File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Using mouse models to study function of transcriptional factors in T cell development

TitleUsing mouse models to study function of transcriptional factors in T cell development
Authors
KeywordsLymphopoiesis
T cell development
Humanized mice
Genetic modified mice
Bcl11b
Issue Date2012
Citation
Cell Regeneration, 2012, v. 1 How to Cite?
AbstractLaboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we now understand hematopoiesis is a dynamic stepwise process starting from hematopoietic stem cells (HSCs) which are responsible for replenishing all blood cells. Transcriptional factors play important role in hematopoiesis. In this review we compile several studies on using genetic modified mice and humanized mice to study function of transcriptional factors in lymphopoiesis, including T lymphocyte and Natural killer (NK) cell development. Finally, we focused on the key transcriptional factor Bcl11b and its function in regulating T cell specification and commitment. © 2012 Li et al.; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/248986

 

DC FieldValueLanguage
dc.contributor.authorLi, Peng-
dc.contributor.authorXiao, Yiren-
dc.contributor.authorLiu, Zhixin-
dc.contributor.authorLiu, Pentao-
dc.date.accessioned2017-10-27T05:58:48Z-
dc.date.available2017-10-27T05:58:48Z-
dc.date.issued2012-
dc.identifier.citationCell Regeneration, 2012, v. 1-
dc.identifier.urihttp://hdl.handle.net/10722/248986-
dc.description.abstractLaboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we now understand hematopoiesis is a dynamic stepwise process starting from hematopoietic stem cells (HSCs) which are responsible for replenishing all blood cells. Transcriptional factors play important role in hematopoiesis. In this review we compile several studies on using genetic modified mice and humanized mice to study function of transcriptional factors in lymphopoiesis, including T lymphocyte and Natural killer (NK) cell development. Finally, we focused on the key transcriptional factor Bcl11b and its function in regulating T cell specification and commitment. © 2012 Li et al.; licensee BioMed Central Ltd.-
dc.languageeng-
dc.relation.ispartofCell Regeneration-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectLymphopoiesis-
dc.subjectT cell development-
dc.subjectHumanized mice-
dc.subjectGenetic modified mice-
dc.subjectBcl11b-
dc.titleUsing mouse models to study function of transcriptional factors in T cell development-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/2045-9769-1-8-
dc.identifier.scopuseid_2-s2.0-84988273211-
dc.identifier.volume1-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn2045-9769-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats