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Article: International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma

TitleInternational guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma
Authors
KeywordsNasopharyngeal carcinoma
Clinical target volume (CTV)
Gross target volume (GTV)
Guideline
Delineation
Issue Date2018
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radonc
Citation
Radiotherapy & Oncology, 2018, v. 126 n. 1, p. 25-36 How to Cite?
AbstractPurpose: Target delineation in nasopharyngeal carcinoma (NPC) often proves challenging because of the notoriously narrow therapeutic margin. High doses are needed to achieve optimal levels of tumour control, and dosimetric inadequacy remains one of the most important independent factors affecting treatment outcome. Method: A review of the available literature addressing the natural behaviour of NPC and correlation between clinical and pathological aspects of the disease was conducted. Existing international guidelines as well as published protocols specified by clinical trials on contouring of clinical target volumes (CTV) were compared. This information was then summarized into a preliminary draft guideline which was then circulated to international experts in the field for exchange of opinions and subsequent voting on areas with the greatest controversies. Results: Common areas of uncertainty and variation in practices among experts experienced in radiation therapy for NPC were elucidated. Iterative revisions were made based on extensive discussion and final voting on controversial areas by the expert panel, to formulate the recommendations on contouring of CTV based on optimal geometric expansion and anatomical editing for those structures with substantial risk of microscopic infiltration. Conclusion: Through this comprehensive review of available evidence and best practices at major institutions, as well as interactive exchange of vast experience by international experts, this set of consensus guidelines has been developed to provide a practical reference for appropriate contouring to ensure optimal target coverage. However, the final decision on the treatment volumes should be based on full consideration of individual patients’ factors and facilities of an individual centre (including the quality of imaging methods and the precision of treatment delivery). © 2017 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/249992
ISSN
2017 Impact Factor: 4.942
2015 SCImago Journal Rankings: 2.654
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, WMA-
dc.contributor.authorNg, WT-
dc.contributor.authorPan, JJ-
dc.contributor.authorPoh, SS-
dc.contributor.authorAhn, YC-
dc.contributor.authorAlHussain, H-
dc.contributor.authorCorry, J-
dc.contributor.authorGrau, C-
dc.contributor.authorGrégoire, V-
dc.contributor.authorHarrington, KJ-
dc.contributor.authorHu, CS-
dc.contributor.authorKwong, DLW-
dc.contributor.authorLangendijk, JA-
dc.contributor.authorLe, QT-
dc.contributor.authorLee, NY-
dc.contributor.authorLin, JC-
dc.contributor.authorLu, TX-
dc.contributor.authorMendenhall, WM-
dc.contributor.authorO'Sullivan, B-
dc.contributor.authorOzyar, E-
dc.contributor.authorPeters, LJ-
dc.contributor.authorRosenthal, DI-
dc.contributor.authorSoong, YL-
dc.contributor.authorTao, YG-
dc.contributor.authorYom, SS-
dc.contributor.authorWee, JT-
dc.date.accessioned2017-12-20T09:19:05Z-
dc.date.available2017-12-20T09:19:05Z-
dc.date.issued2018-
dc.identifier.citationRadiotherapy & Oncology, 2018, v. 126 n. 1, p. 25-36-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/249992-
dc.description.abstractPurpose: Target delineation in nasopharyngeal carcinoma (NPC) often proves challenging because of the notoriously narrow therapeutic margin. High doses are needed to achieve optimal levels of tumour control, and dosimetric inadequacy remains one of the most important independent factors affecting treatment outcome. Method: A review of the available literature addressing the natural behaviour of NPC and correlation between clinical and pathological aspects of the disease was conducted. Existing international guidelines as well as published protocols specified by clinical trials on contouring of clinical target volumes (CTV) were compared. This information was then summarized into a preliminary draft guideline which was then circulated to international experts in the field for exchange of opinions and subsequent voting on areas with the greatest controversies. Results: Common areas of uncertainty and variation in practices among experts experienced in radiation therapy for NPC were elucidated. Iterative revisions were made based on extensive discussion and final voting on controversial areas by the expert panel, to formulate the recommendations on contouring of CTV based on optimal geometric expansion and anatomical editing for those structures with substantial risk of microscopic infiltration. Conclusion: Through this comprehensive review of available evidence and best practices at major institutions, as well as interactive exchange of vast experience by international experts, this set of consensus guidelines has been developed to provide a practical reference for appropriate contouring to ensure optimal target coverage. However, the final decision on the treatment volumes should be based on full consideration of individual patients’ factors and facilities of an individual centre (including the quality of imaging methods and the precision of treatment delivery). © 2017 Elsevier B.V.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/radonc-
dc.relation.ispartofRadiotherapy & Oncology-
dc.subjectNasopharyngeal carcinoma-
dc.subjectClinical target volume (CTV)-
dc.subjectGross target volume (GTV)-
dc.subjectGuideline-
dc.subjectDelineation-
dc.titleInternational guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailLee, WMA: awmlee@hkucc.hku.hk-
dc.identifier.emailNg, WT: ngwt1@hkucc.hku.hk-
dc.identifier.emailKwong, DLW: dlwkwong@hku.hk-
dc.identifier.authorityLee, WMA=rp02056-
dc.identifier.authorityKwong, DLW=rp00414-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.radonc.2017.10.032-
dc.identifier.pmid29153464-
dc.identifier.scopuseid_2-s2.0-85033791893-
dc.identifier.hkuros283795-
dc.identifier.volume126-
dc.identifier.issue1-
dc.identifier.spage25-
dc.identifier.epage36-
dc.identifier.isiWOS:000425578100003-
dc.publisher.placeIreland-

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