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Article: Estimating The Magnitude Of Trastuzumab Effects Within Patient Subgroups In The Hera Trial

TitleEstimating The Magnitude Of Trastuzumab Effects Within Patient Subgroups In The Hera Trial
Authors
Issue Date2008
Citation
Annals of Oncology, 2008, v. 19, p. 1090-1096 How to Cite?
AbstractBACKGROUND: Trastuzumab (Herceptin(R)) improves disease-free survival (DFS) and overall survival for patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer. We aimed to assess the magnitude of its clinical benefit for subpopulations defined by nodal and steroid hormone receptor status using data from the Herceptin Adjuvant (HERA) study. PATIENTS AND METHODS: HERA is an international multicenter randomized trial comparing 1 or 2 years of trastuzumab treatment with observation after standard chemotherapy in women with HER2-positive breast cancer. In total, 1703 women randomized to 1-year trastuzumab and 1698 women randomized to observation were included in these analyses. Median follow-up was 23.5 months. The primary endpoint was DFS. RESULTS: The overall hazard ratio (HR) for trastuzumab versus observation was 0.64 [95% confidence interval (CI) 0.54-0.76; P < 0.0001], ranging from 0.46 to 0.82 for subgroups. Estimated improvement in 3-year DFS in subgroups ranged from +11.3% to +0.6%. Patients with the best prognosis (those with node-negative disease and tumors 1.1-2.0 cm) had benefit similar to the overall cohort (HR 0.53, 95% CI 0.26-1.07; 3-year DFS improvement +4.6%, 95% CI -4.0% to 13.2%). CONCLUSIONS: Adjuvant trastuzumab therapy reduces the risk of relapse similarly across subgroups defined by nodal status and steroid hormone receptor status, even those at relatively low risk for relapse.
Persistent Identifierhttp://hdl.handle.net/10722/251812
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorUntch, M-
dc.contributor.authorGelber, RD-
dc.contributor.authorJackisch, C-
dc.contributor.authorProcter, M-
dc.contributor.authorBaselga, J-
dc.contributor.authorBell, R-
dc.contributor.authorCameron, D-
dc.contributor.authorBari, M-
dc.contributor.authorSmith, I-
dc.contributor.authorLeyland-Jones, B-
dc.contributor.authorde Azambuja, E-
dc.contributor.authorWermuth, P-
dc.contributor.authorKhasanov, R-
dc.contributor.authorFeng-yi, F-
dc.contributor.authorConstantin, C-
dc.contributor.authorMayordomo, JI-
dc.contributor.authorSu, CH-
dc.contributor.authorYu, SY-
dc.contributor.authorLluch, A-
dc.contributor.authorSenkus-Konefka, E-
dc.contributor.authorPrice, C-
dc.contributor.authorHaslbauer, F-
dc.contributor.authorSahui, TS-
dc.contributor.authorSrimuninnimit, V-
dc.contributor.authorColleoni, M-
dc.contributor.authorCoates, AS-
dc.contributor.authorPiccart-Gebhart, MJ-
dc.contributor.authorGoldhirsch, A-
dc.contributor.authorKwong, A-
dc.date.accessioned2018-03-19T07:01:39Z-
dc.date.available2018-03-19T07:01:39Z-
dc.date.issued2008-
dc.identifier.citationAnnals of Oncology, 2008, v. 19, p. 1090-1096-
dc.identifier.urihttp://hdl.handle.net/10722/251812-
dc.description.abstractBACKGROUND: Trastuzumab (Herceptin(R)) improves disease-free survival (DFS) and overall survival for patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer. We aimed to assess the magnitude of its clinical benefit for subpopulations defined by nodal and steroid hormone receptor status using data from the Herceptin Adjuvant (HERA) study. PATIENTS AND METHODS: HERA is an international multicenter randomized trial comparing 1 or 2 years of trastuzumab treatment with observation after standard chemotherapy in women with HER2-positive breast cancer. In total, 1703 women randomized to 1-year trastuzumab and 1698 women randomized to observation were included in these analyses. Median follow-up was 23.5 months. The primary endpoint was DFS. RESULTS: The overall hazard ratio (HR) for trastuzumab versus observation was 0.64 [95% confidence interval (CI) 0.54-0.76; P < 0.0001], ranging from 0.46 to 0.82 for subgroups. Estimated improvement in 3-year DFS in subgroups ranged from +11.3% to +0.6%. Patients with the best prognosis (those with node-negative disease and tumors 1.1-2.0 cm) had benefit similar to the overall cohort (HR 0.53, 95% CI 0.26-1.07; 3-year DFS improvement +4.6%, 95% CI -4.0% to 13.2%). CONCLUSIONS: Adjuvant trastuzumab therapy reduces the risk of relapse similarly across subgroups defined by nodal status and steroid hormone receptor status, even those at relatively low risk for relapse.-
dc.languageeng-
dc.relation.ispartofAnnals of Oncology-
dc.titleEstimating The Magnitude Of Trastuzumab Effects Within Patient Subgroups In The Hera Trial-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.identifier.doi10.1093/annonc/mdn005-
dc.identifier.hkuros284566-
dc.identifier.volume19-
dc.identifier.spage1090-
dc.identifier.epage1096-
dc.identifier.isiWOS:000256268100009-

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