File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Regulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study

TitleRegulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study
Authors
Issue Date2017
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/
Citation
Evidence-Based Complementary and Alternative Medicine, 2017, v. 2017, p. 1-13 How to Cite?
AbstractAim. To investigate the relationship between the effects of electroacupuncture/moxibustion and the balance of Th17/Treg in treating ulcerative colitis (UC) and to preliminary compare the effects of the above two methods. Methods. DSS-induced UC mice were treated by electroacupuncture and moxibustion. Disease activity index (DAI) was scored; intestinal pathological structure and ultrastructure were observed. The levels of IL-2, IL-6, IL-10, IL-17A, IL-17F, and TGF-β in plasma were measured by ELISA. The percentages of Treg and Th17 in spleen lymphocytes were analyzed by flow cytometry. Also, the expressions of TLR2, TLR4, RORγt, and FOXP3 in the distal colon were detected by immunohistochemistry or western blot. Results. Both electroacupuncture and moxibustion can relieve UC. These effects are further supported by ELISA results. In addition, the ratio of Treg and Th17 in spleen lymphocytes and the expression of TLR2 and TLR4 are significantly improved. Also, the expression of RORγt and FOXP3 in distal colon were improved. Besides, the effect of moxibustion is better than that of electroacupuncture on TLR2, TLR4, and FOXP3 expression (). Conclusion. Both electroacupuncture and moxibustion may ameliorate UC by regulating the balance of Th17/Treg. Whether moxibustion has better efficacy than electroacupuncture needs further study.
Persistent Identifierhttp://hdl.handle.net/10722/252717
ISSN
2017 Impact Factor: 2.064
2015 SCImago Journal Rankings: 0.615

 

DC FieldValueLanguage
dc.contributor.authorSun, J-
dc.contributor.authorZhang, H-
dc.contributor.authorWang, C-
dc.contributor.authorYang, M-
dc.contributor.authorChang, S-
dc.contributor.authorGeng, Y-
dc.contributor.authorYang, H-
dc.contributor.authorZhuang, Z-
dc.contributor.authorWang, X-
dc.contributor.authorXie, L-
dc.contributor.authorHuang, B-
dc.contributor.authorZhao, N-
dc.contributor.authorZhou, W-
dc.contributor.authorCheng, X-
dc.contributor.authorCai, B-
dc.contributor.authorWu, Q-
dc.contributor.authorYu, SG-
dc.date.accessioned2018-05-02T04:30:48Z-
dc.date.available2018-05-02T04:30:48Z-
dc.date.issued2017-
dc.identifier.citationEvidence-Based Complementary and Alternative Medicine, 2017, v. 2017, p. 1-13-
dc.identifier.issn1741-427X-
dc.identifier.urihttp://hdl.handle.net/10722/252717-
dc.description.abstractAim. To investigate the relationship between the effects of electroacupuncture/moxibustion and the balance of Th17/Treg in treating ulcerative colitis (UC) and to preliminary compare the effects of the above two methods. Methods. DSS-induced UC mice were treated by electroacupuncture and moxibustion. Disease activity index (DAI) was scored; intestinal pathological structure and ultrastructure were observed. The levels of IL-2, IL-6, IL-10, IL-17A, IL-17F, and TGF-β in plasma were measured by ELISA. The percentages of Treg and Th17 in spleen lymphocytes were analyzed by flow cytometry. Also, the expressions of TLR2, TLR4, RORγt, and FOXP3 in the distal colon were detected by immunohistochemistry or western blot. Results. Both electroacupuncture and moxibustion can relieve UC. These effects are further supported by ELISA results. In addition, the ratio of Treg and Th17 in spleen lymphocytes and the expression of TLR2 and TLR4 are significantly improved. Also, the expression of RORγt and FOXP3 in distal colon were improved. Besides, the effect of moxibustion is better than that of electroacupuncture on TLR2, TLR4, and FOXP3 expression (). Conclusion. Both electroacupuncture and moxibustion may ameliorate UC by regulating the balance of Th17/Treg. Whether moxibustion has better efficacy than electroacupuncture needs further study.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/-
dc.relation.ispartofEvidence-Based Complementary and Alternative Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleRegulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study-
dc.typeArticle-
dc.identifier.emailYang, M: mxyang@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2017/7296353-
dc.identifier.hkuros284935-
dc.identifier.volume2017-
dc.identifier.spage1-
dc.identifier.epage13-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats