.issue15-
dc.identifier.spagee00265:1-
dc.identifier.epagee00265:18-
dc.identifier.isiWOS:000438967900002-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats