File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/jop.12625
- Scopus: eid_2-s2.0-85028853624
- WOS: WOS:000414366000006
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Profiling cancer risk in oral potentially malignant disorders-A patient cohort study
Title | Profiling cancer risk in oral potentially malignant disorders-A patient cohort study |
---|---|
Authors | |
Keywords | Potentially malignant disorders Malignant transformation |
Issue Date | 2017 |
Citation | Journal of Oral Pathology & Medicine, 2017, v. 46 n. 10, p. 888-895 How to Cite? |
Abstract | © 2017 John Wiley & Sons A/S. Background: Oral potentially malignant disorders harbour variable and unpredictable risk for squamous carcinoma development. Whilst current management strategies utilise histopathological diagnoses, dysplasia grading and targeted intervention for "high-risk" lesions, clinicians are unable to predict malignant potential. Methods: Detailed, retrospective clinico-pathological analysis of potentially malignant lesions undergoing malignant transformation, from a 590 patient cohort treated by interventional laser surgery and followed for a mean of 7.3 years, was undertaken. Clinical outcome was documented at study census date (31 December 2014). Results: A total of 99 patients (16.8%) developed cancer: 71 (12%) seen "unexpectedly" upon excision and 28 (4.8%) progressing to malignancy at a median of 87.3 months post-surgery. Thirty "unexpected" excisions were micro-invasive (42.3%) arising primarily in severely dysplastic precursors (75%) at ventro-lateral tongue and floor of mouth sites (54.5%); 1 patient (1.4%) had a cancer-related death, whilst 58 (81.7%) were disease free. A total of 19 of 28 "progressive" cancers (67.9%) arose at new sites, with erythroleukoplakia a significant predictor of malignancy (P = .0019). Nine (32.1%) developed at the same precursor site, with 6 (77.7%) on the ventro-lateral tongue and floor of mouth. Three (10.7%) were micro-invasive, 9 patients (32.1%) died from metastatic disease and 12 (42.9%) were disease free (P < .001). Conclusion: Squamous carcinoma may arise at the site of a precursor lesion as transformation or new-site development via field cancerisation. Whilst interventional surgery facilitates early diagnosis and treatment of occult disease, thus reducing risk from same-site transformation, new-site cancer is a significant long-term risk for patients with potentially malignant disorder. |
Persistent Identifier | http://hdl.handle.net/10722/249169 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.716 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Thomson, P. J. | - |
dc.contributor.author | Goodson, M. L. | - |
dc.contributor.author | Smith, D. R. | - |
dc.date.accessioned | 2017-10-27T05:59:17Z | - |
dc.date.available | 2017-10-27T05:59:17Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Journal of Oral Pathology & Medicine, 2017, v. 46 n. 10, p. 888-895 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249169 | - |
dc.description.abstract | © 2017 John Wiley & Sons A/S. Background: Oral potentially malignant disorders harbour variable and unpredictable risk for squamous carcinoma development. Whilst current management strategies utilise histopathological diagnoses, dysplasia grading and targeted intervention for "high-risk" lesions, clinicians are unable to predict malignant potential. Methods: Detailed, retrospective clinico-pathological analysis of potentially malignant lesions undergoing malignant transformation, from a 590 patient cohort treated by interventional laser surgery and followed for a mean of 7.3 years, was undertaken. Clinical outcome was documented at study census date (31 December 2014). Results: A total of 99 patients (16.8%) developed cancer: 71 (12%) seen "unexpectedly" upon excision and 28 (4.8%) progressing to malignancy at a median of 87.3 months post-surgery. Thirty "unexpected" excisions were micro-invasive (42.3%) arising primarily in severely dysplastic precursors (75%) at ventro-lateral tongue and floor of mouth sites (54.5%); 1 patient (1.4%) had a cancer-related death, whilst 58 (81.7%) were disease free. A total of 19 of 28 "progressive" cancers (67.9%) arose at new sites, with erythroleukoplakia a significant predictor of malignancy (P = .0019). Nine (32.1%) developed at the same precursor site, with 6 (77.7%) on the ventro-lateral tongue and floor of mouth. Three (10.7%) were micro-invasive, 9 patients (32.1%) died from metastatic disease and 12 (42.9%) were disease free (P < .001). Conclusion: Squamous carcinoma may arise at the site of a precursor lesion as transformation or new-site development via field cancerisation. Whilst interventional surgery facilitates early diagnosis and treatment of occult disease, thus reducing risk from same-site transformation, new-site cancer is a significant long-term risk for patients with potentially malignant disorder. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Oral Pathology & Medicine | - |
dc.rights | This is the accepted version of the following article: Journal of Oral Pathology & Medicine, 2017, v. 46 n. 10, p. 888-895, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1111/jop.12625 | - |
dc.subject | Potentially malignant disorders | - |
dc.subject | Malignant transformation | - |
dc.title | Profiling cancer risk in oral potentially malignant disorders-A patient cohort study | - |
dc.type | Article | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1111/jop.12625 | - |
dc.identifier.scopus | eid_2-s2.0-85028853624 | - |
dc.identifier.hkuros | 283307 | - |
dc.identifier.volume | 46 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 888 | - |
dc.identifier.epage | 895 | - |
dc.identifier.eissn | 1600-0714 | - |
dc.identifier.isi | WOS:000414366000006 | - |
dc.identifier.issnl | 0904-2512 | - |