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Article: Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11
Title | Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11 |
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Authors | |
Issue Date | 1998 |
Citation | Genetics, 1998, v. 150, n. 3, p. 1155-1168 How to Cite? |
Abstract | Chromosome engineering in mice enables the construction of models of human chromosomal diseases and provides key reagents for genetic studies. To begin to define functional information for a small portion of chromosome 11, deficiencies, duplications, and inversions were constructed in embryonic stem cells with sizes ranging from 1 Mb to 22 cM. Two deficiencies and three duplications were established in the mouse germline. Mice with a 1-Mb duplication developed corneal hyperplasia and thymic tumors, while two different 3- to 4-cM deficiencies were embryonically lethal in heterozygous mice. A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality. |
Persistent Identifier | http://hdl.handle.net/10722/249140 |
ISSN | 2021 Impact Factor: 4.402 2020 SCImago Journal Rankings: 2.792 |
DC Field | Value | Language |
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dc.contributor.author | Liu, Pentao | - |
dc.contributor.author | Zhang, Heju | - |
dc.contributor.author | McLellan, Andrew | - |
dc.contributor.author | Vogel, Hannes | - |
dc.contributor.author | Bradley, Allan | - |
dc.date.accessioned | 2017-10-27T05:59:12Z | - |
dc.date.available | 2017-10-27T05:59:12Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Genetics, 1998, v. 150, n. 3, p. 1155-1168 | - |
dc.identifier.issn | 0016-6731 | - |
dc.identifier.uri | http://hdl.handle.net/10722/249140 | - |
dc.description.abstract | Chromosome engineering in mice enables the construction of models of human chromosomal diseases and provides key reagents for genetic studies. To begin to define functional information for a small portion of chromosome 11, deficiencies, duplications, and inversions were constructed in embryonic stem cells with sizes ranging from 1 Mb to 22 cM. Two deficiencies and three duplications were established in the mouse germline. Mice with a 1-Mb duplication developed corneal hyperplasia and thymic tumors, while two different 3- to 4-cM deficiencies were embryonically lethal in heterozygous mice. A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality. | - |
dc.language | eng | - |
dc.relation.ispartof | Genetics | - |
dc.title | Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11 | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 9799267 | - |
dc.identifier.scopus | eid_2-s2.0-0031770040 | - |
dc.identifier.volume | 150 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1155 | - |
dc.identifier.epage | 1168 | - |
dc.identifier.issnl | 0016-6731 | - |