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Article: Factors affecting patient-reported outcomes after red blood cell transfusion in medical patients

TitleFactors affecting patient-reported outcomes after red blood cell transfusion in medical patients
Authors
Issue Date2018
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1537-2995
Citation
Transfusion, 2018, v. 58 n. 1, p. 158-167 How to Cite?
AbstractBACKGROUND Physical variables like mortality or cardiac events were used to evaluate the requirement of red blood cell (RBC) transfusion. However, patient-reported outcomes (PROs) of blood transfusion recipients were seldom assessed. The health-related quality of life (HRQoL) of patients before and after RBC transfusion was compared in this study. STUDY DESIGN AND METHODS The study period was February to June 2016. Standardized generic and anemia symptom-specific HRQoL instruments were administered to patients receiving RBC transfusion in the medical unit of a single center. The primary outcome was the change in HRQoL scores on Days 1 and 7 posttransfusion from baseline values on the day of transfusion (Day 0). Multiple linear regression analysis was performed to study the effect of transfusion strategy and other factors on PRO. RESULTS The analysis included 99 general medical patients. The median (interquartile range) pretransfusion hemoglobin level was 72 (66-78) g/L. Two or more units of RBCs were prescribed to 45 patients (45%) on Day 0. Functional Assessment of Cancer Therapy-Anemia Subscale improved significantly on Days 1 and 7 by effect sizes of 0.41 and 0.38, respectively (p < 0.001). Regression analysis showed that lower baseline HRQoL scores were associated with better PRO on both Day 1 and Day 7 (p < 0.001). Transfusion trigger and number of RBC units transfused did not affect the change in HRQoL. CONCLUSION Worse pretransfusion HRQoL is a predictor of improvement in PRO after blood transfusion. There is no evidence that a restrictive transfusion or single-unit policy jeopardizes PRO.
Persistent Identifierhttp://hdl.handle.net/10722/249963
ISSN
2017 Impact Factor: 3.423
2015 SCImago Journal Rankings: 1.537
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, LKK-
dc.contributor.authorMak, VWM-
dc.contributor.authorTam, YH-
dc.contributor.authorLee, HKK-
dc.date.accessioned2017-12-20T09:18:42Z-
dc.date.available2017-12-20T09:18:42Z-
dc.date.issued2018-
dc.identifier.citationTransfusion, 2018, v. 58 n. 1, p. 158-167-
dc.identifier.issn0041-1132-
dc.identifier.urihttp://hdl.handle.net/10722/249963-
dc.description.abstractBACKGROUND Physical variables like mortality or cardiac events were used to evaluate the requirement of red blood cell (RBC) transfusion. However, patient-reported outcomes (PROs) of blood transfusion recipients were seldom assessed. The health-related quality of life (HRQoL) of patients before and after RBC transfusion was compared in this study. STUDY DESIGN AND METHODS The study period was February to June 2016. Standardized generic and anemia symptom-specific HRQoL instruments were administered to patients receiving RBC transfusion in the medical unit of a single center. The primary outcome was the change in HRQoL scores on Days 1 and 7 posttransfusion from baseline values on the day of transfusion (Day 0). Multiple linear regression analysis was performed to study the effect of transfusion strategy and other factors on PRO. RESULTS The analysis included 99 general medical patients. The median (interquartile range) pretransfusion hemoglobin level was 72 (66-78) g/L. Two or more units of RBCs were prescribed to 45 patients (45%) on Day 0. Functional Assessment of Cancer Therapy-Anemia Subscale improved significantly on Days 1 and 7 by effect sizes of 0.41 and 0.38, respectively (p < 0.001). Regression analysis showed that lower baseline HRQoL scores were associated with better PRO on both Day 1 and Day 7 (p < 0.001). Transfusion trigger and number of RBC units transfused did not affect the change in HRQoL. CONCLUSION Worse pretransfusion HRQoL is a predictor of improvement in PRO after blood transfusion. There is no evidence that a restrictive transfusion or single-unit policy jeopardizes PRO.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1537-2995-
dc.relation.ispartofTransfusion-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article]. -
dc.titleFactors affecting patient-reported outcomes after red blood cell transfusion in medical patients-
dc.typeArticle-
dc.identifier.emailTam, YH: yhtam@hku.hk-
dc.identifier.authorityTam, YH=rp01881-
dc.identifier.doi10.1111/trf.14397-
dc.identifier.hkuros283475-
dc.identifier.volume58-
dc.identifier.issue1-
dc.identifier.spage158-
dc.identifier.epage167-
dc.identifier.isiWOS:000419507100023-
dc.publisher.placeUnited States-

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