File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Regulation of engineered nanomaterials: current challenges, insights and future directions

TitleRegulation of engineered nanomaterials: current challenges, insights and future directions
Authors
KeywordsAdverse outcome pathway
Alternatives risk assessment framework
Environmental fate and behaviour
Pre-market evaluation
Quantitative structure–activity relationship
Risk assessment framework
Issue Date2018
PublisherSpringer. The Journal's web site is located at http://www.springer.com/environment/journal/11356
Citation
Environmental Science and Pollution Research, 2018, v. 25 n. 4, p. 3060-3077 How to Cite?
AbstractSubstantial production and wide applications of engineered nanomaterials (ENMs) have raised concerns over their potential influences on the environment and humans. However, regulations of products containing ENMs are scarce, even in countries with the greatest volume of ENMs produced, such as the United States and China. After a comprehensive review of life cycles of ENMs, five major challenges to regulators posed by ENMs are proposed in this review: (a) ENMs exhibit variable physicochemical characteristics, which makes them difficult for regulators to establish regulatory definition; (b) Due to diverse sources and transport pathways for ENMs, it is difficult to monitor or predict their fates in the environment; (c) There is a lack of reliable techniques for quantifying exposures to ENMs; (d) Because of diverse intrinsic properties of ENMs and dynamic environmental conditions, it is difficult to predict bioavailability of ENMs on wildlife and the environment; and (e) There are knowledge gaps in toxicity and toxic mechanisms of ENMs from which to predict their hazards. These challenges are all related to issues in conventional assessments of risks that regulators rely on. To address the fast-growing nanotechnology market with limited resources, four ENMs (nanoparticles of Ag, TiO2, ZnO and Fe2O3) have been prioritized for research. Compulsory reporting schemes (registration and labelling) for commercial products containing ENMs should be adopted. Moreover, to accommodate their potential risks in time, an integrative use of quantitative structure-activity relationship and adverse outcome pathway (QSAR-AOP), together with qualitative alternatives to conventional risk assessment are proposed as tools for decision making of regulators. © 2017, Springer-Verlag GmbH Germany.
Persistent Identifierhttp://hdl.handle.net/10722/248518
ISSN
2017 Impact Factor: 2.8
2015 SCImago Journal Rankings: 0.886
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, WS-
dc.contributor.authorYeung, WYK-
dc.contributor.authorYung, MNM-
dc.contributor.authorDjurisic, A-
dc.contributor.authorGiesy, JP-
dc.contributor.authorLeung, KMY-
dc.date.accessioned2017-10-18T08:44:28Z-
dc.date.available2017-10-18T08:44:28Z-
dc.date.issued2018-
dc.identifier.citationEnvironmental Science and Pollution Research, 2018, v. 25 n. 4, p. 3060-3077-
dc.identifier.issn0944-1344-
dc.identifier.urihttp://hdl.handle.net/10722/248518-
dc.description.abstractSubstantial production and wide applications of engineered nanomaterials (ENMs) have raised concerns over their potential influences on the environment and humans. However, regulations of products containing ENMs are scarce, even in countries with the greatest volume of ENMs produced, such as the United States and China. After a comprehensive review of life cycles of ENMs, five major challenges to regulators posed by ENMs are proposed in this review: (a) ENMs exhibit variable physicochemical characteristics, which makes them difficult for regulators to establish regulatory definition; (b) Due to diverse sources and transport pathways for ENMs, it is difficult to monitor or predict their fates in the environment; (c) There is a lack of reliable techniques for quantifying exposures to ENMs; (d) Because of diverse intrinsic properties of ENMs and dynamic environmental conditions, it is difficult to predict bioavailability of ENMs on wildlife and the environment; and (e) There are knowledge gaps in toxicity and toxic mechanisms of ENMs from which to predict their hazards. These challenges are all related to issues in conventional assessments of risks that regulators rely on. To address the fast-growing nanotechnology market with limited resources, four ENMs (nanoparticles of Ag, TiO2, ZnO and Fe2O3) have been prioritized for research. Compulsory reporting schemes (registration and labelling) for commercial products containing ENMs should be adopted. Moreover, to accommodate their potential risks in time, an integrative use of quantitative structure-activity relationship and adverse outcome pathway (QSAR-AOP), together with qualitative alternatives to conventional risk assessment are proposed as tools for decision making of regulators. © 2017, Springer-Verlag GmbH Germany.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/environment/journal/11356-
dc.relation.ispartofEnvironmental Science and Pollution Research-
dc.subjectAdverse outcome pathway-
dc.subjectAlternatives risk assessment framework-
dc.subjectEnvironmental fate and behaviour-
dc.subjectPre-market evaluation-
dc.subjectQuantitative structure–activity relationship-
dc.subjectRisk assessment framework-
dc.titleRegulation of engineered nanomaterials: current challenges, insights and future directions-
dc.typeArticle-
dc.identifier.emailYung, MNM: manayung@connect.hku.hk-
dc.identifier.emailDjurisic, A: dalek@hku.hk-
dc.identifier.emailGiesy, JP: jgiesy@hku.hk-
dc.identifier.emailLeung, KMY: kmyleung@hku.hk-
dc.identifier.authorityDjurisic, A=rp00690-
dc.identifier.authorityLeung, KMY=rp00733-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11356-017-9489-0-
dc.identifier.scopuseid_2-s2.0-85021053043-
dc.identifier.hkuros280780-
dc.identifier.volume25-
dc.identifier.issue4-
dc.identifier.spage3060-
dc.identifier.epage3077-
dc.identifier.isiWOS:000425008900010-
dc.publisher.placeGermany-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats