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Article: Mapping dynamic epithelial cell proliferative activity within the oral cavity of man: A new insight into carcinogenesis?

TitleMapping dynamic epithelial cell proliferative activity within the oral cavity of man: A new insight into carcinogenesis?
Authors
Issue Date1999
Citation
British Journal of Oral and Maxillofacial Surgery, 1999, v. 37, n. 5, p. 377-383 How to Cite?
AbstractOur aim was to characterize epithelial cell proliferative activity within the oral cavity and to find out if there were differences between sites with high and low incidence of cancer. A total of 105 samples of clinically normal mucosa were harvested from various intra-oral sites. Excised specimens were incubated in vitro with tritiated thymidine and bromodeoxyuridine to 'double label' cells undergoing DNA synthesis, and enable calculation of the duration of S phase and estimation of variables of cell flux to and from S. Mean labelling indices (percentage of cells within the S phase of the cell cycle) were highest in the floor of mouth (12.3%) and ventral tongue (10.1%), while activity was lowest in the dorsum of tongue (4.3%) and the palate (7.2%), P < 0.001). In general, both cell influx and the duration of S increased proportionally to the labelling index. Sites with a high incidence of cancer were characterized by high labelling indices, increased cell influx and a prolonged S phase.
Persistent Identifierhttp://hdl.handle.net/10722/249142
ISSN
2015 Impact Factor: 1.237
2015 SCImago Journal Rankings: 0.887

 

DC FieldValueLanguage
dc.contributor.authorThomson, P. J.-
dc.contributor.authorPotten, C. S.-
dc.contributor.authorAppleton, D. R.-
dc.date.accessioned2017-10-27T05:59:13Z-
dc.date.available2017-10-27T05:59:13Z-
dc.date.issued1999-
dc.identifier.citationBritish Journal of Oral and Maxillofacial Surgery, 1999, v. 37, n. 5, p. 377-383-
dc.identifier.issn0266-4356-
dc.identifier.urihttp://hdl.handle.net/10722/249142-
dc.description.abstractOur aim was to characterize epithelial cell proliferative activity within the oral cavity and to find out if there were differences between sites with high and low incidence of cancer. A total of 105 samples of clinically normal mucosa were harvested from various intra-oral sites. Excised specimens were incubated in vitro with tritiated thymidine and bromodeoxyuridine to 'double label' cells undergoing DNA synthesis, and enable calculation of the duration of S phase and estimation of variables of cell flux to and from S. Mean labelling indices (percentage of cells within the S phase of the cell cycle) were highest in the floor of mouth (12.3%) and ventral tongue (10.1%), while activity was lowest in the dorsum of tongue (4.3%) and the palate (7.2%), P < 0.001). In general, both cell influx and the duration of S increased proportionally to the labelling index. Sites with a high incidence of cancer were characterized by high labelling indices, increased cell influx and a prolonged S phase.-
dc.languageeng-
dc.relation.ispartofBritish Journal of Oral and Maxillofacial Surgery-
dc.titleMapping dynamic epithelial cell proliferative activity within the oral cavity of man: A new insight into carcinogenesis?-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1054/bjom.1999.0130-
dc.identifier.pmid10577752-
dc.identifier.scopuseid_2-s2.0-0032709289-
dc.identifier.volume37-
dc.identifier.issue5-
dc.identifier.spage377-
dc.identifier.epage383-

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