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- Publisher Website: 10.1186/2045-9769-1-8
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Article: Using mouse models to study function of transcriptional factors in T cell development
| Title | Using mouse models to study function of transcriptional factors in T cell development |
|---|---|
| Authors | |
| Keywords | Lymphopoiesis T cell development Humanized mice Genetic modified mice Bcl11b |
| Issue Date | 2012 |
| Citation | Cell Regeneration, 2012, v. 1 How to Cite? |
| Abstract | Laboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we now understand hematopoiesis is a dynamic stepwise process starting from hematopoietic stem cells (HSCs) which are responsible for replenishing all blood cells. Transcriptional factors play important role in hematopoiesis. In this review we compile several studies on using genetic modified mice and humanized mice to study function of transcriptional factors in lymphopoiesis, including T lymphocyte and Natural killer (NK) cell development. Finally, we focused on the key transcriptional factor Bcl11b and its function in regulating T cell specification and commitment. © 2012 Li et al.; licensee BioMed Central Ltd. |
| Persistent Identifier | http://hdl.handle.net/10722/248986 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Li, Peng | - |
| dc.contributor.author | Xiao, Yiren | - |
| dc.contributor.author | Liu, Zhixin | - |
| dc.contributor.author | Liu, Pentao | - |
| dc.date.accessioned | 2017-10-27T05:58:48Z | - |
| dc.date.available | 2017-10-27T05:58:48Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier.citation | Cell Regeneration, 2012, v. 1 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/248986 | - |
| dc.description.abstract | Laboratory mice have widely been used as tools for basic biological research and models for studying human diseases. With the advances of genetic engineering and conditional knockout (CKO) mice, we now understand hematopoiesis is a dynamic stepwise process starting from hematopoietic stem cells (HSCs) which are responsible for replenishing all blood cells. Transcriptional factors play important role in hematopoiesis. In this review we compile several studies on using genetic modified mice and humanized mice to study function of transcriptional factors in lymphopoiesis, including T lymphocyte and Natural killer (NK) cell development. Finally, we focused on the key transcriptional factor Bcl11b and its function in regulating T cell specification and commitment. © 2012 Li et al.; licensee BioMed Central Ltd. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Cell Regeneration | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | Lymphopoiesis | - |
| dc.subject | T cell development | - |
| dc.subject | Humanized mice | - |
| dc.subject | Genetic modified mice | - |
| dc.subject | Bcl11b | - |
| dc.title | Using mouse models to study function of transcriptional factors in T cell development | - |
| dc.type | Article | - |
| dc.description.nature | published_or_final_version | - |
| dc.identifier.doi | 10.1186/2045-9769-1-8 | - |
| dc.identifier.scopus | eid_2-s2.0-84988273211 | - |
| dc.identifier.volume | 1 | - |
| dc.identifier.spage | null | - |
| dc.identifier.epage | null | - |
| dc.identifier.eissn | 2045-9769 | - |
| dc.identifier.issnl | 2045-9769 | - |