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Article: Fetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis

TitleFetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis
Authors
KeywordsDiabetes mellitus
Fetuin-A
Meta-analysis
Systematic review
Issue Date2018
PublisherSpringer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=18
Citation
Acta Diabetologica, 2018, v. 55 n. 1, p. 87-98 How to Cite?
AbstractAims: Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. Methods: A systematic search of studies from the MEDLINE, EMBASE, Pubmed and Web of Science using fetuin-A, diabetes and various synonyms was conducted up to June 5, 2017. Relevant studies were extracted by two reviewers independently. The quality of studies was assessed using Newcastle–Ottawa scales. Overall estimates were pooled using fixed effect with inverse variance meta-analysis. Subgroup analyses by gender, study population, techniques of assessing fetuin-A, diabetes ascertainment methods, follow-up duration and measures of association were conducted. Results: Seven studies comprising a total of 11,497 individuals and 2176 cases of T2DM were included in the systematic review and meta-analysis. Overall, one SD increment of fetuin-A level was associated with a 23% greater risk of incident T2DM (RR: 1.23, 95% CI 1.16–1.31). No significant heterogeneity or publication bias was found. The association was relatively stable across different subgroups. However, the association seemed only evident in women, but not in men. Conclusions: Higher circulating fetuin-A levels were associated with increased risk of T2DM. However, the causality deserved further analysis. © 2017, Springer-Verlag Italia S.r.l.
Persistent Identifierhttp://hdl.handle.net/10722/250007
ISSN
2017 Impact Factor: 3.126
2015 SCImago Journal Rankings: 1.318
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuo, Y-
dc.contributor.authorCao, B-
dc.contributor.authorCai, CY-
dc.contributor.authorCheng, KKY-
dc.contributor.authorCheung, BMY-
dc.date.accessioned2017-12-20T09:19:17Z-
dc.date.available2017-12-20T09:19:17Z-
dc.date.issued2018-
dc.identifier.citationActa Diabetologica, 2018, v. 55 n. 1, p. 87-98-
dc.identifier.issn0940-5429-
dc.identifier.urihttp://hdl.handle.net/10722/250007-
dc.description.abstractAims: Fetuin-A has been linked to insulin resistance and obesity. Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. We aimed to investigate the prospective association of fetuin-A and the risk of T2DM in a systematic review and meta-analysis. Methods: A systematic search of studies from the MEDLINE, EMBASE, Pubmed and Web of Science using fetuin-A, diabetes and various synonyms was conducted up to June 5, 2017. Relevant studies were extracted by two reviewers independently. The quality of studies was assessed using Newcastle–Ottawa scales. Overall estimates were pooled using fixed effect with inverse variance meta-analysis. Subgroup analyses by gender, study population, techniques of assessing fetuin-A, diabetes ascertainment methods, follow-up duration and measures of association were conducted. Results: Seven studies comprising a total of 11,497 individuals and 2176 cases of T2DM were included in the systematic review and meta-analysis. Overall, one SD increment of fetuin-A level was associated with a 23% greater risk of incident T2DM (RR: 1.23, 95% CI 1.16–1.31). No significant heterogeneity or publication bias was found. The association was relatively stable across different subgroups. However, the association seemed only evident in women, but not in men. Conclusions: Higher circulating fetuin-A levels were associated with increased risk of T2DM. However, the causality deserved further analysis. © 2017, Springer-Verlag Italia S.r.l.-
dc.languageeng-
dc.publisherSpringer-Verlag Italia Srl. The Journal's web site is located at http://www.springer.it/libri_libro.asp?id=18-
dc.relation.ispartofActa Diabetologica-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/[insert DOI]-
dc.subjectDiabetes mellitus-
dc.subjectFetuin-A-
dc.subjectMeta-analysis-
dc.subjectSystematic review-
dc.titleFetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis-
dc.typeArticle-
dc.identifier.emailGuo, Y: viviguo@hku.hk-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.authorityCheung, BMY=rp01321-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00592-017-1068-9-
dc.identifier.pmid29127490-
dc.identifier.scopuseid_2-s2.0-85033445435-
dc.identifier.hkuros283767-
dc.identifier.volume55-
dc.identifier.issue1-
dc.identifier.spage87-
dc.identifier.epage98-
dc.identifier.isiWOS:000424018600010-
dc.publisher.placeItaly-

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