Links for fulltext
     (May Require Subscription)
Supplementary

Article: Immune responses to twice-annual influenza vaccination in older adults in Hong Kong

TitleImmune responses to twice-annual influenza vaccination in older adults in Hong Kong
Authors
Keywordsimmunity
influenza
public health
vaccination
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2018, v. 66 n. 6, p. 904-912 How to Cite?
AbstractBACKGROUND: Many health authorities recommend influenza vaccination of older adults to reduce disease burden. We hypothesized that in tropical and subtropical areas with more prolonged influenza seasons, twice-annual influenza vaccination might provide older adults with improved immunity against influenza. METHODS: In 2014/15, Hong Kong experienced a substantial A(H3N2) winter epidemic with a mismatched vaccine. Local authorities procured and administered to older adults the 2015 southern hemisphere influenza vaccine which included an updated and matching A/Switzerland/9715293/2013(H3N2) strain. We compared immune parameters in pre- and post-vaccination sera from older adults ≥75 years of age who received one versus two influenza vaccines per year. RESULTS: We enrolled 978 older adults with 470 vaccinations for summer 2015 and 827 vaccinations for winter 2015/16. Recipients of southern hemisphere vaccination had higher geometric mean titers (GMTs) by the hemagglutination inhibition assay against all three vaccine strains. When receiving influenza vaccination for the subsequent winter, the southern hemisphere vaccine recipients had higher pre-vaccination GMTs but lower post-vaccination GMTs, compared to those who had not received the southern hemisphere vaccine. Furthermore, cellular immunity was impacted by bi-annual vaccination, with reduced influenza-specific CD4 T cell responses in the second season of vaccination. CONCLUSIONS: We observed some reductions in immune responses in the twice-annual vaccination group compared to once-annual vaccination group, in the context of unchanging vaccine strains, while protection was likely to have been improved during the summer and autumn for the twice-annual vaccination group due to the continued circulation of the A/Switzerland/9715293/2013(H3N2) virus.
Persistent Identifierhttp://hdl.handle.net/10722/250155
ISSN
2017 Impact Factor: 9.117
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, YH-
dc.contributor.authorDoak, SA-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorWong, JHF-
dc.contributor.authorFang, J-
dc.contributor.authorNg, TW-
dc.contributor.authorKwong, ASK-
dc.contributor.authorTsui, WWS-
dc.contributor.authorIp, DKM-
dc.contributor.authorPoon, LML-
dc.contributor.authorChau, CKV-
dc.contributor.authorBarr, IG-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2017-12-20T09:21:33Z-
dc.date.available2017-12-20T09:21:33Z-
dc.date.issued2018-
dc.identifier.citationClinical Infectious Diseases, 2018, v. 66 n. 6, p. 904-912-
dc.identifier.issn1058-4838-
dc.identifier.urihttp://hdl.handle.net/10722/250155-
dc.description.abstractBACKGROUND: Many health authorities recommend influenza vaccination of older adults to reduce disease burden. We hypothesized that in tropical and subtropical areas with more prolonged influenza seasons, twice-annual influenza vaccination might provide older adults with improved immunity against influenza. METHODS: In 2014/15, Hong Kong experienced a substantial A(H3N2) winter epidemic with a mismatched vaccine. Local authorities procured and administered to older adults the 2015 southern hemisphere influenza vaccine which included an updated and matching A/Switzerland/9715293/2013(H3N2) strain. We compared immune parameters in pre- and post-vaccination sera from older adults ≥75 years of age who received one versus two influenza vaccines per year. RESULTS: We enrolled 978 older adults with 470 vaccinations for summer 2015 and 827 vaccinations for winter 2015/16. Recipients of southern hemisphere vaccination had higher geometric mean titers (GMTs) by the hemagglutination inhibition assay against all three vaccine strains. When receiving influenza vaccination for the subsequent winter, the southern hemisphere vaccine recipients had higher pre-vaccination GMTs but lower post-vaccination GMTs, compared to those who had not received the southern hemisphere vaccine. Furthermore, cellular immunity was impacted by bi-annual vaccination, with reduced influenza-specific CD4 T cell responses in the second season of vaccination. CONCLUSIONS: We observed some reductions in immune responses in the twice-annual vaccination group compared to once-annual vaccination group, in the context of unchanging vaccine strains, while protection was likely to have been improved during the summer and autumn for the twice-annual vaccination group due to the continued circulation of the A/Switzerland/9715293/2013(H3N2) virus.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/-
dc.relation.ispartofClinical Infectious Diseases-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The definitive publisher-authenticated version Clinical Infectious Diseases, 2018, v. 66 n. 6, p. 904-912 is available online at: https://academic.oup.com/cid/article-abstract/66/6/904/4560802?redirectedFrom=fulltext-
dc.subjectimmunity-
dc.subjectinfluenza-
dc.subjectpublic health-
dc.subjectvaccination-
dc.titleImmune responses to twice-annual influenza vaccination in older adults in Hong Kong-
dc.typeArticle-
dc.identifier.emailTam, YH: yhtam@hku.hk-
dc.identifier.emailDoak, SA: sophiev@hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailWong, JHF: hfjwong@hku.hk-
dc.identifier.emailFang, J: vickyf@hku.hk-
dc.identifier.emailIp, DKM: dkmip@hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityTam, YH=rp01881-
dc.identifier.authorityDoak, SA=rp02141-
dc.identifier.authorityIp, DKM=rp00256-
dc.identifier.authorityPoon, LML=rp00484-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepostprint-
dc.identifier.doi10.1093/cid/cix900-
dc.identifier.pmid29069368-
dc.identifier.scopuseid_2-s2.0-85040837096-
dc.identifier.hkuros283476-
dc.identifier.volume66-
dc.identifier.issue6-
dc.identifier.spage904-
dc.identifier.epage912-
dc.identifier.isiWOS:000426819800012-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats