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Article: Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity

TitleCritical roles of Bcl11b in T-cell development and maintenance of T-cell identity
Authors
KeywordsImmunotherapy
Identity
Transcription factor
Bcl11b
Natural killer
Reprogramming
T cells
Issue Date2010
Citation
Immunological Reviews, 2010, v. 238, n. 1, p. 138-149 How to Cite?
AbstractT-cell development primarily occurs in the thymus and involves in the interactions of many important transcription factors. Until recently, no single transcription factor has been identified to be essential for T-cell lineage commitment or maintenance of T-cell identity. Recent studies have now identified the zinc finger transcription factor Bcl11b to be essential for T-cell development and for maintenance of T-cell identity. Remarkably, T cells acquire NK cell properties upon Bcl11b deletion. These reprogrammed cells have unique properties in proliferation, cytokine dependency and killing target cells, and may therefore provide a new cell source for some cell-based therapies. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/249043
ISSN
2017 Impact Factor: 9.217
2015 SCImago Journal Rankings: 7.059
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Pentao-
dc.contributor.authorLi, Peng-
dc.contributor.authorBurke, Shannon-
dc.date.accessioned2017-10-27T05:58:57Z-
dc.date.available2017-10-27T05:58:57Z-
dc.date.issued2010-
dc.identifier.citationImmunological Reviews, 2010, v. 238, n. 1, p. 138-149-
dc.identifier.issn0105-2896-
dc.identifier.urihttp://hdl.handle.net/10722/249043-
dc.description.abstractT-cell development primarily occurs in the thymus and involves in the interactions of many important transcription factors. Until recently, no single transcription factor has been identified to be essential for T-cell lineage commitment or maintenance of T-cell identity. Recent studies have now identified the zinc finger transcription factor Bcl11b to be essential for T-cell development and for maintenance of T-cell identity. Remarkably, T cells acquire NK cell properties upon Bcl11b deletion. These reprogrammed cells have unique properties in proliferation, cytokine dependency and killing target cells, and may therefore provide a new cell source for some cell-based therapies. © 2010 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofImmunological Reviews-
dc.subjectImmunotherapy-
dc.subjectIdentity-
dc.subjectTranscription factor-
dc.subjectBcl11b-
dc.subjectNatural killer-
dc.subjectReprogramming-
dc.subjectT cells-
dc.titleCritical roles of Bcl11b in T-cell development and maintenance of T-cell identity-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-065X.2010.00953.x-
dc.identifier.pmid20969590-
dc.identifier.scopuseid_2-s2.0-77958553288-
dc.identifier.volume238-
dc.identifier.issue1-
dc.identifier.spage138-
dc.identifier.epage149-
dc.identifier.eissn1600-065X-
dc.identifier.isiWOS:000283509100011-

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