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Article: A translational study on looming-evoked defensive response and the underlying subcortical pathway in autism

TitleA translational study on looming-evoked defensive response and the underlying subcortical pathway in autism
Authors
Issue Date2017
PublisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2017, v. 7, p. Article no.14755 How to Cite?
AbstractRapidly approaching objects indicating threats can induce defensive response through activating a subcortical pathway comprising superior colliculus (SC), lateral posterior nucleus (LP), and basolateral amygdala (BLA). Abnormal defensive response has been reported in autism, and impaired synaptic connections could be the underlying mechanism. Whether the SC-LP-BLA pathway processes looming stimuli abnormally in autism is not clear. Here, we found that looming-evoked defensive response is impaired in a subgroup of the valproic acid (VPA) mouse model of autism. By combining the conventional neurotracer and transneuronal rabies virus tracing techniques, we demonstrated that synaptic connections in the SC-LP-BLA pathway were abnormal in VPA mice whose looming-evoked defensive responses were absent. Importantly, we further translated the finding to children with autism and observed that they did not present looming-evoked defensive response. Furthermore, the findings of the DTI with the probabilistic tractography showed that the structural connections of SC-pulvinar-amygdala in autism children were weak. The pulvinar is parallel to the LP in a mouse. Because looming-evoked defensive response is innate in humans and emerges much earlier than do social and language functions, the absence of defensive response could be an earlier sign of autism in children.
Persistent Identifierhttp://hdl.handle.net/10722/251755
ISSN
2017 Impact Factor: 4.122
2015 SCImago Journal Rankings: 2.073
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHu, Y-
dc.contributor.authorChen, Z-
dc.contributor.authorHuang, L-
dc.contributor.authorXi, Y-
dc.contributor.authorLi, B-
dc.contributor.authorWang, H-
dc.contributor.authorYan, J-
dc.contributor.authorLee, TMC-
dc.contributor.authorTao, Q-
dc.contributor.authorSo, KF-
dc.contributor.authorRen, C-
dc.date.accessioned2018-03-19T07:00:40Z-
dc.date.available2018-03-19T07:00:40Z-
dc.date.issued2017-
dc.identifier.citationScientific Reports, 2017, v. 7, p. Article no.14755-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/251755-
dc.description.abstractRapidly approaching objects indicating threats can induce defensive response through activating a subcortical pathway comprising superior colliculus (SC), lateral posterior nucleus (LP), and basolateral amygdala (BLA). Abnormal defensive response has been reported in autism, and impaired synaptic connections could be the underlying mechanism. Whether the SC-LP-BLA pathway processes looming stimuli abnormally in autism is not clear. Here, we found that looming-evoked defensive response is impaired in a subgroup of the valproic acid (VPA) mouse model of autism. By combining the conventional neurotracer and transneuronal rabies virus tracing techniques, we demonstrated that synaptic connections in the SC-LP-BLA pathway were abnormal in VPA mice whose looming-evoked defensive responses were absent. Importantly, we further translated the finding to children with autism and observed that they did not present looming-evoked defensive response. Furthermore, the findings of the DTI with the probabilistic tractography showed that the structural connections of SC-pulvinar-amygdala in autism children were weak. The pulvinar is parallel to the LP in a mouse. Because looming-evoked defensive response is innate in humans and emerges much earlier than do social and language functions, the absence of defensive response could be an earlier sign of autism in children.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleA translational study on looming-evoked defensive response and the underlying subcortical pathway in autism-
dc.typeArticle-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authorityLee, TMC=rp00564-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-017-15349-x-
dc.identifier.hkuros284466-
dc.identifier.volume7-
dc.identifier.spageArticle no.14755-
dc.identifier.epageArticle no.14755-
dc.identifier.isiWOS:000414569100045-
dc.publisher.placeUnited Kingdom-

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