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Article: CR2Cancer: a database for chromatin regulators in human cancer

TitleCR2Cancer: a database for chromatin regulators in human cancer
Authors
Issue Date2018
PublisherOxford University Press (OUP): Policy C - Option B. The Journal's web site is located at http://nar.oxfordjournals.org/
Citation
Nucleic Acids Research, 2018, v. 46 n. D1, p. D918-D924 How to Cite?
AbstractIdentification of Master Regulators (MRs) during cancer development contributes greatly to the design of novel targeted therapy. However, it is challenging to trace the MR that regulate the gene signature (e.g. differentially expressed genes) derived from a limited number of transcriptome profiles. The main reason is that the targets (collectively termed as regulon) of MRs in cancer type-specific context is not available for enrichment analysis in the signature. To this aim, we generated the regulon of MRs using high throughput omics data from The Cancer Genome Atlas (TCGA), and developed a web server MR4Cancer, which can prioritize MRs driving phenotypic differentiation of interest in 26 cancer types. Based on the input gene list or expression profiles, it outputs six groups of ranked MRs, including transcription regulators, miRNAs, recurrently mutated genes, kinases, phosphatases, and hubs from protein-protein interaction network. Simultaneously, Gene Ontology and canonical pathway analyses are also conducted to further elucidate the function of MR candidates. Moreover, our tool presents dynamic network visualization for MR-target relations, and users can interactively customize it as high quality figures for their publications. We expect this user-friendly and powerful web application will provide researchers new insights into carcinogenesis and therapeutic intervention.
Persistent Identifierhttp://hdl.handle.net/10722/249561
ISSN
2017 Impact Factor: 11.561
2015 SCImago Journal Rankings: 7.458
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRU, B-
dc.contributor.authorSUN, J-
dc.contributor.authorTONG, Y-
dc.contributor.authorWong, CN-
dc.contributor.authorChandra, A-
dc.contributor.authorTang, ATS-
dc.contributor.authorChow, LKY-
dc.contributor.authorWun, WL-
dc.contributor.authorLevitskaya, Z-
dc.contributor.authorZhang, J-
dc.date.accessioned2017-11-21T03:03:55Z-
dc.date.available2017-11-21T03:03:55Z-
dc.date.issued2018-
dc.identifier.citationNucleic Acids Research, 2018, v. 46 n. D1, p. D918-D924-
dc.identifier.issn0305-1048-
dc.identifier.urihttp://hdl.handle.net/10722/249561-
dc.description.abstractIdentification of Master Regulators (MRs) during cancer development contributes greatly to the design of novel targeted therapy. However, it is challenging to trace the MR that regulate the gene signature (e.g. differentially expressed genes) derived from a limited number of transcriptome profiles. The main reason is that the targets (collectively termed as regulon) of MRs in cancer type-specific context is not available for enrichment analysis in the signature. To this aim, we generated the regulon of MRs using high throughput omics data from The Cancer Genome Atlas (TCGA), and developed a web server MR4Cancer, which can prioritize MRs driving phenotypic differentiation of interest in 26 cancer types. Based on the input gene list or expression profiles, it outputs six groups of ranked MRs, including transcription regulators, miRNAs, recurrently mutated genes, kinases, phosphatases, and hubs from protein-protein interaction network. Simultaneously, Gene Ontology and canonical pathway analyses are also conducted to further elucidate the function of MR candidates. Moreover, our tool presents dynamic network visualization for MR-target relations, and users can interactively customize it as high quality figures for their publications. We expect this user-friendly and powerful web application will provide researchers new insights into carcinogenesis and therapeutic intervention.-
dc.languageeng-
dc.publisherOxford University Press (OUP): Policy C - Option B. The Journal's web site is located at http://nar.oxfordjournals.org/-
dc.relation.ispartofNucleic Acids Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleCR2Cancer: a database for chromatin regulators in human cancer-
dc.typeArticle-
dc.identifier.emailZhang, J: jzhang1@hku.hk-
dc.identifier.authorityZhang, J=rp01713-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1093/nar/gkx877-
dc.identifier.hkuros282997-
dc.identifier.volume46-
dc.identifier.issueD1-
dc.identifier.spageD918-
dc.identifier.epageD924-
dc.identifier.isiWOS:000419550700134-
dc.publisher.placeUnited Kingdom-

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