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Article: Influenza Vaccine Effectiveness Against Influenza A(H3N2) Hospitalizations in Children in Hong Kong in a Prolonged Season, 2016/2017

TitleInfluenza Vaccine Effectiveness Against Influenza A(H3N2) Hospitalizations in Children in Hong Kong in a Prolonged Season, 2016/2017
Authors
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/
Citation
Journal of Infectious Diseases, 2018, v. 217 n. 9, p. 1365-1371 How to Cite?
AbstractBackground: Influenza A(H3N2) viruses circulated for 12 consecutive months in Hong Kong in 2016-2017, peaking in late June and July 2017. The objective of our study was to estimate the effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong. Methods: We conducted a test-negative study between September 1 2016 and August 31 2017, enrolling children 6 months to 17 years of age hospitalized for an acute respiratory infection. Influenza was diagnosed by PCR on nasopharyngeal aspirates. Results: We enrolled 5514 children, including 3608 children between 6 months to 2 years, 1600 children 3-5 years, and 1206 children 6-17 years of age. Influenza-associated hospitalizations occurred throughout the study year but time of vaccination of these children was also wide-spread, from September 2016 to May 2017. Influenza vaccine effectiveness (VE) was 39.7% (95% CI: 14.7, 57.3%) against laboratory-confirmed influenza A(H3N2). In analyses stratified by time since vaccination, the VE against influenza A(H3N2) was 52.8% (17.1%, 73.2%) within 3 months of vaccination, and 31.2% (-6.6%, 55.6%) 4-6 months after vaccination. Conclusions: Influenza vaccination was effective in preventing hospitalizations in children in Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/251732
ISSN
2017 Impact Factor: 5.186
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChiu, SSS-
dc.contributor.authorKwan, YW-
dc.contributor.authorFeng, S-
dc.contributor.authorWong, JSC-
dc.contributor.authorLeung, CW-
dc.contributor.authorChan, LY-
dc.contributor.authorChan, KH-
dc.contributor.authorNg, TK-
dc.contributor.authorTo, WK-
dc.contributor.authorCowling, BJ-
dc.contributor.authorPeiris, JSM-
dc.date.accessioned2018-03-19T07:00:13Z-
dc.date.available2018-03-19T07:00:13Z-
dc.date.issued2018-
dc.identifier.citationJournal of Infectious Diseases, 2018, v. 217 n. 9, p. 1365-1371-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/251732-
dc.description.abstractBackground: Influenza A(H3N2) viruses circulated for 12 consecutive months in Hong Kong in 2016-2017, peaking in late June and July 2017. The objective of our study was to estimate the effectiveness of influenza vaccination in preventing hospitalizations in children in Hong Kong. Methods: We conducted a test-negative study between September 1 2016 and August 31 2017, enrolling children 6 months to 17 years of age hospitalized for an acute respiratory infection. Influenza was diagnosed by PCR on nasopharyngeal aspirates. Results: We enrolled 5514 children, including 3608 children between 6 months to 2 years, 1600 children 3-5 years, and 1206 children 6-17 years of age. Influenza-associated hospitalizations occurred throughout the study year but time of vaccination of these children was also wide-spread, from September 2016 to May 2017. Influenza vaccine effectiveness (VE) was 39.7% (95% CI: 14.7, 57.3%) against laboratory-confirmed influenza A(H3N2). In analyses stratified by time since vaccination, the VE against influenza A(H3N2) was 52.8% (17.1%, 73.2%) within 3 months of vaccination, and 31.2% (-6.6%, 55.6%) 4-6 months after vaccination. Conclusions: Influenza vaccination was effective in preventing hospitalizations in children in Hong Kong.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/-
dc.relation.ispartofJournal of Infectious Diseases-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version Journal of Infectious Diseases, 2018, v. 217 n. 9, p. 1365-1371 is available online at: https://academic.oup.com/jid/article-abstract/217/9/1365/4810661?redirectedFrom=fulltext-
dc.titleInfluenza Vaccine Effectiveness Against Influenza A(H3N2) Hospitalizations in Children in Hong Kong in a Prolonged Season, 2016/2017-
dc.typeArticle-
dc.identifier.emailChiu, SSS: ssschiu@hku.hk-
dc.identifier.emailKwan, YW: ywmkwan@hku.hk-
dc.identifier.emailLeung, CW: ccwleung@hkucc.hku.hk-
dc.identifier.emailChan, LY: laiyin@hkucc.hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityChiu, SSS=rp00421-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepostprint-
dc.identifier.doi10.1093/infdis/jiy027-
dc.identifier.hkuros284396-
dc.identifier.volume217-
dc.identifier.issue9-
dc.identifier.spage1365-
dc.identifier.epage1371-
dc.identifier.isiWOS:000430729300005-
dc.publisher.placeUnited States-

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