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Article: Autism-like behaviours and memory deficits accompany a high cholesterol diet in mice

TitleAutism-like behaviours and memory deficits accompany a high cholesterol diet in mice
Authors
Issue Date2017
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/
Citation
Neural Plasticity, 2017, v. 2017, p. 9498247 How to Cite?
AbstractNonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing 0.2% of cholesterol and 21% of saturated fat for three weeks. WD-treated mice exhibited increased social avoidance, crawl-over and digging behaviours, decreased body-body contacts, and hyperlocomotion. The WD-fed group also displayed deficits in hippocampal-dependent performance such as contextual memory in a fear conditioning and pellet displacement paradigms. A reduction in glucose tolerance and elevated levels of serum cholesterol and leptin were also associated with the WD. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1a) mRNA, a marker of mitochondrial activity, was decreased in the prefrontal cortex, hippocampus, hypothalamus, and dorsal raphe, suggesting suppressed brain mitochondrial functions, but not in the liver. This is the first report to show that a WD can profoundly suppress social interactions and induce dominant-like behaviours in naïve adult mice. The spectrum of behaviours that were found to be induced are reminiscent of symptoms associated with autism, and, if paralleled in humans, suggest that a WD might exacerbate autism spectrum disorder.
Persistent Identifierhttp://hdl.handle.net/10722/249230
ISSN
2015 Impact Factor: 3.568
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorVeniaminova, E-
dc.contributor.authorCespuglio, R-
dc.contributor.authorCheung, CW-
dc.contributor.authorUmriukhin, A-
dc.contributor.authorMarkova, N-
dc.contributor.authorShevtsova, E-
dc.contributor.authorLesch, KP-
dc.contributor.authorAnthony, DC-
dc.contributor.authorStrekalova, T-
dc.date.accessioned2017-11-02T09:13:59Z-
dc.date.available2017-11-02T09:13:59Z-
dc.date.issued2017-
dc.identifier.citationNeural Plasticity, 2017, v. 2017, p. 9498247-
dc.identifier.issn2090-5904-
dc.identifier.urihttp://hdl.handle.net/10722/249230-
dc.description.abstractNonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing 0.2% of cholesterol and 21% of saturated fat for three weeks. WD-treated mice exhibited increased social avoidance, crawl-over and digging behaviours, decreased body-body contacts, and hyperlocomotion. The WD-fed group also displayed deficits in hippocampal-dependent performance such as contextual memory in a fear conditioning and pellet displacement paradigms. A reduction in glucose tolerance and elevated levels of serum cholesterol and leptin were also associated with the WD. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1a) mRNA, a marker of mitochondrial activity, was decreased in the prefrontal cortex, hippocampus, hypothalamus, and dorsal raphe, suggesting suppressed brain mitochondrial functions, but not in the liver. This is the first report to show that a WD can profoundly suppress social interactions and induce dominant-like behaviours in naïve adult mice. The spectrum of behaviours that were found to be induced are reminiscent of symptoms associated with autism, and, if paralleled in humans, suggest that a WD might exacerbate autism spectrum disorder.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/-
dc.relation.ispartofNeural Plasticity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAutism-like behaviours and memory deficits accompany a high cholesterol diet in mice-
dc.typeArticle-
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.identifier.authorityCheung, CW=rp00244-
dc.description.naturelink_to_OA_fulltext-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2017/9498247-
dc.identifier.pmid28685102-
dc.identifier.pmcidPMC5480052-
dc.identifier.hkuros282777-
dc.identifier.volume2017-
dc.identifier.spage9498247-
dc.identifier.epage9498247-
dc.publisher.placeUnited States-

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