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Article: PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells

TitlePSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells
Authors
Keywordsnon-small-cell lung cancer
patient-derived xenograft
PSCA
MUC1
CAR T
Issue Date2017
Citation
OncoImmunology, 2017, v. 6, n. 3 How to Cite?
Abstract© 2017 Taylor & Francis Group, LLC. In recent years, immunotherapies, such as those involving chimeric antigen receptor (CAR) T cells, have become increasingly promising approaches to non-small-cell lung cancer (NSCLC) treatment. In this study, we explored the antitumor potential of prostate stem cell antigen (PSCA)-redirected CAR T and mucin 1 (MUC1)-redirected CAR T cells in tumor models of NSCLC. First, we generated patient-derived xenograft (PDX) mouse models of human NSCLC that maintained the antigenic profiles of primary tumors. Next, we demonstrated the expression of PSCA and MUC1 in NSCLC, followed by the generation and confirmation of the specificity and efficacy of PSCA- and MUC1-targeting CAR T cells against NSCLC cell lines in vitro. Finally, we demonstrated that PSCA-targeting CAR T cells could efficiently suppress NSCLC tumor growth in PDX mice and synergistically eliminate PSCA + MUC1 + tumors when combined with MUC1-targeting CAR T cells. Taken together, our studies demonstrate that PSCA and MUC1 are both promising CAR T cell targets in NSCLC and that the combinatorial targeting of these antigens could further enhance the antitumor efficacy of CAR T cells.
Persistent Identifierhttp://hdl.handle.net/10722/249158
ISSN
2014 Impact Factor: 6.266
2015 SCImago Journal Rankings: 1.485
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWei, Xinru-
dc.contributor.authorLai, Yunxin-
dc.contributor.authorLi, Jin-
dc.contributor.authorQin, Le-
dc.contributor.authorXu, Youdi-
dc.contributor.authorZhao, Ruocong-
dc.contributor.authorLi, Baiheng-
dc.contributor.authorLin, Simiao-
dc.contributor.authorWang, Suna-
dc.contributor.authorWu, Qiting-
dc.contributor.authorLiang, Qiubin-
dc.contributor.authorPeng, Muyun-
dc.contributor.authorYu, Fenglei-
dc.contributor.authorLi, Yangqiu-
dc.contributor.authorZhang, Xuchao-
dc.contributor.authorWu, Yilong-
dc.contributor.authorLiu, Pentao-
dc.contributor.authorPei, Duanqing-
dc.contributor.authorYao, Yao-
dc.contributor.authorLi, Peng-
dc.date.accessioned2017-10-27T05:59:15Z-
dc.date.available2017-10-27T05:59:15Z-
dc.date.issued2017-
dc.identifier.citationOncoImmunology, 2017, v. 6, n. 3-
dc.identifier.issn2162-4011-
dc.identifier.urihttp://hdl.handle.net/10722/249158-
dc.description.abstract© 2017 Taylor & Francis Group, LLC. In recent years, immunotherapies, such as those involving chimeric antigen receptor (CAR) T cells, have become increasingly promising approaches to non-small-cell lung cancer (NSCLC) treatment. In this study, we explored the antitumor potential of prostate stem cell antigen (PSCA)-redirected CAR T and mucin 1 (MUC1)-redirected CAR T cells in tumor models of NSCLC. First, we generated patient-derived xenograft (PDX) mouse models of human NSCLC that maintained the antigenic profiles of primary tumors. Next, we demonstrated the expression of PSCA and MUC1 in NSCLC, followed by the generation and confirmation of the specificity and efficacy of PSCA- and MUC1-targeting CAR T cells against NSCLC cell lines in vitro. Finally, we demonstrated that PSCA-targeting CAR T cells could efficiently suppress NSCLC tumor growth in PDX mice and synergistically eliminate PSCA + MUC1 + tumors when combined with MUC1-targeting CAR T cells. Taken together, our studies demonstrate that PSCA and MUC1 are both promising CAR T cell targets in NSCLC and that the combinatorial targeting of these antigens could further enhance the antitumor efficacy of CAR T cells.-
dc.languageeng-
dc.relation.ispartofOncoImmunology-
dc.subjectnon-small-cell lung cancer-
dc.subjectpatient-derived xenograft-
dc.subjectPSCA-
dc.subjectMUC1-
dc.subjectCAR T-
dc.titlePSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1080/2162402X.2017.1284722-
dc.identifier.scopuseid_2-s2.0-85015249378-
dc.identifier.volume6-
dc.identifier.issue3-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn2162-402X-
dc.identifier.isiWOS:000397988500019-

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