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Article: Mammary Phyllodes Tumour: A 15-year Multicentre Clinical Review

TitleMammary Phyllodes Tumour: A 15-year Multicentre Clinical Review
Authors
Issue Date2018
PublisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal of Clinical Pathology, 2018, v. 71 n. 6, p. 493-497 How to Cite?
AbstractAIMS: Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis. METHODS: A 15-year retrospective review from a multicentre database in Hong Kong was performed. RESULTS: Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12-86 years). 281 (59.9%) PTs were benign, 124 (26.4%) were borderline and 64 (13.6%) were malignant.About half of all PTs (239, 51.5%) were between 2 and 5 cm while another 186 (40.1%) were >5 cm in size. Most PT (84.6%) were radiologically benign.Breast-conserving surgery (BCS) was feasible in 384 (82%) patients, whereas 84 (18%) patients had mastectomy. Multivariate analysis found that positive surgical margin (P<0.001) and BCS (P<0.001) were the only significant risk factors for local recurrence, while large tumour size (P=0.008) and malignant PT histotype (P<0.001) were the only significant risk factors for metastasis.Long-term prognosis of benign and borderline PT was excellent. After median follow-up interval of 85 months (range 12-180 months), the disease-specific survival of benign, borderline and malignant PT were 99.6%, 100% and 90.6%, respectively. CONCLUSIONS: Local recurrence of PTs occurs irrespective of the tumour grade. Surgical margin is the only amendable factor to reduce the chance of recurrence.
Persistent Identifierhttp://hdl.handle.net/10722/251811
ISSN
2017 Impact Factor: 2.894
2015 SCImago Journal Rankings: 1.260
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCo, THM-
dc.contributor.authorChen, C-
dc.contributor.authorTsang, JY-
dc.contributor.authorTse, G-
dc.contributor.authorKwong, A-
dc.date.accessioned2018-03-19T07:01:38Z-
dc.date.available2018-03-19T07:01:38Z-
dc.date.issued2018-
dc.identifier.citationJournal of Clinical Pathology, 2018, v. 71 n. 6, p. 493-497-
dc.identifier.issn0021-9746-
dc.identifier.urihttp://hdl.handle.net/10722/251811-
dc.description.abstractAIMS: Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis. METHODS: A 15-year retrospective review from a multicentre database in Hong Kong was performed. RESULTS: Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12-86 years). 281 (59.9%) PTs were benign, 124 (26.4%) were borderline and 64 (13.6%) were malignant.About half of all PTs (239, 51.5%) were between 2 and 5 cm while another 186 (40.1%) were >5 cm in size. Most PT (84.6%) were radiologically benign.Breast-conserving surgery (BCS) was feasible in 384 (82%) patients, whereas 84 (18%) patients had mastectomy. Multivariate analysis found that positive surgical margin (P<0.001) and BCS (P<0.001) were the only significant risk factors for local recurrence, while large tumour size (P=0.008) and malignant PT histotype (P<0.001) were the only significant risk factors for metastasis.Long-term prognosis of benign and borderline PT was excellent. After median follow-up interval of 85 months (range 12-180 months), the disease-specific survival of benign, borderline and malignant PT were 99.6%, 100% and 90.6%, respectively. CONCLUSIONS: Local recurrence of PTs occurs irrespective of the tumour grade. Surgical margin is the only amendable factor to reduce the chance of recurrence.-
dc.languageeng-
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/-
dc.relation.ispartofJournal of Clinical Pathology-
dc.rightsJournal of Clinical Pathology. Copyright © BMJ Publishing Group.-
dc.titleMammary Phyllodes Tumour: A 15-year Multicentre Clinical Review-
dc.typeArticle-
dc.identifier.emailCo, THM: mcth@hku.hk-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityCo, THM=rp02101-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/jclinpath-2017-204827-
dc.identifier.pmid29146885-
dc.identifier.scopuseid_2-s2.0-85047920194-
dc.identifier.hkuros284564-
dc.identifier.volume71-
dc.identifier.issue6-
dc.identifier.spage493-
dc.identifier.epage497-
dc.identifier.isiWOS:000433240800003-
dc.publisher.placeUnited Kingdom-

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