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Article: Deregulation of Frizzled Receptors in Hepatocellular Carcinoma

TitleDeregulation of Frizzled Receptors in Hepatocellular Carcinoma
Authors
KeywordsFrizzled receptors
G protein-coupled receptors
Wnt signaling
hepatocellular carcinoma
Issue Date2018
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2018, v. 19 n. 1, article no. E313 How to Cite?
AbstractG protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a 'cancer driver'. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway is frequently activated and it is associated with an aggressive HCC phenotype. Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. We also further review and highlight the potential targeting of FZD receptors as an alternative therapeutic strategy in HCC.
Persistent Identifierhttp://hdl.handle.net/10722/254922
ISSN
2017 Impact Factor: 3.687
2015 SCImago Journal Rankings: 1.160
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorChan, KK-
dc.contributor.authorLo, CLR-
dc.date.accessioned2018-06-21T01:08:40Z-
dc.date.available2018-06-21T01:08:40Z-
dc.date.issued2018-
dc.identifier.citationInternational Journal of Molecular Sciences, 2018, v. 19 n. 1, article no. E313-
dc.identifier.issn1422-0067-
dc.identifier.urihttp://hdl.handle.net/10722/254922-
dc.description.abstractG protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a 'cancer driver'. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway is frequently activated and it is associated with an aggressive HCC phenotype. Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. We also further review and highlight the potential targeting of FZD receptors as an alternative therapeutic strategy in HCC.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFrizzled receptors-
dc.subjectG protein-coupled receptors-
dc.subjectWnt signaling-
dc.subjecthepatocellular carcinoma-
dc.titleDeregulation of Frizzled Receptors in Hepatocellular Carcinoma-
dc.typeArticle-
dc.identifier.emailChan, KK: kuiasdf@hkucc.hk-
dc.identifier.emailLo, CLR: loregina@hku.hk-
dc.identifier.authorityLo, CLR=rp01359-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms19010313-
dc.identifier.pmid29361730-
dc.identifier.pmcidPMC5796257-
dc.identifier.scopuseid_2-s2.0-85040914014-
dc.identifier.hkuros285481-
dc.identifier.hkuros290170-
dc.identifier.volume19-
dc.identifier.issue1-
dc.identifier.spagearticle no. E313-
dc.identifier.epagearticle no. E313-
dc.publisher.placeSwitzerland-

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