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Conference Paper: Tobacco exposure in adolescence and the risk of nasopharyngeal carcinoma: preliminary results from a multi-center case-control study in Hong Kong, China

TitleTobacco exposure in adolescence and the risk of nasopharyngeal carcinoma: preliminary results from a multi-center case-control study in Hong Kong, China
Authors
Issue Date2018
PublisherBioMed Central Ltd. The Journal's web site is located at http://isptid.globalink.org/journal/index.html
Citation
The 17th World Conference on Tobacco or Health (WCTOH 2018), Cape Town, South Africa, 7-9 March 2018. In Tobacco Induced Diseases, 2018, v. 16 n. suppl. 1, p. 312, abstract no. A818 How to Cite?
AbstractBackground: Incidence of many cancers increases with age, but the incidence of nasopharyngeal carcinoma (NPC) in high-risk areas (e.g. Hong Kong) peaks at age 40-55 years. The early onset suggests an important role of early childhood exposures in NPC development. In our ongoing NPC case-control study, we examined the relationship between tobacco exposure especially in adolescence and NPC. Methods: We analysed 777 histologically confirmed NPC cases (mean age=52.8, SD=12.0), and 1,690 frequency matched non-NPC controls (mean age=50.4, SD=13.4) recruited during July 2014 to July 2017 from 5 of the largest hospitals (n=1,460) and 3 Red Cross Blood Transfusion Centres (n=230) in Hong Kong. Information on smoking and other factors was collected via a computer-assisted self-administered questionnaire. Re-interviewing of the 140 subjects showed good agreement of smoking history (Kappa or ICC: 0.65-0.99). Unconditional logistic regression was used to estimate odds ratios (ORs) of NPC for tobacco exposure, adjusting for 5-year age groups, sex, housing type at age 10, and alcohol drinking status. Results: Compared with never smokers, the OR (95%CIs) was 1.62 (1.32-1.98) for ever-smokers. The ORs were 2.27 (1.38-3.75) for starting smoking at 6-12 years and 1.65 (1.30-2.10) for 13-18 years (p for trend=0.001). For those who started at 6-18 years, the OR was 1.23 (0.79-1.93) for smoking 1-5 cigarettes/day, 1.71 (1.21-2.41) for 6-10 cigarettes/day and 1.78 (1.26-2.53) for 11+ cigarettes/day (p for trend< 0.001). Conclusions: Our preliminary results have shown that tobacco exposure in adolescence were associated with higher risk of NPC in a high-risk area. Further analysis will be conducted after case (target=800) and control (target=1900) recruitment is completed.
Description4.2. Burden and Disparities in tobacco-related diseases: Non-communicable diseases (NCDs) and communicable diseases (TB and HIV/AIDS) - FO-393-4
Persistent Identifierhttp://hdl.handle.net/10722/253521
ISSN
2017 Impact Factor: 1.539
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLIN, J-
dc.contributor.authorMAI, Z-
dc.contributor.authorLam, TH-
dc.date.accessioned2018-05-21T02:59:02Z-
dc.date.available2018-05-21T02:59:02Z-
dc.date.issued2018-
dc.identifier.citationThe 17th World Conference on Tobacco or Health (WCTOH 2018), Cape Town, South Africa, 7-9 March 2018. In Tobacco Induced Diseases, 2018, v. 16 n. suppl. 1, p. 312, abstract no. A818-
dc.identifier.issn1617-9625-
dc.identifier.urihttp://hdl.handle.net/10722/253521-
dc.description4.2. Burden and Disparities in tobacco-related diseases: Non-communicable diseases (NCDs) and communicable diseases (TB and HIV/AIDS) - FO-393-4-
dc.description.abstractBackground: Incidence of many cancers increases with age, but the incidence of nasopharyngeal carcinoma (NPC) in high-risk areas (e.g. Hong Kong) peaks at age 40-55 years. The early onset suggests an important role of early childhood exposures in NPC development. In our ongoing NPC case-control study, we examined the relationship between tobacco exposure especially in adolescence and NPC. Methods: We analysed 777 histologically confirmed NPC cases (mean age=52.8, SD=12.0), and 1,690 frequency matched non-NPC controls (mean age=50.4, SD=13.4) recruited during July 2014 to July 2017 from 5 of the largest hospitals (n=1,460) and 3 Red Cross Blood Transfusion Centres (n=230) in Hong Kong. Information on smoking and other factors was collected via a computer-assisted self-administered questionnaire. Re-interviewing of the 140 subjects showed good agreement of smoking history (Kappa or ICC: 0.65-0.99). Unconditional logistic regression was used to estimate odds ratios (ORs) of NPC for tobacco exposure, adjusting for 5-year age groups, sex, housing type at age 10, and alcohol drinking status. Results: Compared with never smokers, the OR (95%CIs) was 1.62 (1.32-1.98) for ever-smokers. The ORs were 2.27 (1.38-3.75) for starting smoking at 6-12 years and 1.65 (1.30-2.10) for 13-18 years (p for trend=0.001). For those who started at 6-18 years, the OR was 1.23 (0.79-1.93) for smoking 1-5 cigarettes/day, 1.71 (1.21-2.41) for 6-10 cigarettes/day and 1.78 (1.26-2.53) for 11+ cigarettes/day (p for trend< 0.001). Conclusions: Our preliminary results have shown that tobacco exposure in adolescence were associated with higher risk of NPC in a high-risk area. Further analysis will be conducted after case (target=800) and control (target=1900) recruitment is completed.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://isptid.globalink.org/journal/index.html-
dc.relation.ispartofTobacco Induced Diseases-
dc.relation.ispartofWorld Conference on Tobacco or Health (WCTOH)-
dc.rightsTobacco Induced Diseases. Copyright © BioMed Central Ltd.-
dc.titleTobacco exposure in adolescence and the risk of nasopharyngeal carcinoma: preliminary results from a multi-center case-control study in Hong Kong, China-
dc.typeConference_Paper-
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hk-
dc.identifier.authorityLam, TH=rp00326-
dc.identifier.doi10.18332/tid/84207-
dc.identifier.hkuros285168-
dc.identifier.volume16-
dc.identifier.issuesuppl. 1-
dc.identifier.spage312, abstract no. A818-
dc.identifier.epage312, abstract no. A818-
dc.identifier.isiWOS:000431841800819-
dc.publisher.placeUnited Kingdom-
dc.customcontrol.immutablecsl 180525-

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