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Article: Understanding the role of PIN1 in hepatocellular carcinoma

TitleUnderstanding the role of PIN1 in hepatocellular carcinoma
Authors
KeywordsPhosphorylation
Hepatocellular carcinoma
PIN1
Isomerization
Hepatocarcinogenesis
Issue Date2016
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal of Gastroenterology, 2016, v. 22 n. 45, p. 9921-9932 How to Cite?
AbstractPIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) in proteins. PIN1 can therefore induce conformational and functional changes of its interacting proteins that are regulated by proline-directed serine/threonine phosphorylation. Through this phosphorylation-dependent prolyl isomerization, PIN1 fine-tunes the functions of key phosphoproteins (e.g., cyclin D1, survivin, β-catenin and x-protein of hepatitis B virus) that are involved in the regulation of cell cycle progression, apoptosis, proliferation and oncogenic transformation. PIN1 has been found to be over-expressed in many cancers, including human hepatocellular carcinoma (HCC). It has been shown previously that overexpression of PIN1 contributes to the development of HCC in-vitro and in xenograft mouse model. In this review, we first discussed the aberrant transcription factor expression, miRNAs dysregulation, PIN1 gene promoter polymorphisms and phosphorylation of PIN1 as potential mechanisms underlying PIN1 overexpression in cancers. Furthermore, we also examined the role of PIN1 in HCC tumourigenesis by reviewing the interactions between PIN1 and various cellular and viral proteins that are involved in β-catenin, NOTCH, and PI3K/Akt/mTOR pathways, apoptosis, angiogenesis and epithelial-mesenchymal transition. Finally, the potential of PIN1 inhibitors as an anti-cancer therapy was explored and discussed.
Persistent Identifierhttp://hdl.handle.net/10722/249659
ISSN
2017 Impact Factor: 3.3
2015 SCImago Journal Rankings: 1.076
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, CW-
dc.contributor.authorLeong, KW-
dc.contributor.authorTse, EWC-
dc.date.accessioned2017-11-21T03:05:15Z-
dc.date.available2017-11-21T03:05:15Z-
dc.date.issued2016-
dc.identifier.citationWorld Journal of Gastroenterology, 2016, v. 22 n. 45, p. 9921-9932-
dc.identifier.issn1007-9327-
dc.identifier.urihttp://hdl.handle.net/10722/249659-
dc.description.abstractPIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) in proteins. PIN1 can therefore induce conformational and functional changes of its interacting proteins that are regulated by proline-directed serine/threonine phosphorylation. Through this phosphorylation-dependent prolyl isomerization, PIN1 fine-tunes the functions of key phosphoproteins (e.g., cyclin D1, survivin, β-catenin and x-protein of hepatitis B virus) that are involved in the regulation of cell cycle progression, apoptosis, proliferation and oncogenic transformation. PIN1 has been found to be over-expressed in many cancers, including human hepatocellular carcinoma (HCC). It has been shown previously that overexpression of PIN1 contributes to the development of HCC in-vitro and in xenograft mouse model. In this review, we first discussed the aberrant transcription factor expression, miRNAs dysregulation, PIN1 gene promoter polymorphisms and phosphorylation of PIN1 as potential mechanisms underlying PIN1 overexpression in cancers. Furthermore, we also examined the role of PIN1 in HCC tumourigenesis by reviewing the interactions between PIN1 and various cellular and viral proteins that are involved in β-catenin, NOTCH, and PI3K/Akt/mTOR pathways, apoptosis, angiogenesis and epithelial-mesenchymal transition. Finally, the potential of PIN1 inhibitors as an anti-cancer therapy was explored and discussed.-
dc.languageeng-
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm-
dc.relation.ispartofWorld Journal of Gastroenterology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectPhosphorylation-
dc.subjectHepatocellular carcinoma-
dc.subjectPIN1-
dc.subjectIsomerization-
dc.subjectHepatocarcinogenesis-
dc.titleUnderstanding the role of PIN1 in hepatocellular carcinoma-
dc.typeArticle-
dc.identifier.emailCheng, CW: timwai@hku.hk-
dc.identifier.emailLeong, KW: ckwleong@HKUCC-COM.hku.hk-
dc.identifier.emailTse, EWC: ewctse@hku.hk-
dc.identifier.authorityTse, EWC=rp00471-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3748/wjg.v22.i45.9921-
dc.identifier.pmcidPMC5143759-
dc.identifier.hkuros282578-
dc.identifier.volume22-
dc.identifier.issue45-
dc.identifier.spage9921-
dc.identifier.epage9932-
dc.identifier.isiWOS:000389848200005-
dc.publisher.placeUnited States-

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